Dr Stephen Falk - PowerPoint Presentation

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Dr Stephen Falk - PPT Presentation

Clinical Director CRN West of England SWAG SSG Colorectal Meeting Wednesday 30 th November 2016 Clinical Research Network West of England Clinical Research Network amp Cancer Services West ID: 585542

studies hospitals 2018 cancer hospitals studies cancer 2018 bristol portfolio university nihr research open clinical nhs 2017 colorectal commercial

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Slide1

Dr Stephen Falk

Clinical Director CRN West of England

SWAG SSG Colorectal MeetingWednesday 30th November 2016

Clinical Research Network

West of EnglandSlide2

Clinical Research Network & Cancer Services

West

ofEngland

SWAG - Somerset Wiltshire Avon & GloucestershireSlide3

NIHR CRN High Level Objectives

Increase number of participants into NIHR CRN portfolio studies650,000 in England21,905 in West of EnglandIncrease the number of studies that deliver to time and targetTarget 80%

Increase number of commercial studies delivered through network650 new studies this year75% of all commercial studiesReduce NHS study set up timesReduce time taken to recruit first participantSlide4

NIHR CRN Objectives for cancer

Recruit 20% of cancer incidenceWest of England 1,909Recruit 7.5% of cancer incidence into interventional studies716Include challenging studiesCancer surgery – 4 recruits per 100,000 population

Radiotherapy – 6 recruits per 100,000 populationRare cancers (<6 per 100,000) – 12 recruits per 100,000 populationChildren & young people – 3 per 100,000 populationTeenagers & young adults – record number of 16-25 year olds participating in research Slide5

Why do research ?

Adjusted survival curves for patients treated in institutions with high research participation.

Amy Downing et al. Gut doi:10.1136/gutjnl-2015-311308

6Slide7

UK landscape

Political commitment to supporting life-sciences industry

Health & Social Care Act 2012 / NHS Constitution 2013

Embed clinical research in all aspects of care

Clinical Research NetworkSlide8

UK v Europe 2016

Data source:

http://clinicaltrials.gov/

Germany

United

Kingdom

France

Spain

Italy

(All Phase II, III, IV studies received from 01/04/2015 to 31/03/2016 funded by Industry)Retrieved online on 07/09/2016 Clinical Research NetworkSlide9

The evidence: increased volume

Number of

new

commercial studies added to the NIHR CRN PortfolioSlide10

The evidence: recruitment

146,664

patients recruited to industry studies over the last 6 years

34,339

patients recruited to commercial contract studies in 15/16

16 first global patients

in 2015/16

13 first European patients

in 2015/16

Number of participants into commercial NIHR CRN Portfolio studiesSlide11
Slide12

% Recruitment of cancer incidence to interventional studies by Local Clinical Research Network 2016-17Slide13
Slide14
Slide15

Open studies in SWAG – Colorectal Cancer

BRAG

Open studies

Black

Study not reported recruitment or study has not recruited

Red

% Recruitment is more than 30 behind % time elapsed, i.e. Difference < -30

Amber

% Recruitment is less than 30 behind % elapsed time but more than 0 behind % elapsed time,

i.e. -30 < Difference < 0

Green

% Recruitment is equal to or greater than % elapsed time, i.e. Difference >= 0

Grey

Unable to calculate RAG due to record missing at least one data point

All open studies at present are non-commercial

Portfolio ID

Project Title

Site

Principal Investigator

BRAG Rating

Recruit-ment

Site Target

Planned End Date

1269

NSCCG

Gloucestershire Hospitals

Benstead, Dr Kim

-34.77%

154

300

30/09/2018

1269

NSCCG

Great Western Hospitals

Blesing, Dr Claire

779.36%

130

30/09/2018

1269

NSCCG

North Bristol NHS Trust

Lyons, Ms Ann

487.93%

211

30/09/2018

1269

NSCCG

Royal United Hospitals Bath

Milsom, Mrs Carey

138.51%

226

100

30/09/2018

1269

NSCCG

University Hospitals Bristol

Falk, Dr Stephen J

10.88%

253

258

30/09/2018

1269

NSCCG

Weston Area Health NHS Trust

Muldoon, Annie

4212.60%

215

30/09/2018Slide16

Open studies in SWAG – Colorectal Cancer

Portfolio ID

Project Title

Site

Principal Investigator

BRAG Rating

Recruitment

Site Target

Planned End Date

1269

NSCCG

Taunton and Somerset FT

Beaumont, Erica

131

120

30/09/2018

1269

NSCCG

Yeovil District Hospital

Sephton, Dr Matthew

30/09/2018

3771

FOxTROT

Great Western Hospitals

Lowndes, Dr Sarah

-35.01%

31/03/2018

3771

FOxTROT

North Bristol NHS Trust

Lyons, Ms Ann

12.47%

31/03/2018

3771

FOxTROT

Royal United Hospitals Bath

De Winton, Dr Emma

127.77%

31/03/2018

3771

FOxTROT

University Hospitals Bristol

Thomas, Michael G

-57.65%

31/03/2018

3771

FOxTROT

Weston Area Health NHS Trust

Hilman, Dr Serena

-160.10%

31/03/2018

3771

FOxTROT

Taunton and Somerset FT

Barlow, Dr Clare

31/03/2018

3771

FOxTROT

Yeovil District Hospital

Sephton, Dr Matthew

-3

31/03/2018Slide17

Open studies in SWAG – Colorectal Cancer

Portfolio ID

Project Title

Site

Principal Investigator

BRAG Rating

Recruitment

Site Target

Planned End Date

7590

CORGI

University Hospitals Bristol

Donaldson, Dr Alan

-29.40%

100

31/05/2026

7890

Aristotle

Gloucestershire Hospitals

Benstead, Dr Kim

-90.50%

21/09/2016

7890

Aristotle

Great Western Hospitals

Blesing, Dr Claire

-53.90%

21/09/2017

7890

Aristotle

University Hospitals Bristol

Falk, Dr Stephen J

-32.99%

31/10/2017

7890

Aristotle

Taunton and Somerset FT

Beaumont, Dr Erica

21/09/2017

7890

Aristotle

Yeovil District Hospital

Beaumont, Dr Erica

21/09/2017

8078

MERCURY 2

Weston Area Health NHS Trust

Pye, Mr Geoff

-148.55%

30/09/2015

8882

Raman colon diagnostics

Gloucestershire Hospitals

Kendall, Dr Catherine

-18.28%

30/09/2016Slide18

Open studies in SWAG – Colorectal Cancer

Portfolio ID

Project Title

Site

Principal Investigator

BRAG Rating

Recruitment

Site Target

Planned End Date

9018

Pulmonary Metastasectomy in Colorectal Cancer (PulMICC)

University Hospitals Bristol

Batchelor, Tim

302.74%

30/04/2020

9340

Predisposition to serrated neoplasia and tumours (PRESENT) study

University Hospitals Bristol

Tomlinson, Prof Ian

-91.98%

31/05/2017

14777

Hughes Abdominal Repair Trial (HART)

Royal United Hospitals Bath

Williamson, Mr Mike

-3.36%

30/03/2018

14777

Hughes Abdominal Repair Trial (HART)

Weston Area Health NHS Trust

West, Mr Reuben

-39.29%

31/03/2017

14777

Hughes Abdominal Repair Trial (HART)

Yeovil District Hospital

Francis, Mr Nader

-17

31/03/2017

15958

InterAACT - A Multicentre Randomised Phase II Advanced Anal Cancer Trial

Great Western Hospitals

Lowndes, Dr Sarah

-94.77%

31/12/2016

15958

InterAACT - A Multicentre Randomised Phase II Advanced Anal Cancer Trial

University Hospitals Bristol

Falk, Dr Stephen

-12.01%

30/06/2017Slide19

Open studies in SWAG – Colorectal Cancer

Portfolio ID

Project Title

Site

Principal Investigator

BRAG Rating

Recruitment

Site Target

Planned End Date

14893

FOCUS 4

Gloucestershire Hospitals

Benstead, Dr Kim

46.99%

01/01/2019

14893

FOCUS 4

Great Western Hospitals

Lowndes, Dr Sarah

-40.40%

01/01/2019

14893

FOCUS 4

Royal United Hospitals Bath

De Winton, Dr Emma

182.05%

01/01/2019

14893

FOCUS 4

University Hospitals Bristol

Falk, Dr Stephen J

-15.41%

01/01/2019

14893

FOCUS 4

Weston Area Health NHS Trust

Hilman

, Dr Serena

01/01/2019

14893

FOCUS 4

Taunton and Somerset FT

Barlow, Dr Clare

-11

01/01/2019

14893

FOCUS 4

Yeovil District Hospital

Sephton, Dr Matthew

109

01/01/2019Slide20

Open studies in SWAG – Colorectal Cancer

Portfolio ID

Project Title

Site

Principal Investigator

BRAG Rating

Recruitment

Site Target

Planned End Date

16024

Does aspirin increase the clinical response to chemoradiotherapy?

North Bristol NHS Trust

McCarthy, Ms Kathryn

-87.73%

31/01/2017

16024

Does aspirin increase the clinical response to chemoradiotherapy?

Royal United Hospitals Bath

Cox, Dr Richard Ashley

308.32%

31/01/2017

16024

Does aspirin increase the clinical response to chemoradiotherapy?

University Hospitals Bristol

Thomas, Michael

-63.18%

31/01/2017

17006

IMPRESS

Taunton and Somerset FT

Beaumont, Erica

-11

31/08/2019

17006

IMPRESS

Yeovil District Hospital

Beaumont, Dr Erica

-24

31/08/2019

30901

3D vs 2D laparoscopic rectal surgery

Yeovil District Hospital

Francis, Mr Nader

31/12/2017Slide21

Studies in set up –Colorectal Cancer

Portfolio ID

Study Title

Project Type

Site

20576

TRIGGER -

Magnetic Resonance Tumour Regression Grade (mrTRG) As A Novel Biomarker To Stratify The Management Of Good And Poor Responders To Chemoradiotherapy: A Rectal Cancer Multicentre Randomised Control Trial

Non-Commercial Interventional

University Hospitals Bristol

31184

PLATO - PersonaLising Anal cancer radioTherapy dOse

Non-Commercial Interventional

University Hospitals Bristol

Falk, Dr Stephen

31203

STAR-

TReC

- Can we Save the rectum by watchful waiting or

TransAnal

surgery following (chemo)Radiotherapy versus Total

mesorectal

excision for early

REctal

Cancer?

Non-Commercial Interventional

University Hospitals Bristol

Slide22
Slide23

Useful links

https://www.crn.nihr.ac.uk/National and local network information including training programmes templates, tools, contacts, videos etc

https://odp.nihr.ac.uk/ http:/Open data platform. Look at performance across whole CRN including all specialty areas/csg.ncri.org.uk/portfolio/portfolio-maps/View current national portfolio of open, closed and ‘in set up’ cancer studies https://www.ukctg.nihr.ac.uk/See where a study is open across the country

http://public-odp.nihr.ac.uk/ Search for a study to fit criteria. Good for horizon scanning, eligibility criteriaSlide24

Contacts

Research Delivery Manager – maxine.taylor@nihr.ac.ukCancer portfolio facilitator – sarah.west@nihr.ac.uk