PPT-Objectives Cover some of the essential concepts for GWAS that have not yet been covered

HardyWeinberg equilibrium Metaanalysis SNP Imputation Review what we have learned about the genetics of common disease from GWAS Where do we go from here What do we go with GWAS results functional characterization of GWAS loci. HapMap. Peter Castaldi. January 29, 2013. Objectives. Introduce the concept of linkage disequilibrium (LD). Describe how the . HapMap. project provides publically available information on genetic variation and LD structure. World’s Oldest Human. Jeanne Calment . of Arles, France. 1875-1997. 122 . yrs. Longevity. is Heritable. From Gross L., 2006. Helen Reichert and siblings, as children and centenarians. Mollye. Marcus, 111 years old, and family. Presented by Karen . Xu. What you need to know. Basic genetic concepts behind GWAS. Genotyping technologies and common study designs . Statistical concepts for GWAS analysis. Replication, interpretation and follow-up of association results. IGSS 2015 Tutorial. Ben . Domingue. Gameplan. Overview. What are polygenic scores?. How are they used?. How are they created?. You create them.. Top hits. Homebrewed Genome-wide. PRSice. . Caveats, etc.. Clinical Immunology. March 26, 2013. HARVARD. MEDICAL SCHOOL. Overview. Clinical characteristics and pathophysiology. Differential diagnosis. Exam and laboratory studies. Treatment strategy. Research opportunities. Jeff Barrett. What are the goals of disease genetics?. For a given disease, we would like to:. Predict if someone will get sick, how bad it will be, and what treatment will work.. Test hypotheses about relationships to other diseases and traits.. Matt . Hudson . Crop Sciences. NCSA. . HPCBio. IGB. University . of Illinois. Outline. How do we predict molecular or genetic functions using variants?. Predicting . when a coding SNP or SNV is “damaging”. via . Mining . GWAS S. tatistics . Yue. Wang, . Xintao. Wu and . Xinghua Shi. College of Computing and Informatics, . University of North Carolina at Charlotte . Background. Data . privacy in genome-wide association studies (GWAS) is . for Colorectal . Cancer. Ulrike (. Riki. ) Peters. Fred Hutchinson Cancer Research Center. University of Washington. Overview. Significance and rationale. . Current efforts on rare and less frequent variants. There\'s a reason the words fresh and cool come to mind when thinking of peppermint. Peppermint comes from the blending of watermint and spearmint, and has a very strong, minty flavour and scent that is exquisitely refreshing. It tastes delicious, which is why it is commonly paired with chocolate and other desserts or candies, but you’ll also find peppermint in all sorts of cosmetics, including soaps, shampoos, face scrubs, toothpastes and mouthwash. If you were to ask ten people what they love about essential oils and why they actively choose to incorporate them into their daily routine, each person would have a different answer. That is because every essential oil offers a range of health and wellness benefits for your body and mind, and they are all as unique as the person using them. Under the Produce Safety Rule overed produce is defined as fruits and vegetables that are typically consumed raw Produce not covered by the Produce Safety Rulehas been identified by the Examples of o genetic variants. BMMB 551 Genomics. Ross . Hardison. 4/7/15. 1. Published. GWA Reports, 2005 . – 6/2012. Total . Number. of Publications. Calendar Quarter. Through . 6/30/12 postings. 1350. GWAS catalog interactive browser. Clinical Immunology. March 26, 2013. HARVARD. MEDICAL SCHOOL. Overview. Clinical characteristics and pathophysiology. Differential diagnosis. Exam and laboratory studies. Treatment strategy. Research opportunities.