PPT-1 Effector T Cell Subsets, Cytokines

Abul K Abbas UCSF FOCiS 2 Lecture outline Cytokines Subsets of CD4 T cells definitions functions development New therapeutic strategies targeting cytokines 3 The life history of T lymphocytes. 22. Physiological mechanisms of regulation of the immune system. Cytokines (classification according to the function).. 23. Defence against extracellular pathogens .. 24. Defence against intracellular .. Immunology Ontologies and Their Applications in Processing Clinical Data. June 11-13, Buffalo, NY. Confessions. I am an ontological newbie. Idea for a new ontology of immune networks. Immunologists I’ve talked to like the idea. Cytokine Receptors. These are the receptors present on membrane of responsive . target cells by which cytokines binds to exert their biological effects.. Cytokine Receptors Fall Within Five Families. Response. A review. The 3 Lines of Defense. FIRST line: Barrier protection. non-specific (treats . each pathogen the . same). acts to prevent the pathogen from getting into the body. skin, mucous membranes, tears, sweat. Brown Bag. February 16, 2010. Synopsis of Topics. Overview of CD4 . T cell subsets. Th17 cells and . Tregs. . Mechanisms of commitment to individual lineages (Th1, Th2, Th17). Relationships between . Murugan. , . M.Sc., . M.Phil.. , Ph.D.,. Assistant Professor and Principal . i/c. Department of Biochemistry,. Bharathidasan. University Model College,. Vedharanyam. - 614 810.. Antibody Mediated Effector Functions. M.wt. . glycoproteins which are produced by cells of the innate and adaptive immune systems and, in particular by CD4. +. T cells, which orchestrate many effector mechanisms.. Cytokines serve as chemical messengers within the immune system.. Effector. T Cells. Cell-mediated immunity (CMI) . is the type of host defense that is mediated by . T lymphocytes. , and it serves as a defense mechanism against . intracellular. and . phagocytosed. Class name – VILS. Course name - LS-IMMUNOLOGY. (Rohit). Alternate Tick over pathway. We have discussed Fluid phase C3 convertase . Diagram depicts how fluid phase C3 convertase forms.. Membrane bound C3 convertase. Class name – VILS. Course name - ZOO-Biotech. (Rohit). How T-cells are activated. Two signals are required for T-cell activation namely Signal 1 and Signal 2. . Signal 1 . is provided by antigen-specific TCR . A review. The 3 Lines of Defense. FIRST line: Barrier protection. non-specific (treats . each pathogen the . same). acts to prevent the pathogen from getting into the body. skin, mucous membranes, tears, sweat. Objectives. General Properties of Cytokines and Chemokines. Six Families of Cytokines . Cytokine Antagonists . Cytokine-Related Diseases . Cytokine-Based Therapies. Dr. Refif S. Al-. Shawk. . Lec. Cytokines despite being nonspecific immunity it regulate the intensity and duration of the inflammatory/immune response.. Most cytokines are single polypeptide chains, may be aggregate as a homotrimer e.g. IL-12, IL-23. +. CD8. +. T cells with Antiviral or Antibody Suppressor Functions. Sydney L Castellanos, Jason M Zimmerer, Ravi Dhital, Masako Shimamura, and Ginny L Bumgardner. ABSTRACT. HYPOTHESIS. RESULTS. CONCLUSION.