PPT-Genome-wide Association Study

BIOST 2055 04012015 Human Genome and Single Nucleotide Polymorphisms SNPs 23 chromosome pairs 3 billion bases A single nucleotide change between pairs of chromosomes Eg Haplotype1 AAGG. The mission of the American He art Association is to build healthier lives free of cardiovascular disease and stroke These diseases remain the No1 and No4 killers of Americans respectively A leading priority of the AHA is to fund research that incre Presented by Karen . Xu. What you need to know. Basic genetic concepts behind GWAS. Genotyping technologies and common study designs . Statistical concepts for GWAS analysis. Replication, interpretation and follow-up of association results. Lecture 1: Introduction. Linkage studies. Traditional approach to identifying genes for human traits and diseases was through linkage.. For . Mendelian. diseases (e.g. Huntington’s disease) there is a clear co-segregation of genetic markers with disease within pedigrees.. Nadia Khan, Rick Smith, . and Anna . Kuperman. Epigenetics 2012. Introduction. Most Genome Wide Approaches were adapted from technologies originally developed for detecting methylation at the level of a single gene. Younghun. Han. Department of Epidemiology. UT MD Anderson Cancer Center. Outline. Introduction. GeneABEL. : . GWAA.data. class. Importing data to . GenABEL. Genetic data QC. GWA association analysis. metritis. in U.S. Holstein cattle . (Paper 610). J.B. Cole,*. 1. K.L. Parker Gaddis,. 2. D.J. Null,. 1. C. Maltecca,. 3. and J.S. Clay. 4. 1. Animal Genomics and Improvement Laboratory, ARS, USDA, Beltsville, MD, USA. Boyang. . Li, Ke Xu. June 8. , 2018. VACS MVP Beta Project. Background. MVP smoking GWASs. Downstream analyses. - Genetic . correlation. - Heritability enrichment. Summary. Biostatistics | Yale School of Public Health. Bas E. Dutilh. March 4. th. 2013. Protein function. Phenotypic. . function. E.g. . apoptosis. GO: . Biological. . process. Cellular. . function. E.g. . ribosome. GO: . Cellular. component. Molecular. High Throughput Sequencing. TexPoint fonts used in EMF: . A. A. A. A. A. A. A. A. A. A. A. A. A. A. A. A. David Tse. U.C. Berkeley. ITA . Feb , 2013. Research supported by NSF Center for Science of Information.. Genomics Lesson 12_1. Ross . Hardison. 4/19/15. 1. Genetic association. The occurrence together in a population, more often than can be readily explained by chance, of two or more traits of which at least one is known to be genetic.. Kesheng Wang, PhD. Department of Biostatistics and Epidemiology. College of Public Health. East Tennessee State University. 2. Outline. Introduction . Alcohol dependence (AD). Genetic study. . Subjects and Methods. T.H. Beaty. FaceBase. Meeting. June 5, 2010. Pittsburgh PA. A bit of background. Both cleft lip with/without cleft palate (CL/P) & cleft palate (CP) show strong familial aggregation. Twin & family studies show clear evidence of genetic control. 2017. ggibson.gt@gmail.com. http://www.cig.gatech.edu. Outline. General . overview of association . studies. Sample Results. Three steps to GWAS:. Primary scan. Replication. Fine mapping. Individual Site Score. emm1. invasive Group A . Streptococcus. isolated from Belgian patients during 1994˗2013 . J. Coppens. 1. , . B. B. . Xavier,. . J. Sabirova. 1. , C. Lammens. 1. , K. Loens. 2. , S. Malhotra-Kumar.