Manoj Radhakrishnan Dept of Pathology SKHMC nature of amyloid amyloid is a protienaceous substance deposited between cells in various tissues and organs in a variety of clinical settings ID: 914314
Download Presentation The PPT/PDF document "Amyloidosis ..." is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
Slide1
Amyloidosis
Dr
.
Manoj
Radhakrishnan
Dept. of Pathology , SKHMC
Slide2nature of amyloid
amyloid
is a
protienaceous
substance deposited between cells in various tissues and organs in a variety of clinical settings
Starch like staining properties(PAS +
ve
)
Amorphous
eosinophilic
,hyaline extracellular substance seen under the microscope.
Although chemically diverse they share a physical property-
nonbranching
long fibrils(7.5-10mm).by electron
diffraction,they
are arranged –into beta-pleated sheaths.
Congo-red staining is typical, under polarized light they show apple green birefringence.
Slide3PAS +ve
substance
Slide4Congo red stain-apple green birefringence
Slide5Slide6chemical structure of amyloid
AL
-
Amyloid
formed by -immunoglobulin light
chains.this
form of
amyloid
is found in multiple myeloma
AA
-
Amyloid
associated
protien
synthesized by the liver [ in the form of precursor serum
amyloid
A(SAA)]
A beta-
Amyloid
found in Alzheimer disease(Beta-
amyloid
protien
)
Slide7Amyloidosis-Defn
Amyloidosis
is a group of diseases
characterised
by a
deposition of
amyloid
in various organs
.
May occur as
primary…
or
secondary
form during the course of a chronic inflammatory disease.
The disease maybe limited to a
single organ
,or
systemic
.
Some forms maybe hereditary
Slide8Primary amyloidosis
Systemic deposition of
AL type
amyloid
Assoc with
plasma cell
neoplasia
and
B cell lymphoma
Monoclonal
gammopathy
(whole
immunoglobulins
or only light chains)found by electrophoresis of serum
Slide9secondary amyloidosis
There is an underlying disease (
eg
tuberculosis,chronic
osteomyelitis,rheumatoid
arthritis and cancer)
or condition(heroin abuse)
Widespread deposition of
AA
Protien
Slide10Amyloidosis of aging
Systemic deposition of
amyloid
in elderly patients (seventh and eighth decade)
Type of
amyloid
–A-beta
Frequent
involvement of heart(cardiac
amyloidosis
)
Slide11systemic amyloidosis
Kidneys
: typically enlarged ,pale and
waxy.glomerular
mesangial
, interstitial and vascular wall depositions of
amyloid
.
spleen
: enlargement (
splenomegaly
) with either nodular depositions(sago spleen) or
maplike
(red pulp) depositions (lardaceous spleen)
Liver
:
hepatomegaly,extracellular
amyloid
with pressure atrophy of
hepatocytes
Small blood vessels
in many organs contain deposits of
amyloid
.
Amyloid
deposits in blood vessels can be observed in gingival or rectal biopsies
Slide12Slide13sago spleen
Slide14lardaceous spleen
Slide15Slide16liver
Slide17Slide18