Karen 2 amp Xingwei CLASS General Biology Class Size 4050 Freshmen Biology Majors Learning Goal Students will be able to evaluate the overall importance of the transport mechanism to normal cell functioning ID: 592619
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Slide1
Passing Through
Karen
2
& XingweiSlide2
CLASS: General Biology
Class Size: 40-50 Freshmen, Biology Majors
Learning Goal:
Students will be able to evaluate the overall importance of the transport mechanism to normal cell functioning
Learning Outcomes:
Students will be able to identify molecules that can diffuse across the
phospholipid bilayer
Students will be able to identify molecules that are transported across the membraneSlide3
BOND, JAMES BOND
http://www.youtube.com/watch?v=_yNntwSjOwo
Slide4
What did you observe?
What do you know about the situation?
What do you need to know?Slide5
In the US, 5 million people suffer from heart disease such as congestive heart failure and cardiac arrhythmias.
A cardiac glycoside such as Digitoxin
, also called Digitalis is used to treat this.
In Casino Royale, James Bond is given a dose of Digitalis, however, he almost dies?
WHAT’S GOING
ON?!!!!!!!!!!!!!!!!!!!!!
Previously…on “Passing Through”
- Fats, Fats and more FatsSlide6
Phospholipid
Bilayer in Cell Membrane
http://upload.wikimedia.org/wikipedia/commons/f/f0/Lipid_bilayer_section.gif
http://library.thinkquest.org/C004535/cell_membranes.htmlSlide7Slide8
Phospholipids form a lipid bilayer
that create a selectively permeable barrierSlide9
For each of the Chemical species show below. Identify whether they would be able to easily pass through the
lipid bilayer
or not. (3 minutes)
O
2
Oxygen
Sucrose
Fast
NO
Ions
Na
+
, Cl
-
K
+Slide10
Some chemical species can diffuse across a lipid bilayer
Others can not
O
2
Oxygen
Sucrose
Fast
NO
Ions
Na
+
, Cl
-
K
+
Non polar
Large polar or charged
hydrophilicSlide11
Cell membranes are not just made of phospholipids….
Do some molecules need proteins to cross the membrane?Slide12
Diffusion
Facilitated diffusion
Active transport
Passive Movement with the
Concentration gradient
No Proteins
involved
ADP
P
i
H
2
O
H
2
O
ATP
CO
2
CO
2
CO
2
O
2
O
2
CO
2
O
2
Outside
cell
Inside
cell
Against
Concentration gradient
Requires Transport ProteinsSlide13
Cellular Conditions
N
2
Lactose
Ca
+2
With ATP
+
+
+
No ATP
+
+
--
Protein Synthesis Inhibitor
+
--
--
Table 1.
Transport of molecules across a cell membrane.
Consider the following experiment on these
different chemical species
Think-Pair-Share: Which of the following enters the cell by active transport?
A = N
2
B=Lactose C= Ca
+2Slide14
http://pharmacologycorner.com/animation-showing-digoxin-mechanism-of-action-effects-at-molecular-tissue-and-system-levels/
SODIUM POTASSIUM PUMPSlide15Slide16
ACTION OF CONTRACTION IN THE HEARTSlide17Slide18
Na
+/K+-ATP-aseSlide19
Digitalis Attached to the Na
+/K+-ATP-
ase