PPT-Human Genetic Variation

Your Subtitle Goes Here Introduction Two objectives Major concepts related to human genetic variation Relationship between basic biomedical research and the improvement of personal and public health. HapMap. Peter Castaldi. January 29, 2013. Objectives. Introduce the concept of linkage disequilibrium (LD). Describe how the . HapMap. project provides publically available information on genetic variation and LD structure. Population structure . in case-control studies. Population consists of underlying subpopulations.. Disease prevalence different between subpopulations.. Cases preferentially ascertained from specific subpopulations.. Genetic Variation- the raw material for evolution. Evolution. A change in allele frequencies across generations. Evolution. A change in allele frequencies across generations. Selection. Genetic Drift. Ling Fung . Tang. 1,5. , . Michael L . Heuer. *2. , Nathan Salomonis. 3. , Alexander Pico. 4. , . Pui. Yan Kwok. 1,5,6. University . of California, San Francisco, Institute of Human Genetics, San Francisco, CA, . Gil . McVean. There are no new questions in population genetics. …only new types of data. Genome sequences of entire populations. Data with linkage to deep phenotype information. Data from multiple species. Image from about.com . meiosis_metaphase_1.jpg. . Mutations. (changes in an organism’s DNA) are the . original. . source of . all. genetic variation. Mutations create different versions of genes called . eyes, what . frequency of the population . is hybrid for brown eyes? Homozygous for brown eyes. ?. 2. . How . does sexual . reproduction . produce variation. ?. 3. Why are point/substitution mutations also known as silent mutations?. The Process of Speciation . How Common Is Genetic Variation?. Many genes have at least two forms alleles.. All organisms have genetic variation that is “invisible” because it involves small differences in biochemical processes.. Part 1. Learning Objectives. 1. Describe how variation within groups is maintained and how variation among groups is maintained.. 2. . Describe modern human biological diversity and articulate an informed position on the question of biological races of humans. . You can compare dogs of every breed imaginable! . There is an enormous range of characteristics that are the result of . genetic variation. . . The differences among breeds of dogs are so great that someone might think that many of these breeds are different species. . Behavior Genetics: . Predicting Individual Differences. The topics in the text:. genes. twin and adoption studies . temperament and heredity. molecular genetics. heritability. gene/environment interaction. BMI/CS 776 . www.biostat.wisc.edu/bmi776/. Spring . 2018. Anthony Gitter. gitter@biostat.wisc.edu. These slides, excluding third-party material, are licensed under . CC BY-NC 4.0. . by Mark Craven, Colin Dewey, and Anthony Gitter. Identify. three examples of inherited characteristics, and three environmental characteristics. Explain. why sound cannot be heard in space. Suggest. some advantages and disadvantages of recycling. Biology Trending, 4e. Eli Minkoff and Jennifer Hood-DeGrenier. There is biological variation both within and between human populations. Continuous and discontinuous variation within populations. Variation between populations.