P ain M anagement in Acute Myocardial Infarction (AMI) - PowerPoint Presentation

Slide1

Pain Management in Acute Myocardial Infarction (AMI)

PICO Question

In

adults with

Opium

addiction, presenting with Acute

Myocardial Infarction (AMI)

,

what is the

benefit of

pain management

with

alternatives

analgesics compared To morphine?

PICO Question

P

roblem

or population 

:Opium addict Adult Patients that suffer from Acute Myocardial Infarction Pain

I

ntervention: Use

alternatives analgesics

are available Except Morphine

for

AMI patients.

C

omparison

:

comprehensive

evaluation of the rationality of administration of morphine in AMI, and

other

available

analgesics .

O

utcome: according

side

effects and drug-drug interactions of

morphine,

alternatives

analgesics have less

interactions

with the present patient condition.

Since the turn of the twentieth century, morphine, an opioid analgesic, has played an integral role in the management of pain in myocardial infarction (MI).

This is attributed to morphine’s effect on

reducing blood pressure

,

slowing heart rate

, and

relieving anxiety

, which may

decrease myocardial oxygen demand

, added to the fact that morphine has been studied extensively in pain management in many

settings.

However, observational data suggest that morphine administration during acute myocardial infarction (AMI) may have negative consequences. a recent evidence uncovered that morphine may impede gastrointestinal

absorption

of oral antiplatelet drugs important in reducing mortality in AMI

.

We

discuss the rationality of morphine use according to recent evidence and the

side effects

and

drug-drug interactions

of morphine affecting MI

patient

Compared

with

the

present alternatives

based on the findings of experimental, observational and randomized clinical studies.