Mitchell A Avery Wesley K M Chong and Clive JenningsWhite J Am Chem Soc 1992 114 914919 Songnan Zhang 2262013 2013226 1 Mitchell A Avery 1975 BS ID: 928180
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Avery’s Total Synthesis of (+)-ArtemisininMitchell A. Avery, Wesley K. M. Chong, and Clive Jennings-White, J. Am. Chem. Soc. 1992, 114,914-919
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Slide2Mitchell A. Avery1975, B.S. Chemistry, Oregon State University; 1979, Ph.D. Organic Chemistry, University of California at Santa Cruz; 1979-1980, Postdoctoral Research Assistant, Department of Chemistry, University of California at San Diego, La Jolla, CA;1980-1981, Postdoctoral Research Associate, Department of Chemistry, Oregon State University, Corvallis, OR;1983-1990, Director, Steroids and Natural Products Program, Bio-Organic Chemistry Laboratory, Life Sciences Division, SRI International, Menlo Park, CA1982-1983, Organic Chemist, Bio-Organic Laboratory, Life Sciences Division, SRI International, Menlo Park, CA1981-1982, Research Associate, Bio-Organic Chemistry Laboratory, Life Sciences Division, SRI, International, Menlo Park, CA1990-1994, Associate Professor, Department of Chemistry, University of North Dakota, Grand Forks, ND1994-1997, Associate Professor, Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, University, MS; and Research Associate Professor, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS1997-present , Research Professor, Research Institute of Pharmaceutical Sciences and National Center for the Development of Natural Products, University of Mississippi, University, MS
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Slide3Artemisinin is first isolated from the plant Artemisia annua, which is a Chinese traditional medicine herb used for more than two thousand years.Artemisinin is used as a drug for treatment of the malaria.This peroxide is believed to be responsible for the drug's mechanism of action. Few other natural compounds with such a peroxide bridge are known.In 1992 Avery’s group reported their optimized TS for Artemisinin.
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Slide810 linear steps with 2.8% yield 2013-2-268
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Slide10Thank you!2013-2-2610