PPT-Amyloidosis- What does it have to do with Myeloma?

Anita DSouza MD MS Froedtert amp MCW Cancer Center Milwaukee WI Objectives Types of amyloidosis How does amyloidosis form Why does myeloma sometimes make amyloid Treatment of amyloidosis. AL amyloidosis: involves almost every system Liver NICE Guideline. Published Feb 2016. Adults with myeloma (and plasma cell leukaemia). Excluded:. Monoclonal . gammopathy. of uncertain significance (MGUS). Amyloidosis. Solitary . plasmacytomas. Included:. . . Multiple. . myeloma. . . Amyloidosis. .. Part 2. Dr. Gábor . Mikala. Waldenström. . Macroglobulinemia. Uncontrolled proliferation of . lymphoplasmacytes. producing . IgM. Median age . 63 years. . Myeloma. Patients Europe. Disclosure. I have . nothing. . to. . disclose. , I . declare. . that. I. have . no relevant or . material. financial . interests. . that. . relate. . to. . the. A Spotlight on New Disease-Modifying . Therapies Across the Clinical Spectrum. Supported by an educational grant from Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC.. About These Slides. Introduction. Clinical Burden Associated With Lack of Recognition and Diagnosis of ATTR Amyloidosis. Patients Who Present With Peripheral Neuropathy. Clinical Examination and Diagnostic Tools to Confirm Diagnosis of hATTR Amyloidosis . . Razick. overview. Patient presentation. CC: . “I feel good”. AF is an 88-year-old female returning to the Advanced Heart Failure Clinic for a follow up appointment where she is monitored closely for her heart failure associated with a PYP scan for possible amyloidosis. . ASSTT. PROFESSOR,. DEPTT. OF PATHOLOGY, BVC, PATNA. What is amyloid. Amyloid . (G. . Amylon. . - STARCH) means starch-like. Amyloid is a pathologic glycoprotein deposited in the extracellular spaces and forms fibrils on polymerization.. . myeloma. . . Amyloidosis. .. Part 2. Dr. Gábor . Mikala. Waldenström. . Macroglobulinemia. Uncontrolled proliferation of . lymphoplasmacytes. producing . IgM. Median age . 63 years. Presents with weakness, fatigue, . . . Manoj. . Radhakrishnan. Dept. of Pathology , SKHMC. nature of . amyloid. amyloid. is a . protienaceous. substance deposited between cells in various tissues and organs in a variety of clinical settings. A Guide to Authored by Teresa Coelho, Bo - Goran Ericzon, Rodney Falk, Donna Grogan, Shu - ichi Ikeda, Mathew Maurer, Violaine Plante - Bordeneuve, Ole Suhr, Pedro Trigo 2016 Edition Edited by Merr Shifting Treatment Paradigm. Jeffrey A. Zonder, MD. Professor of Oncology, Wayne State University. Leader, Multiple Myeloma & Amyloidosis MDT. Co-Leader, Molecular Therapeutics Program. Karmanos. Amyloid is deposited predominantly in the extracellular space in various tissue and organs. With progressive accumulation, it encroaches on and produces pressure atrophy of adjacent cells. AMYLOIDOSIS. Adams D, et al. . J Neurol. . . 2021;268:2109-2122; Rozenbaum MH, et al. . Cardiol Ther. . 2021;10:141-159; Lousada I, et al. . Orphan J Rare Dis. . 2015;10:22. . Multiple misdiagnoses have been reported in up to .