PPT-“Tumor cells

c aught in the act of invading Their strategy for enhanced cell motility By Xinqi Li and Megan Roytman Weigang Wang Sumanta Goswami Erik Sahai Jeffrey B Wyckoff Jeffrey E . By: . Weigang. . wang. , . sumanta. . goswami. , Erik . sahai. , . jeffrey. . b. . wyckoff. , Jeffrey E. . Segall. and John S. . Condeelis. Presented By: Lana . Awad. and Sebastian Lukjan. Motivation of research, why they did what they did…. Intervista a Federico . Cappuzzo. Background:. Programmed death-ligand 1 (PD-L1) expression on tumor cells (TC) or tumor-infiltrating immune cells (IC) is associated with OS, PFS and ORR in pts with advanced NSCLC treated with atezolizumab (anti-PDL1, MPDL3280A; Spigel et al, Spira et al, ASCO 2015), indicating that PD-L1 expression on both TC and IC is important for anti-tumor immunity. However, these 2 distinct expression patterns suggest the existence of previously unidentified NSCLC subtypes with distinct immunologic profiles. . By: . Weigang. . wang. , . sumanta. . goswami. , Erik . sahai. , . jeffrey. . b. . wyckoff. , Jeffrey E. . Segall. and John S. . Condeelis. Presented By: Lana . Awad. and Sebastian Lukjan. Motivation of research, why they did what they did…. Proposed an efficient exosome-based tumor antigens-adjuvant co-delivery system:. Genetically engineered tumor cell-derived exosomes: . Endogenous tumor antigens. Immunostimulatory. . CpG. DNA. Source cells (for exosome): murine melanoma B16BL6. And. Dynamical . . Modeling Of Tumor Decay. Amy W. Daali. Ph.D. . . Defense. Spring 2015. Electrical . and Computer Engineering Department . University of Texas at San Antonio.  . PCA based Algorithm for Longitudinal Brain Tumor Stage Classification & Dynamical Modeling of Tumor Decay . At diagnosis 80% of patients will present with metastasis.. Only 20% of these cases are clinically detectable.. Current imaging modalities are expensive and only detect established secondary tumors.. Do Now. Why did Steve Jobs’ tumor metastasize to his liver and lung but not other organs?. Is it primary or secondary?. Primary tumor of lymph node (lymphoma). Secondary tumor (melanoma) in lymph node. LEC.4. Examples of tumor suppressor genes:. 1. RB gene:. This is the . first discovered suppressor gene. , . loss of normal RB gene was discovered initially in Retinoblastoma, but recently proved it lost in many tumors (breast cancer, bladder & lung cancer, osteosarcoma).. Normal parathyroid. Incidental cyst. (not important). capsule. The neoplasm. Normal parathyroid. Parathyroid adenoma. Tumor behavior is . much more important . than morphology. Tumor invasion in the capsule. Séminaire. des . doctorants. William . Weens. BANG, . Inria. November. . 15th . 2011. Outline. Cancer. Systems Biology. Mathematical description. Application to liver tumor. Conclusion. Definition. PROFESSOR, DEPT OF PATHOLOGY. SKHMC. The British oncologist . Sir Rupert Willis definition : . "A neoplasm is an abnormal mass of tissue, the growth of which exceeds and is uncoordinated with that of the normal tissues and persists in the same excessive manner after cessation of the stimuli which evoked the change." . Glioblastoma. Maria Gubbiotti, MD/PhD Candidate. Jefferson Medical College. The burden of brain cancer. <1% chance of developing malignant brain cancer during one’s lifetime. In 2019:. ~23,820 malignant tumors of the brain and spinal cord will be diagnosed. Neoplasia. is a process of “new growth” in which normal cells undergo irreversible genetic changes, which render them unresponsive to ordinary controls on growth exerted from within the “transformed” cell or by surrounding “normal” cells.. Intervista a Federico . Cappuzzo. Background:. Programmed death-ligand 1 (PD-L1) expression on tumor cells (TC) or tumor-infiltrating immune cells (IC) is associated with OS, PFS and ORR in pts with advanced NSCLC treated with atezolizumab (anti-PDL1, MPDL3280A; Spigel et al, Spira et al, ASCO 2015), indicating that PD-L1 expression on both TC and IC is important for anti-tumor immunity. However, these 2 distinct expression patterns suggest the existence of previously unidentified NSCLC subtypes with distinct immunologic profiles. .