The Duke Experience Gillian D Sanders PhD EPC Director Associate Professor of Medicine Duke Clinical Research Institute Duke University AHRQ Evidencebased Practice Centers EPCs BCBS Technology Evaluation Center TEC ID: 348460
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Assembling a Systematic Review Team:The Duke Experience
Gillian D Sanders PhD
EPC Director
Associate Professor of Medicine
Duke Clinical Research Institute
Duke UniversitySlide2
AHRQ Evidence-based Practice Centers (EPCs)
BCBS Technology Evaluation Center (TEC)
Naomi Aronson, PhD
Duke University
Gillian Sanders PhDECRI InstituteKaren Schoelles, MD, SMJohns Hopkins UniversityEric B. Bass, MD, MPHMcMaster UniversityParminder Raina, PhD Oregon Health & Science Univ.Mark Helfand, MD, MPHRTI International/ UNCMeera Viswanathan, PhD
Southern California RAND
Paul Shekelle, MD, PhD
Tufts University--NEMC
Joseph Lau, MD
University of Alberta
Terry P. Klassen, MD, MSc
Brian H. Rowe, MD, MSc
University of Connecticut
C. Michael White, PharmD
Minnesota
Robert L. Kane, M.D.
Timothy J. Wilt, MD, MPH
University of Ottawa
David Moher, PhD
Vanderbilt University
Katherine Hartman, MD, PhD Slide3
Duke EPC Project Portfolio
1. Cardiovascular
disease topic identification
11. Noninvasive positive pressure ventilation for acute respiratory failure2. Atrial fibrillation: Treatment12. Diagnosis and management of chronic cough3. Atrial fibrillation: Stroke prevention13. Pulmonary aterial hypertension4. Future research needs: ACEIs and ARBs in essential hypertension
14. Methods
modules for diagnostic test evaluation
5. Non invasive testing for coronary artery disease in women
15. Oral contraceptive use for the Primary Prevention of Ovarian Cancer
6. Treatment of coronary artery
disease in women
16. Screening for postpartum depression
7. Treatment
strategies for p
eripheral artery
disease
17. Disease-modifying anti-rheumatic drugs (DMARDS) in children with Juvenile Idiopathic Arthritis
8. Antiplatelet and anticoagulant treatments for unstable angina for UA/NSTEMI
18. Enabling healthcare decision making through clinical decision support and knowledge management
9. Transitions of care for stroke
and MI
19.
Closing the quality gap series: The medical home
10. ECG
signal-based analysis
20. Treatment of serious
mental illnessSlide4
Composition of Project TeamsStaff
Project Leader
Project Coordinator
EditorMedical Librarian
Investigators (4-8)EPC OversightPrincipal InvestigatorCo-investigators (clinical)Co-investigators (methodological)Statistical investigatorSlide5
Other Potential RolesKey informants
Technical expert panel
Peer reviewerSlide6
Gillian D Sanders, PhD
EPC Director
Rowena J Dolor MD, MHS
EPC Associate Director
Rebecca Gray, DPhilLiz Wing, BS, MAEPC EditorsRachael Posey, MSLSSenior Data Tech
Mike Musty, BA
Research Analyst
Julian Irvine, MCM
Research Analyst
Amy Kendrick RN, MSN, MS-CRM
EPC Manager
RhaShawn
Wells
Business Development Associate
Juanita Daniels
Financial Analyst
Connie Schardt, MLS
Megan Von Isenburg, MLS
Scientific Librarians
Alice Thacher, MBA
Research Aide
Amanda
McBroom, PhD
Project Leader II
Beverly Perkins, AD
Administrative
Assistant
Project
Principal Investigators
Project
Co-Investigators
Karen
Pendergast, MPH
Project Leader I
TBD
Research Aide
Corey Hadley, MM
Statistician
Brooke
Heidenfelder, PhD
Project Leader I
Duke University: EPC Organizational ChartSlide7
Investigators on Current EPC Projects
Cardiology
Adrian Hernandez
Bimal
ShahChiara MelloniGalen WagnerJeffrey WashamJudson WilliamsKaren AlexanderManesh PatelMatthew BrennanMonique AndersonRenato LopesSana Al-KhatibSreekanth
Vemulapalli
Sumeet
Subherwal
William Schuyler
Zubin
Eapen
Pulmonary
Bill
Hargett
Chris Cox
Chris Castillo
Daniel
GrilstrapJoe GovertNjira LudugoGeneral Internal MedicineRowena DolorAdia Ross
Benjamin PowerDavid MatcharDoug McCrory
George JacksonJohn WilliamsKaren AlexanderKristine SchmidtLori Bastian
Matt CrowleyRanee ChatterjeeWill YancyNeurology
Carmelo GraffigninoDai Wai OlsonPediatricsAlex Kemper
Heather VanMaterFamily MedicineDavid Lobach
Remy CoeytauxNursingJanet Prvu Bettger
Kathy WoodOBGYN/Gyn OncologyEvan MyersGeeta
SwamyLaura HavrileskyJeff LoweryRachel Pergallo
PsychiatryMarla WaldBill MeyersBiostatistics/HSR/PharmD
Gillian SandersAndrzej Kosinski Cindy GreenGregory Samsa
Jennifer GierischNancy Allen LapointeTrish Moorman
Vic HasselbladSlide8
Managing ConflictsMake clear up front potential conflicts – financial and intellectual
Delve down in to possible conflicts
Discuss with AHRQ/Task Order Officers
Understand that a conflict on one project doesn
’t mean the investigators will be conflicted on all projectsDiscuss other potential roles within projects/EPCUnderstand incentives for/against participatingSlide9
Building a TeamUse of fellows, housestaff, junior investigators
Building investigator relationships beyond one project
Having high-level staff to ensure positive EPC experience
Development of methodological abilities in general internists
Working with Division Chiefs to identify investigatorsEstablishing potential of comparative effectiveness research/systematic reviews as area of research focusAvailability of sustained funding (short term/ long term)Slide10
DISCUSSION/QUESTIONS