PPT-Thyroid dose estimation for epidemiologic studies

André Bouville NCI retired and Vladimir Drozdovitch NCI Workshop on Radiation and Thyroid Cancer Tokyo Japan 22 February 2014 1 Outline Background information Principles of dose reconstruction. 1. Critically reading . epidemiologic studies. Principles of Epidemiology for Public Health (EPID600). Victor J. Schoenbach,. . PhD . home page. Department of Epidemiology. Gillings. School of Global Public Health. Roy Shore, . Kyoji. Furukawa, . Misa. . Imaizumi. Radiation Effects Research Foundation. shore@rerf.or.jp. Atomic Bomb Survivor Study Overview. 2. A-bomb Study Characteristics. Life Span Study. Includes >86,000 survivors of all ages at exposure, with estimated doses and long follow-up for mortality (1950-2008) and cancer incidence (1958-2009). radioiodine(I-131) . intake for evacuees caused by the nuclear accident in Fukushima. S. . Tokonami. , M. . Hosoda . (. Hirosaki. . Univ. .). S. . Akiba. . (Kagoshima . Univ. .). INTRODUCTION. After nuclear accident in Fukushima on March 11. INTRODUCTION. Thyroid rule:. In . a child, . critical for normal . growth and development. .. . In an adult, . maintain metabolic stability. . . Thyroid disorders result in . alterations in metabolic . V.K.. . Ivanov. Chairman, Russian Scientific Commission on Radiological Protection. . Medical Radiological Research Center . National Radiation and Epidemiological Registry. The International Workshop on . Introduction. . The prevalence of hypothyroidism . is. . higher. in . older. age groups and in whites and Hispanics; blacks had a lower prevalence of hypothyroidism. . The prevalence of hypothyroidism correlated with age. Compared with the total population, people aged 50 to 79 years had an almost twofold higher prevalence, and those aged 80 years and older had a fivefold higher prevalence. . Radiation Medical Science Center. . for the . Fukushima Health Management Survey,. Fukushima Medical University. The International Workshop on Radiation and Thyroid Cancer. Tetsuo Ishikawa. , Seiji . Thyroid rule:. In . a child, . critical for normal . growth and development. .. . In an adult, . maintain metabolic stability. . . Thyroid disorders result in . alterations in metabolic . stability. Shadi. . Haghi. M.D.. Research Institute for Endocrine Sciences. Shahid. . Beheshti. University of Medical sciences. 30 June 2014. AGENDA. A review on thyroid hormone treatment. (Endocrine 2013). to Causation. What is a Cause?. Merriam-Webster Dictionary. : Something that brings about a result especially a person or thing that is the agent of bringing something about.. KJ Rothman. : An event, condition, or characteristic without which the disease would not have occurred.. Director, Chernobyl Tissue Bank . (. www.chernobyltissuebank.com. ). gerry.thomas@imperial.ac.uk. HEALTH . EFFECTS OF . NUCLEAR . POWER . INCIDENTS – WHERE CHEMISTRY AND PHYSICS COMBINE TO DRIVE BIOLOGY. f. ollowing the Fukushima Daiichi . NPP . accident. International Workshop on Radiation and Thyroid Cancer. 22 February, Tokyo, JAPAN. Outline. WHO. 's mandate. First-year dose estimation (preliminary dose estimation report). Function Testing . Strategy. Clinical Details . Provided:. Tests Required:. Patient NOT on Thyroid . m. edication . OR. . Patient on T4. Patient . under . 18. OR. Patient . is pregnant . OR . Suspected/Known Pituitary disorder. Dr . Hiren. . Patt. D.M.. (Endocrinology). Myxoedema. Coma. What is . Myxoedema. Coma?. Severe hypothyroidism. Slowing of functions of multiple organs .