Differentiation and Functions of - PowerPoint Presentation

Slide1

Differentiation and Functions ofCD8+ Effector T CellsSlide2
Slide3

DIFFERENTIATION OF CD8+ T CELLS INTO CYTOTOXIC T LYMPHOCYTESSlide4

Induction and effector phases of CD8+

T cell

responsesSlide5

Nature of Antigen and Antigen-Presenting Cells for Activation of CD8+ T Lymphocytes

The activation of naive CD8+ T cells, like that of all naive

T cells

, is

best

initiated by antigens presented by

dendritic

cellsSlide6

Role of helper T cells in the differentiation of

CD8

+

T lymphocytesSlide7

Role of CytokinesIL-2 promotes

proliferation

and

differentiation

of CD8

+ T cells into CTLs and memory

cells

IL-12

and

type I IFNs

have both been shown to

stimulate the

differentiation

of naive CD8+ T cells into

effector CTLs

IL-15

is important for the

survival of memory

CD8+

and

may be produced by many cell types,

including

dendritic

cells

IL-21

produced by activated CD4+ T cells has

been shown

to play a role in the

induction

of CD8+ T

cell memory

and the

prevention

of CD8+ T cell

exhaustionSlide8

T cell exhaustionSlide9

EFFECTOR FUNCTIONS OF CD8+ CYTOTOXICT LYMPHOCYTESSlide10

Mechanisms of CTL-Mediated CytotoxicitySlide11

Recognition of Antigen and Activation of CTLsSlide12

Mechanisms of CTL-mediated killing of target cellsSlide13

ROLES OF CD8+ CTLs IN HOST DEFENSEIn infections by

intracellular microbes

, the killing

activity of

CTLs is important for eradication of the

reservoir of

infection

Destruction of infected cells by CTLs is a cause of

tissue injury

in some infectious

diseases

CTLs are important mediators of

tumor

immunity

and

the

rejection

of organ transplantsSlide14