PDF-Brit.J.Pharmacol.(196),22,463-477.MECHANISMOFTHEPARALYSINGACTIONOFPIPE

Author : sherrill-nordquist | Published Date : 2017-03-02

464JDELCASTILLOWCDEMELLOandTMORALESjunctionsbutbyrhythmicspikepotentialsgeneratedbypacemakersinthemusclemembraneitselfAcetylcholinedepolarizesthemusclecellstherebyincreasingthefrequencyofthespi

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Brit.J.Pharmacol.(196),22,463-477.MECHANISMOFTHEPARALYSINGACTIONOFPIPE: Transcript

464JDELCASTILLOWCDEMELLOandTMORALESjunctionsbutbyrhythmicspikepotentialsgeneratedbypacemakersinthemusclemembraneitselfAcetylcholinedepolarizesthemusclecellstherebyincreasingthefrequencyofthespi. D.G.SHANDagents,nicotine,tetramethylammonium,carbacholandacetylcholine,hadqualitativelythesameactionasthatdescribedbyEccles(1956)ontheisolatedsuperiorcervicalganglionoftherabbitandbyPaton&Perry(1953)f ANTAGONISTSOFACETYLCHOLINEANDADRENALINE120120116116108108120116108100560AIi4102040100200Acetylcholine(ng;mX.)Fig.1.Effectofacetylcholineonthecontractionsandrateoftheguinea-pigisolatedatrium.Acetylchol H.-O.SCHILDPlanofexperiments.-Theobjectoftheseexperimentswastofindoutwhetherdrugscouldbedifferentiatedbytheirresponsestoantagonists.Theywereaccordinglydesignedtotestwhethertheeffectsoftwogivenstimulan W.G.DEWHURSTandE.MARLEYwasflangedandtaperedtofittightly;acrystalmicrophone(AcosMic38)wasattachedinside.Acontrolbox(amirrorimageoftheexperimentalboxbutotherwiseidentical)wasplacedsothatthetransparentsi K.P.BHARGAVA,OMCHANDRAandD.R.VERMAThedogswereobserveduntiltheyvomitedorforaperiodof2hr.Theoralemeticdosewasestimatedindogswhichhadfastedfor18hrpreviously.Thedoseofsodiumsalicylatewasdissolvedin25ml.of A.S.MILTONTheventricleswerestimulatedbyplatinumelectrodes,onepiercingthewalloftheleftventricleattheapex,andtheothernearthebasemidwaybetweentheoriginsoftherightandleftcoronaryarteries.Whenstimulationwa --I~~~~~~~~I~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~390G.FAWAZandB.TUTUNJIN+Io'ItOHll~~~~~~1-,t00Ner-,motU*rr5t.Cdz04.90.Z-=ZCdCdboCdZ:t'.3w_._c0.CZCdS._01-1x~rCo,,-H1-11-1(?a, ANALGESICSANDCAPILLARYPERMEABILITYofthetestandsotodistinguishbetweentheeffectsofnarcoticandnonnarcoticanalgesics.METHODSMaleandfemalespecificpathogen-freemiceoftheAlderleyParkstrainI,weighing20 BRIT CMYK TCK 5 KIT FOR THE PREPARATION OF Tc-SULPHUR COLLOID (DIAGNOSTIC- FOR INTRAVENOUS USE) The kit for the preparation of Tc-Sulphur colloid is a three-component kit. Onand suitable for i.v. admi D.G.SHANDagents,nicotine,tetramethylammonium,carbacholandacetylcholine,hadqualitativelythesameactionasthatdescribedbyEccles(1956)ontheisolatedsuperiorcervicalganglionoftherabbitandbyPaton&Perry(1953)f R.JAQUESandM.SCHACHTERTABLEIRELEASEOFHISTAMINEFROMPERFUSEDCATSKINFOLLOWINGTHEINTRA-ARTERIALINJECTIONOFSEAANEMONETENTACLEEXTRACT(THALASSINE)AmountofThalassineTotalHistamineAmoutofThalssmeCollectedinPer COCAINEANDNORADRENALINEUPTAKEMETHODSMaleorfemalerats,weighing170to250g,wereanaesthetizedwithether,pithedandmaintainedbyartificialrespiration(Muscholl&Vogt,1957).Thebloodpressurewasrecordedfromthecarot bradykinin. B. 2. receptor that extends molecular/cellular studies: . the isolated umbilical vein. . François Marceau. Professeur associé. Importance of . bradykinin. (BK). Derived. . from. . Indian J Physiol Pharmacol 2007; 51(2)Aspirin Resistance111and COX-2 expression or a novel platelet biosynthesis which would remain from cells in the 112Ashwin et alIndian J Physiol Pharmacol 2007;

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