PPT-Circulating Tumor Cells

Circulating Tumor Cells CTC Metastasis the spread of cancer from its primary site to other places in the body  Metastatic disease is the most common cause of cancerrelated death in patients with solid tumors. Sunitha Nagrath et al.. http://www.nibib.nih.gov/news-events/newsroom/circulating-tumor-cells-captured-last. Presentation by: . Keara. . Darragh. , Matthew . Faw. , and Will Plautz. Overview of . Metastasis. Colin Reisterer and Nick Swenson. S. . Maheswaran. et al. . The New England Journal of Medicine. . 2007. http://www.all-cancer-treatments.com/types-of-lung-cancer.html. Clinical background: Non-small cell lung cancer (NSCLC). Nagrath. & . Sequist. et al. (2007). Journal Presentation. Brigitte Morales & Leanna Morinishi. December 8. th. , 2011. Nagrath. , S., . Sequist. , L. et al. Nature 450.7173 (2007):1235-239. Print.. By: . Weigang. . wang. , . sumanta. . goswami. , Erik . sahai. , . jeffrey. . b. . wyckoff. , Jeffrey E. . Segall. and John S. . Condeelis. Presented By: Lana . Awad. and Sebastian Lukjan. Motivation of research, why they did what they did…. c. aught in the act of invading: Their strategy for enhanced cell motility” . By Xinqi Li and Megan Roytman. Weigang . Wang, . Sumanta . Goswami, . Erik . Sahai, . Jeffrey B. . Wyckoff, . Jeffrey E. . Arshed A. Quyyumi, MD . Professor of Medicine . Emory Clinical Cardiovascular Research Institute (ECCRI). Emory University School of Medicine. Atlanta, GA. Grant support: . National Institutes of Health, . SUPERVISOR. 趙大中醫師. Breast Cancer. The most prevalent cancer in female. Mortality 4. th. in Taiwan. Treatment of Breast Cancer. Breast Cancer. When to change regimen?. Unacceptable toxicity. By: . Weigang. . wang. , . sumanta. . goswami. , Erik . sahai. , . jeffrey. . b. . wyckoff. , Jeffrey E. . Segall. and John S. . Condeelis. Presented By: Lana . Awad. and Sebastian Lukjan. Motivation of research, why they did what they did…. At diagnosis 80% of patients will present with metastasis.. Only 20% of these cases are clinically detectable.. Current imaging modalities are expensive and only detect established secondary tumors.. Do Now. Why did Steve Jobs’ tumor metastasize to his liver and lung but not other organs?. Is it primary or secondary?. Primary tumor of lymph node (lymphoma). Secondary tumor (melanoma) in lymph node. Normal parathyroid. Incidental cyst. (not important). capsule. The neoplasm. Normal parathyroid. Parathyroid adenoma. Tumor behavior is . much more important . than morphology. Tumor invasion in the capsule. The market for circulating tumour cells is primarily driven by the rising understanding of
their diagnostic and clinical utility, which has prompted an increase in circulating tumour cell research in
an effort to develop efficient diagnostic tools. Breast Cancer. The most prevalent cancer in female. Mortality 4. th. in Taiwan. Treatment of Breast Cancer. Breast Cancer. When to change regimen?. Unacceptable toxicity. Progression disease. Current Tools for Follow-up. Intervista a Federico . Cappuzzo. Background:. Programmed death-ligand 1 (PD-L1) expression on tumor cells (TC) or tumor-infiltrating immune cells (IC) is associated with OS, PFS and ORR in pts with advanced NSCLC treated with atezolizumab (anti-PDL1, MPDL3280A; Spigel et al, Spira et al, ASCO 2015), indicating that PD-L1 expression on both TC and IC is important for anti-tumor immunity. However, these 2 distinct expression patterns suggest the existence of previously unidentified NSCLC subtypes with distinct immunologic profiles. .