PPT-Cytokines and Chemokines

Objectives General Properties of Cytokines and Chemokines Six Families of Cytokines Cytokine Antagonists CytokineRelated Diseases CytokineBased Therapies Dr Refif S Al Shawk Lec. Immunology Ontologies and Their Applications in Processing Clinical Data. June 11-13, Buffalo, NY. Confessions. I am an ontological newbie. Idea for a new ontology of immune networks. Immunologists I’ve talked to like the idea. presented by. Dr . Hadeel. F. Gad. Leishmania . and Mycobacterium TB share many similarities in their pathogenesis and both pathogens are macrophage parasites. . Furthermore, . co-infection by the two pathogens is not uncommon in clinical practice in East Africa and in other parts of the world (Sati 1942; el-Safi et al. 1995; Khalil et al. 1998, . Cytokine Receptors. These are the receptors present on membrane of responsive . target cells by which cytokines binds to exert their biological effects.. Cytokine Receptors Fall Within Five Families. Response. A review. The 3 Lines of Defense. FIRST line: Barrier protection. non-specific (treats . each pathogen the . same). acts to prevent the pathogen from getting into the body. skin, mucous membranes, tears, sweat. . Abul K. . Abbas. UCSF. FOCiS. 2. Lecture outline. Cytokines . Subsets of CD4 T cells: definitions, functions, development . New therapeutic strategies targeting cytokines . 3. The life history of T lymphocytes. M.wt. . glycoproteins which are produced by cells of the innate and adaptive immune systems and, in particular by CD4. +. T cells, which orchestrate many effector mechanisms.. Cytokines serve as chemical messengers within the immune system.. Effector. T Cells. Cell-mediated immunity (CMI) . is the type of host defense that is mediated by . T lymphocytes. , and it serves as a defense mechanism against . intracellular. and . phagocytosed. Class name – VILS. Course name - ZOO-Biotech. (Rohit). How T-cells are activated. Two signals are required for T-cell activation namely Signal 1 and Signal 2. . Signal 1 . is provided by antigen-specific TCR . into Tissues. Chapter 3. CHEMOKINES AND CHEMOKINE RECEPTORS. Biologic Actions of Chemokines. Chemokines are essential for the . recruitment. of circulating leukocytes from blood vessels into extravascular. Dr. Refif S. Al-. Shawk. . 2022. . Cancer. is altered self cells that have escaped normal growth regulating mechanisms.. These cells give rise to clones of cells that can expand to a considerable size, producing a tumor, or . 1 secreted, low-molecular-weight proteins that regulate the nature, intensity and duration of the immune response by exerting a variety of effects on lymphocytes and/or other cells.-Cytokines bind to Combat Major Infections Nonspecific and Specific Defense Systems - work together to coordinate their responses Nonspecific (Innate) Response - responds quickly, fights all invaders and consists of Cytokines despite being nonspecific immunity it regulate the intensity and duration of the inflammatory/immune response.. Most cytokines are single polypeptide chains, may be aggregate as a homotrimer e.g. IL-12, IL-23. ®. Cytokines are rapidly secreted upon expression which results in. low / not detectable intracellular concentrations.. The use of secretion inhibitors allows for intracellular accumulation of cytokines:.