PPT-Uric acid M.s.c. Huda Raad Karim

Uric acid is formed from the breakdown of nucleic acids and is an end product of purine metabolism Uric acid is transported by the blood from the liver to the kidney where it is filtered Renal excretion accounts for 75 of uric acid elimination the remainder of uric acid passes into the GI tract . One of the important specialized pathways of a number of amino acids is the synthesis of purine and pyrimidine nucleotides. . These nucleotides are important for a number of reasons. Most of them, not just ATP, are the sources of energy that drive most of our reactions.. Drugs Used in Gout. The selective COX-2 inhibitors are a new group of drugs that provide potent . antiinflammatory. activity without causing significant . GI toxicity. . Celecoxib , . the first selective . Heart of England NHS Foundation Trust. Overview. Background. Diagnosis. Risk factors. Acute treatment. Long-term treatment. Pseudogout. Gout. Inflammatory arthritis due to monosodium urate crystal deposition. Dr.. Anil Kumar. (Medicine) Asst. Professor. . Dept. of VCC. GOUT. Introduction:. The term . “gout” . in general term refers to a form of inflammatory arthritis.. Oussama Hassan, MD. ERA-EDTRA Fellow. Royal London Hospital - . Barts. Health NHS Trust, . London, . UK. Overview of uric acid. History! . Definition. There is no universally accepted definition of . It is the end product of metabolism of purines which are present in nucleic acids of nucleoproteins . It is formed endogenously from nucleoproteins and exogenously from metabolism of purines taken in food. Lifestyle Change in Patients with . Hyperuricemia. Subtitle. The amount of . urate. in the body, . depends . on the balance between dietary intake, synthesis, . and excretion.. .  . Hyperuricemia. Pathology Of Gouty Nephropathy. Uric acid crystals and . urates. are deposited in the kidney.. This leads to irritation and acute . inflammation,more. time, more deposition.. This deposits act as . Acid. M.sc.. . Duaa. . falah. pharmacology and toxicology. Uric acid. It is . the final breakdown product of purine metabolism. it circulates in the plasma as sodium urate and is excreted by the kidney. It is derived from nucleic acid that are ingested or come from destruction of tissue cell .. Gout is a systemic disease caused by excess uric acid as the result of deficient purine metabolism. Clinically, gout is marked by peripheral arthritis and painful inflammation in joints resulting fro Shemeri. Introduction. Uric acid is the product of catabolism of the purine nucleic acids. Although it is filtered by the . glomerulus. and secreted by the distal tubules into the urine, most uric acid is reabsorbed in the proximal tubules and reused.. excretion and urea cycle; regulation of urea cycle;. Nitrogen excretion:. Nitrogen excretion means elimination of nitrogen containing compounds from an organism.. Urine is the main rout for such excretion, also take place through feces.. to Find a Ligand that Will Bind to Xanthine . Oxidase. Lysengkeng Her and Thao Yang. Department of Chemistry, University Wisconsin-Eau Claire, Eau Claire WI. Celebration of Excellence in Research and Creativity (CERCA), April 25-29, 2016. . Define gout . Describe outlines of treatment. Describe treatment of acute gouty arthritis . Describe the mechanism of action , clinical uses & side effects of drugs used in acute attacks. OBJECTIVES ( continue).