PPT-Mendelian

Randomization Genes as Instrumental Variables David Evans University of Queensland This Session What is Mendelian Randomization MR Examples of MR in research Some ideas Using R to perform MR. Genetics. Law of Independent Assortment. What is inheritance?. Passing of genetic information from one generation to the next. Law of. Independent. . Assortment . not connected with another or with each other; separate.. Heredity. CH12 . pg. 267. Sexual Reproduction. Combining of a sperm cell and an egg cell from two individuals . The offspring of this "cross" will have characteristics from both "parents“. hybrid. Gabor T. Marth. Boston College Biology . Department. BI543 Fall 2013. February 5, . 2013. Medical variations. Phenotypic . effects . are often caused . by . genetic . variants. Many SNPs have phenotypic effects. 2015-2016. Ms. McCabe. standards. SC.912.L.16.1 Use Mendel’s laws of segregation and independent assortment to . analyze. patterns of . inheritance.. SC.912.L.16.2 . . Discuss. observed inheritance patterns caused by various modes of inheritance, including dominant, recessive, codominant, sex-linked, polygenic, and multiple alleles.. Review. ____________________ is the “Father of Genetics”.. Gregor. Mendel. _______________ is the passing of traits from parent to offspring.. Heredity. A _________ represents the physical characteristics.. With special thanks to. Kathrin Stanger-Hall. and. Jess Blum. University of North Carolina, Chapel Hill. Jean . DeSaix. Kelly Hogan. University of California, Santa Barbra. Rolf . Christoffersen. Stu Feinstein. EQ: How do we get certain traits?. Who is Gregor Mendel?. Considered to be the ‘father’ of genetics. Austrian monk born in 1822. Priest who studied science and mathematics at the University of Vienna. David Evans. Some Criticisms of GWA Studies…. So you have a new GWAS hit for a disease… so what!?. You can’t change people’s genotypes (at least not yet). You can however modify people’s environments…. The presence of mid-digital hair is a dominant condition; therefore those lacking it are homozygous recessive.. Middigital. Hair. Freckles. Freckles are small, concentrated spots of a skin pigment called melanin. Most fair-skinned, red-haired people have them.. Chapter 15, Section 5. Genomic Imprinting. For a few mammalian traits (2-3 dozen), the phenotype depends on which parent passed along the alleles for those traits.. Such variation in phenotype is called . David Evans. University of Queensland. University of Bristol. Some Criticisms of DOC Modelling in Twins. Measurement error. Power (both variables need to have radically different aetiologies). Only useful for testing strong hypotheses about causation. 1 Human Population Genetics Mendelian Inheritance in Man Paper No. : 0 8 Human Population Genetics Module : 0 6 Mendelian Inheritances in Man Prof. Anup Kumar K apoor multifactorial traits affected research into Mendelian disorders? Stylianos E. Antonarakis. For about a century, the argument for focusing on rare Mendelian disorders was as follows: Mendelian ph Exceptions. Mendel got lucky – all 7 traits he studied showed . complete . (simple). dominance. .. Mendelian. Exceptions. Mendel got lucky – all 7 traits he studied showed . complete . (simple).