PPT-Cytokines and Chemokines

Objectives General Properties of Cytokines and Chemokines Six Families of Cytokines Cytokine Antagonists CytokineRelated Diseases CytokineBased Therapies Dr Refif S Al Shawk Lec. David Jackson. Clinical Research . Fellow. Department of Respiratory Medicine. National Heart and Lung Institute. Imperial College London. Introduction. Asthma is a chronic condition characterised by reversible airflow obstruction, airway hyper-responsiveness, and airway inflammation. 22. Physiological mechanisms of regulation of the immune system. Cytokines (classification according to the function).. 23. Defence against extracellular pathogens .. 24. Defence against intracellular .. Cytokine Receptors. These are the receptors present on membrane of responsive . target cells by which cytokines binds to exert their biological effects.. Cytokine Receptors Fall Within Five Families. Response. A review. The 3 Lines of Defense. FIRST line: Barrier protection. non-specific (treats . each pathogen the . same). acts to prevent the pathogen from getting into the body. skin, mucous membranes, tears, sweat. . Abul K. . Abbas. UCSF. FOCiS. 2. Lecture outline. Cytokines . Subsets of CD4 T cells: definitions, functions, development . New therapeutic strategies targeting cytokines . 3. The life history of T lymphocytes. M.wt. . glycoproteins which are produced by cells of the innate and adaptive immune systems and, in particular by CD4. +. T cells, which orchestrate many effector mechanisms.. Cytokines serve as chemical messengers within the immune system.. Class name – VILS. Course name - LS-IMMUNOLOGY. (Rohit). Alternate Tick over pathway. We have discussed Fluid phase C3 convertase . Diagram depicts how fluid phase C3 convertase forms.. Membrane bound C3 convertase. Class name – VILS. Course name - ZOO-Biotech. (Rohit). How T-cells are activated. Two signals are required for T-cell activation namely Signal 1 and Signal 2. . Signal 1 . is provided by antigen-specific TCR . into Tissues. Chapter 3. CHEMOKINES AND CHEMOKINE RECEPTORS. Biologic Actions of Chemokines. Chemokines are essential for the . recruitment. of circulating leukocytes from blood vessels into extravascular. 1 secreted, low-molecular-weight proteins that regulate the nature, intensity and duration of the immune response by exerting a variety of effects on lymphocytes and/or other cells.-Cytokines bind to responsebiomaterialimmunerepresentingimportantNovelimmundomodulatorybiomater-ials:discoveringnovelbiomaterialsthatcanmitigatetheforeign-bodyresponseandenhanceengraftmentnewtrendthe http://dx.doi.org/1 Cytokines despite being nonspecific immunity it regulate the intensity and duration of the inflammatory/immune response.. Most cytokines are single polypeptide chains, may be aggregate as a homotrimer e.g. IL-12, IL-23. ®. Cytokines are rapidly secreted upon expression which results in. low / not detectable intracellular concentrations.. The use of secretion inhibitors allows for intracellular accumulation of cytokines:. Dr.V.Shanthi. Associate professor, Pathology. Sri Venkateswara Institute of Medical Sciences, Tirupathi. CHEMICAL MEDIATORS. Cell membrane phospholipids. Arachidonic acid. (20-carbon polyunsaturated fatty acid) .