Mononegavirales (non-segmented, – - PowerPoint Presentation

Slide1

Mononegavirales

(non-segmented, –

ssRNA

viruses)

Bornaviridae

Bornavirus

genus

Filoviridae

Marburg-, Ebola

-,

Cuevavirus

genus

Paramyxoviridae

Respiro

-,

Morbilli

-,

Rubula

-,

Avula

-,

Henipa

-,

Ferla-

,

Aquaparamyxovirus

genus

Pneumoviri

d

ae

Orthop

neumo

-,

Metapneumovirus

genus

Rhabdoviridae

Vesiculo

-,

Lyssa

-,

Ephemero

-,

Novirhabdovirus

genus

Slide2

Paramyxoviridae

(para – like,

myxa

– mucus)

G

enera

:

Respiro

-,

Morbilli

-,

Rubula

-,

Avula

-,

Henipa

-,

Ferla-

,

Aquaparamyxovirus

Morphology:

-

ss

RNA genome

helical capsid

enveloped, ~200 nm

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Paramyxoviridae

(para – like,

myxa

– mucus)

Ge

nera

:

Respiro

-,

Morbilli

-,

Rubula

-,

Avula

-,

Henipa

-,

Ferla-

,

Aquaparamyxovirus

Morphology:

-

ss

RNA genome

helical capsid

enveloped, ~200 nm

Resistance: weak (pH, heat, detergents)

Biological properties:

Baltimore V. – viral transcriptase

proteins:

HN –

hemagglutinin

and neuraminidase activity

F – fusion proteins

CPE: cytoplasmic inclusion bodies, syncytia, h

a

emadsorption

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Paramyxoviridae

(para – like,

myxa

– mucus)

G

enera

:

Respiro

-,

Morbilli

-,

Rubula

-,

Avula

-,

Henipa

-

Ferla-

,

Aquaparamyxovirus

Morphology:

-

ss

RNA genome

helical capsid

enveloped, ~200 nm

Resistance: weak (pH, heat, detergents)

Biological properties:

Baltimore V. – viral transcriptase

proteins:

HN –

hemagglutinin

and neuraminidase activity

F – fusion proteins

CPE: cytoplasmic inclusion bodies, syncytia, h

a

emadsorption

Respiro

-,

Rubula

-,

Avula

-,

Henipavirus

:

euryxen

Morbillivirus

,

Pneumovirinae

: more

stenoxen

Slide7

Antigenic properties:

good antigens

cross-reactions within genera (

Morbillivirus

genus)

Diagnosis:

isolation, HA, IF

indirect: VN, HAI

Respirovirus

genus

:

(respiratory disease)Parainfluenza virus 1human influenza-like diseaseParainfluenza virus 3cattle, sheep – shipping fever

Slide8

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Antigenic properties:

good antigens

cross-reactions within genera (

Morbillivirus

genus)

Diagnosis:

isolation, HA, IF

indirect: VN, HAI

Respirovirus

genus

:

(respiratory disease)Parainfluenza virus 1human influenza-like diseaseParainfluenza virus 3cattle, sheep – shipping fever

human influenza-like disease

Sendai virus

rodents, rabbit

pneumonia, encephalitis

Slide10

Morbillivirus genus

:

(morbilli – measles)

Canine distemper virus

dog, bear, mink, lion, tiger, jaguar...

acute: fever, respiratory

signs

subacute, chronic: encephalitis

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Morbillivirus genus

:

(morbilli – measles)

Canine distemper virus

dog, bear, mink, lion, tiger, jaguar...

acute: fever, respiratory

signs

subacute, chronic: encephalitis

Phocine distemper virus

seal – fever, pneumonia

Slide14

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Morbillivirus genus

:

(morbilli – measles)

Canine distemper virus

dog, bear, mink, lion, tiger, jaguar...

acute: fever, respiratory symptoms

subacute, chronic: encephalitis

Phocine distemper virus

seal – fever, pneumonia

Cetacean morbillivirus

whale, dolphin – fever, pneumonia

Rinderpestruminants – fever, hemorrhage, mucosal erosions

Slide16

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Morbillivirus genus:

(morbilli – measles)

Canine distemper virus

dog, bear, mink, lion, tiger, jaguar...

acute: fever, respiratory

signs

subacute, chronic: encephalitis

Phocine distemper virus

seal – fever, pneumonia

Cetacean morbillivirus

whale, dolphin – fever, pneumonia

Rinderpestruminants – fever, hemorrhage, mucosal erosionssince 2012 the Earth is free from RinderpestPeste des petits ruminantssheep, goat ~ Rinderpest

Slide19

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Morbillivirus

genus:

(

morbilli

– measles)

Canine distemper virus

dog, bear, mink, lion, tiger, jaguar...

acute: fever, respiratory signs

subacute

, chronic: encephalitis

Phocine

distemper virusseal – fever, pneumoniaCetacean morbilliviruswhale, dolphin – fever, pneumoniaRinderpestruminants – fever,

hemorrhage

, mucosal erosions

since 2012 the Earth is free from

Rinderpest

Peste

des

petits

ruminants

sheep, goat ~

Rinderpest

Feline

morbillivirus

g

l

omerulonephritis

Measles (

morbilli

)

human – fever, rash

Slide21

Rubulavirus genus:

(Rubula inflans – mumps)

Parainfluenza virus 2

dog – kennel cough (with CAV-2 and

B. bronchiseptica

)

human – influenza-like disease (different from the canine)

Parainfluenza virus 4

human – influenza-like disease

Simian parainfluenza virus

Mumps

human – salivary gland swellingorchitis, mastitis, encephalitisAvulavirus genus: (avis)Newcastle disease (avian paramyxovirus 1)euryxen – birds, zoonosis

virulence variants: lento-, mezo-, velogen strains

viscerotrop form: hemorrhage, high mortality

neurotrop form: encephalitis

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Rubulavirus genus:

(Rubula inflans – mumps)

Parainfluenza virus 2

dog – kennel cough (with CAV-2 and

B. bronchiseptica

)

human – influenza-like disease (different from the canine)

Parainfluenza virus 4

human – influenza-like disease

Simian parainfluenza virus

Mumps

human – salivary gland swellingorchitis, mastitis, encephalitisAvulavirus genus: (avis)Newcastle disease (avian paramyxovirus 1)euryxen – birds, zoonosis

virulence variants: lento-, mezo-, velogen strains

viscerotrop form: hemorrhage, high mortality

neurotrop form: encephalitis

Avian

paramyxovirus

2-9

2-6: some strains are pathogen

in pet and wild birds

7-9: orphan

Slide24

Henipavirus

genus:

Hendra

virus

horse, human, Australia – encephalitis

Nipah

virus

swine, human, Malaysia – encephalitis

Ferlavirus

genus:

Fer-de-Lance virus –snake pneumonia

Aquaparamyxovirus genus:Atlantic salmon paramyxovirus

Pneumoviri

d

ae

(

pneuma

– air)

Orthop

neumovirus

genus:

Bovine respiratory syncytial virus (RS)

severe pneumonia

interstitial emphysema

Slide25

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Henipavirus

genus:

Hendra

virus

horse, human, Australia – encephalitis

Nipah

virus

swine, human, Malaysia – encephalitis

Ferlavirus

genus:

Fer-de-Lance virus –

snake pneumoniaAquaparamyxovirus genus:Atlantic salmon paramyxovirus

Pneumoviri

d

ae

(

pneuma

–

air

)

Orthop

neumovirus

genus:

Bovine respiratory syncytial virus (RS)

severe pneumonia

interstitial emphysema

Ovine respiratory

syncitial

virus

Murine pneumonia – mice

Human respiratory syncytial virus

Metapneumovirus

genus:

Turkey rhinotracheitis virus (TRT)

Slide27

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Henipavirus

genus:

Hendra

virus

horse, human, Australia – encephalitis

Nipah

virus

swine, human, Malaysia – encephalitis

Ferlavirus

genus:

Fer-de-Lance virusAquaparamyxovirus genus: Atlantic salmon paramyxovirus

Pneumoviri

dae

(

pneuma

–

air

)

Orthop

neumovirus

genus:

Bovine respiratory syncytial virus (RS)

severe pneumonia

interstitial emphysema

Ovine respiratory

syncitial

virus

Murine pneumonia – mice

Human respiratory syncytial virus

Metapneumovirus

genus:

Turkey

rhinotracheitis

virus (TRT)

Swollen head syndrome (SHS) – chicken