PPT-Common variation, GWAS & PLINK

Jeff Barrett What are the goals of disease genetics For a given disease we would like to Predict if someone will get sick how bad it will be and what treatment will work Test hypotheses about relationships to other diseases and traits. 6 December 2012. Introduction. I. mputation describes the process of predicting genotypes that have not been directly typed in a sample of individuals:. m. issing genotypes at typed variants;. genotypes at un-typed variants that are present in an external high-density “reference panel” of phased . Presented by Karen . Xu. What you need to know. Basic genetic concepts behind GWAS. Genotyping technologies and common study designs . Statistical concepts for GWAS analysis. Replication, interpretation and follow-up of association results. IGSS 2015 Tutorial. Ben . Domingue. Gameplan. Overview. What are polygenic scores?. How are they used?. How are they created?. You create them.. Top hits. Homebrewed Genome-wide. PRSice. . Caveats, etc.. John Busby. CLAHRC West. Motivation. Schizophrenia. Hip Fracture. Outline. Background. Magnitude of geographic variation. Causes of . geographic . variation. Benchmarking. What are ACSCs?. Improved community care . Jeff Barrett. Challenges to GWAS?. Data quality control . No common, single SNP main effects (all epistasis or rare variants or …). Sample size too small to detect effects. Computational . burden. Multiple . Arts and Leisure. Athletic sports, dancing, decorative art, games, music. Basic Needs. Clothing, cooking, housing. Beliefs. Folklore, funeral rites, religious ritual. Communication & Education. Education, language. for Colorectal . Cancer. Ulrike (. Riki. ) Peters. Fred Hutchinson Cancer Research Center. University of Washington. Overview. Significance and rationale. . Current efforts on rare and less frequent variants. y = . kx. , where k ≠ 0. . The constant of variation for a direct variation . k. is the coefficient of . x.. Example of direct variation. : The time it takes to hear thunder varies directly with the distance from lightning. (As the distance from lightning increases, so does the time it takes you to hear the thunder!). 1. Attributes of Common Cause Variation. It is the variation inherent to a Process.. It cannot be reduced unless one changes the Process.. It can be considered to be the background noise present in a Process.. Guide for ParentsThis Passover story for children ages 3-6 is part of a series of three Passover readings for children and adults created by American Jewish World Service AJWS to connect the holiday o WW-ADNI Meeting, Washington DC. July 17, 2015. Andy Saykin, . Indiana University. asaykin@iupui.edu. For the Genetics Core/Working Groups. Original ADNI-2 Specific Aims. Progress Report & Impact. Inês Barroso. Joint Head of Human Genetics. Metabolic Disease Group Leader. Wellcome. Trust Sanger Institute. 1. Objectives. Why perform meta-analysis?. How? . What are the issues to consider?. What can you gain?. Clinical Immunology. March 26, 2013. HARVARD. MEDICAL SCHOOL. Overview. Clinical characteristics and pathophysiology. Differential diagnosis. Exam and laboratory studies. Treatment strategy. Research opportunities. Michelle Mello. Clinical Lead, Personalised Care Group. Professor Muir Gray. Clinical Advisor, NHS RightCare. . Awareness is the . 1. st . step to population. healthcare. improvement. If . the existence of clinical and financial variation is...