1 Types of Gsubunits 2 Aim of the project To comparinga member of each family Chromosome 7 q21 Gs Chromosome 20 q132 Gproteinsin the Genome 3 CERINDIEG 12 1 MSVVLLPGGARERRAGSGARD ID: 184320
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1 G PROTEINS alpha subunitsHulya Cabadak Paula Garcia NogalesBarbara Guinea Types of Gsubunits 2 Aim of the project: To comparinga member of each family. Chromosome 7 q21 Gs Chromosome 20 q13.2 Gproteinsin the Genome 3 C----------------ERINDIEG 12 1 MSVVLLPGGARERRAGSGARDAEERSDARRRMGCKIQLKQVYLMGCT-------LSAED----------------AASKMIDRNDAG_q_ 37 LLLGTGESGKSFIGYSDEGF---------------FTMLLLGAGESGKSFLREEFIF---------------KGSLLLGAGESGKSIHFSNSDGEKATKVQDIKNNLKEAIG_i_ 37 LLLGAGESGKSIEAYSEEKQYKVT---------------QSIRAMDKYKAQLDVEFENP----YVDPGILVARDKLGQ--ENKFENEPATFQLYVALSVASNENQFYISVMNDFPF----YKALWDEGVAIRFDDRQLGAAE-MTAIKRLNADPAYLPTEDLIFSRFESVLDNQLPSKLKHDVIPFEYQLDCAQYFLDVIKQADYVPSDTSFQVDFFNRSYYLNPTFDLHFMVRSERRKWIIMFLESEKALFTIIG 12 224 KMRSRQFQCFGITSILFMVSSRRTNRVFETIVG_s_ 220 MFDNDVTSSYNMVIRQQENLFSIWG_i_ 197 KMRSERSDNRHSICG_q_ 256 PWFNSSVNKKDLLEEKDGPQEG 12 284 LFFNVSINKMDLLKFPDFGG_s_ 280 WVNKQDLLKSKIAPEDAG_i_ 257 KWFDTSINKKDFKKSLNTYA-------------G_q_ 302 ILLNPDSD---IYNLVYLVQCPAIIMQIPRRNDCDIIHLRQYELLILNENVQDVIINLKDCGF GTP binding site N-terminalbinding region)Receptor couplingsite C-terminalGXGXXGKSDXXGNKXD (Ras like domain) Hd (helical domain) subunit 4 Rd