PPT-Elbasvir

Author : pamella-moone | Published Date : 2017-06-22

Grazoprevir in GT 1 and Chronic Renal Disease C SURFER Phase 3 Treatment Naïve and Treatment Experienced Roth D et al Lancet 2015386153745 Source Roth D

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Elbasvir: Transcript

Grazoprevir in GT 1 and Chronic Renal Disease C SURFER Phase 3 Treatment Naïve and Treatment Experienced Roth D et al Lancet 2015386153745 Source Roth D et al Lancet 2015386153745. Design. C-SCAPE . Study. : . grazoprevir. ± . elbasvir. ± RBV . in . genotypes. 2, 4, 5 or 6. Treatment-naïve . Genotype 2. , 4, 5, 6. Non-cirrhotic, . HCV . monoinfected. Brown . A. . . J . Hepatol. C-WORTHY Study Part C: . grazoprevir. . + . elbasvir. ± RBV in genotype 1b. GZR + EBR + RBV. N = 30. N = 31. Design. W8. C-WORTHY/C. Vierling. . JM. EASL 2015, . Abs. . P0769 . >. 18 years. HCV genotype 1b. Design. C-SCAPE . Study. : . grazoprevir. ± . elbasvir. ± RBV . in . genotypes. 2, 4, 5 or 6. Treatment-naïve . Genotype 2. , 4, 5, 6. Non-cirrhotic, . HCV . monoinfected. Brown . A. . . J . Hepatol. . +/- Ribavirin in HCV Genotype 1, 4 or 6. C-EDGE Treatment Experienced (TE). Phase 3. . Treatment. . Experienced. Kwo. P, . et al. . EASL 2015. Abstract P0886.. Source: . Kwo. P et al. EASL 2015. Abstract P0886.. + . Grazoprevir. +/- Ribavirin in . Treatment-Naïve HCV . GT 2, 4, 5, or 6. C-SCAPE. Phase . 2 . Treatment. . Naïve. Brown A, . et al. . EASL 2015; Abstract P0771.. Source: Brown A, et al. EASL 2015; Abstract P0771.. . + . Sofosbuvir. . in Treatment-Naïve HCV Genotype . 1 or 3. C-SWIFT. Phase . 2 . Treatment. . Naïve. Poordad. . F, . et al. . EASL 2015; Abstract O006.. Source: . Poordad. F, et al. EASL . 2015; Abstract . in genotypes 1 or 3, with or without cirrhosis. >. 18 years. Chronic HCV infection. Genotype 1 or 3. HCV RNA > 10 000 IU. /ml. Treatment-naïve . Cirrhosis assessed by liver biopsy or noninvasive tests. Randomisation*. Open-label. >. 18 years. HCV genotype 1. HCV RNA ≥ 10,000 IU. /ml. Treatment naïve and . compensated cirrhosis (Child-Pugh A). or. Null responders to previous PEG-IFN + RBV, with or without cirrhosis. in genotypes 1 or 3, with or without cirrhosis. >. 18 years. Chronic HCV infection. Genotype 1 or 3. HCV RNA > 10 000 IU. /ml. Treatment-naïve . Cirrhosis assessed by liver biopsy or noninvasive tests. Ribavirin in PI-experienced HCV GT1. C-SALVAGE. Phase . 2 . Treatment. . Experienced. (1) . Buti. M, et al. . Clin. Infect Dis. 2016;62:32-6. (2) . Forns. X, et al. J . Hepatol. . 2015;63:564-72. C-EDGE Treatment Naïve (TN). Phase 3. . Treatment. . Naïve. Zeuzem. S, . et al. . Ann Intern Med. 2015;163:1-13.. Source: . Zeuzem. S, et al. Ann Intern Med. 2015;163:1-13. .. Elbasvir-Grazoprevir. Medical Director, Austin Hepatitis Center. 1. Hepatitis C & PCP’s. 2. LACK OF AWARENESS. LACK OF APPROPRIATE ACTION. Expand Quantitative Landscape Study – Oct 2013 [Gilead Sciences]. 35-50% of PCP believe HCV can be cured. C-WORTHY/D. GZR + EBR + RBV. GZR + EBR + RBV. N = 21. N = 20. Design. W12. W18. SVR. 12. >. 18 years. HCV genotype . 3. HCV RNA ≥ 10 000 IU/mL. Treatment naïve . No cirrhosis. No HBV or HIV co-infection. HCV . GT 1,4, or 6 in PWID* on Opiate Agonist Therapy. C-EDGE CO-STAR. Phase . 2. Treatment. . Naïve. Dore G, . et al. . AALSD. 2015; Abstract 40. . Injection Drug Use. *PWID = Persons . W. ho . I.

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