PPT-Na,K-ATPase isoform-selective cardiac glycosides

a potential anticancer drug Adriana Katz Cherniavsky Lev M Ainbinder E Tal D and Karlish SJD Weizmann Institute of Science Israel Ion channels and pumps as cancer targets. Regulation of the . Vacuolar H. +. -. ATPase. in kidney . Intercaleted. Cells during . Ischemia. N. úr. ia. M. Pastor-. Soler. , MD, PhD. Associate Professor. Renal-Electrolyte Division. Department of Medicine and . Sugar + non-sugar. In the body they are broken down by enzymes or acids into:. sugars= . glycone. / water soluble. non sugar= aglycone/ active portion. Aglycone may be an alcohol, sulfur or phenol compound.. Tara Hosseinnejad, Brenda Rattanavong, Angela Y. assa. , Wai Ying Chan. Nov. 29. th. , 2016. PHM142 Fall 2016. Instructor: Dr. Jeffrey Henderson. Outline. Introduction of beta blockers. Non-selective (β. Antiarrhythmics. ". Cardiotonic. Cardiac . glycosides. Cardiac glycosides - are substances of plant origin, which have a pronounced . cardiotonic. action and are used in the treatment of heart failure associated with myocardial dystrophy of different etiology. They increase the efficiency of the myocardium, providing the most economical and yet effective activity of the heart.. The Monarch butterfly feeds as a larva on species of milkweeds. The milkweeds contain a group of chemicals called cardiac glycosides. Cardiac glycosides are poisonous to vertebrates. The larvae store these cardiac glycosides and the later adult Monarch butterfly contains them as well. If a bird (or other vertebrate such as a mouse or frog) eats a Monarch it finds them distasteful to begin with and is later sick.. Alisa Villarreal. Lily of the Valley. Introduction. A toxin is a substance . produced by an organism that has an adverse effect on other . organisms. . Any substance can be toxic depending on the dose. . Dr. . Naser. Ashraf . Department of Basic Medical Sciences . College of Medicine . Majmaah University . Objectives . List major drug groups used in treatment of heart failure . Explain mechanism of action of digitalis and its major effects . OMICS Journals are poised in excellence by publishing high quality research. . OMICS . International follows . an Editorial Manager® System peer review process and boasts of a strong and active editorial board.. Pharmacognosy I. Mosul . University. / . College . of Pharmacy. L.A. . Dilbreen. . Barzanji. Anthraquinones. and . its glycosides. Substances of the anthraquinone type were recognized both in the free state and as glycosides. . ( . Anthraquinone. . Glycosides. ). 1. Anthracene. glycosides represent a major class of glycosides. They are abundantly found in . various . plant families, such as: . Ericaceae. , . Liliaceae. . . . 6. th. lecture/3. rd. stage/1. st. semester. A. DIGITALIS. 1. . Digitalis . purpurea. . : . (Foxglove; Purple . foxglove). Digitalis . purpurea. (. Scrophulariaceae. ). [ The word . purpurea. Here are some cardiac problem signs including chest discomfort, nausea, throat or jaw pain and more which you should never ignore. Polyadenylation: cleavage of pre-mRNA 3’ end and synthesis of poly(A) tract (. Milanesi. and Rogozin, 1998. ).. Gene contains more than one . polyA. sites are termed as alternative polyadenylation (APA), which generates distinct mRNA isoforms from the same gene (. BP405 T. PHARMACOGNOSY AND PHYTOCHEMISTRY I (Theory). UNIT-IV. Introduction to Secondary Metabolites. Glycosides. Dr. . Nisha. Sharma. Director . School of Pharmaceutical Sciences. (University . Institute of .