PPT-Circulating cancer-associated extracellular vesicles as early detection and recurrence

Yusuke Yoshioka 1 Tetsuya Nakatsura 2 Takahiro Ochiya 1 Tokyo Medical University National Cancer Center Extracellular vesicles Exosome Lipid Ceramide etc microRNA miRNA. 1- has a detection rate of 10-20% when PSA: 1-2 ng/ml. 2- has a detection rate of 81% when PSA . dt. is less than 3 months. 3- it best identifies patients with bone metastases. 4- PET/CT is indicated for pre-op staging in case of suspicious MRI. Circulating Tumor Cells (CTC). Metastasis. : the spread of cancer from its primary site to other places in the body..  Metastatic disease is the most common cause of cancer-related death in patients with solid tumors.. Nagrath. & . Sequist. et al. (2007). Journal Presentation. Brigitte Morales & Leanna Morinishi. December 8. th. , 2011. Nagrath. , S., . Sequist. , L. et al. Nature 450.7173 (2007):1235-239. Print.. Methods in Clinical Cancer Research. February 12, 2015. Effective incorporation of . biomarkers into phase II trials. There are many roles for biomarkers in Phase II trial designs.. Examples of biomarkers with pivotal role in development of new therapies. Emerging Clinical Applications. Mahmood rasheed. Hematology/oncology fellow. VCU Massey Cancer Center. Extracellular Vesicles. Heterogenous range of particles shed from virtually all cells in the human body.. Filipa Mendes. Center. for Nuclear Sciences . and. Technologies. IST, Universidade de Lisboa .  . Summer school . Development and Pre-clinical Evaluation of Radiopharmaceuticals. Molecular . and. Cell . after Stopping Endocrine Therapy at 5 . Years. The . Early Breast Cancer . Trialists. ’ Collaborative Group (EBCTCG. ). N . Engl. J Med 2017. ; 377:1836-46. ER+, 5 years. endocrine. therapy (ET). completed:. Schistosoma mansoni. in . Biomphalaria glabrata. Benson Otarigho. 1,3. ,. , . Leandro Xavier Neves. 2. , . Ananda. Lima Sanson. 2. , . Mofolusho. O. Falade. 1. , William Castro-Borges. 2. 1. Cellular Parasitology . Optimist. Department of Biochemistry, Molecular Biology and Biophysics. Institute on Biology of Aging and Metabolism. lniedern. @. umn.edu. Utility of mice in biomarker discovery. Strength . of mice. a measurable indicator . that . can . tell . us something about a person’s health or disease . state, for example, . disease (pathological) processes in the body, for example, disease stage. , . biological processes in the body (heart rate, blood pressure, temperature), . Leyen. Vu, DO. Sept. 8. th. , 2018. WSU Cougar Health Services. WSU Athletics Team Physician. Objectives. Need for objective measures for concussion. Identify characteristics of ideal serum biomarkers for concussion. The Need. HD is a dominantly inherited neurodegenerative disorder caused by a mutant Huntington gene. Diagnosis of HD is determined by genetic testing but clinical stage and age of onset must be defined by its symptoms. Diverse disease landmarks precede the onset and define the premanifest stage (P-HD). The plasma neurofilament light chain (. Carolyn Yanavich, . Antônio Pacheco, Sandra . W Cardoso, Estevão Portela, Ursula . B Chaves, Ricardo Santos, . Michelle Morata, . Valdilea . G Veloso, Beatriz . Grinsztejn, . Hugo Perazzo. National Institute of . March 7, 2018. Walter Park, MD, MS. On behalf of PCDC Investigators. Pancreatic Cancer Detection Consortium (PCDC). Pancreatic Cancer Detection Consortium. Recalcitrant Cancer Research Act of 2012: Scientific frameworks for cancers with 5-year OS...