PPT-“Tumor cells

c aught in the act of invading Their strategy for enhanced cell motility By Xinqi Li and Megan Roytman Weigang Wang Sumanta Goswami Erik Sahai Jeffrey B Wyckoff Jeffrey E . Sam Kupfer and Joseph Ahmad. Background/Outline. Cancer is a group of diseases in which abnormal cells divide uncontrollably, forming tumors that interrupt the normal functioning of nearby cells and organs. Circulating Tumor Cells (CTC). Metastasis. : the spread of cancer from its primary site to other places in the body..  Metastatic disease is the most common cause of cancer-related death in patients with solid tumors.. Nagrath. & . Sequist. et al. (2007). Journal Presentation. Brigitte Morales & Leanna Morinishi. December 8. th. , 2011. Nagrath. , S., . Sequist. , L. et al. Nature 450.7173 (2007):1235-239. Print.. Recurrence and Metastasis: A Major Factor in Cancer-related Deaths. Cancer is the second leading cause of death in the United States. 1. Despite advances in cancer treatment, many patients develop:. Hemangiopericytoma. Spectrum in Brain, Head & Neck, and Spine—Pathological Correlations. Kwofie. M. 1. , . Moritani. T. 1. , . Vijapura. C. 1. , . Kademian. J. 1. , Kirby . P. 2. 1: Department of Diagnostic Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA. By: . Weigang. . wang. , . sumanta. . goswami. , Erik . sahai. , . jeffrey. . b. . wyckoff. , Jeffrey E. . Segall. and John S. . Condeelis. Presented By: Lana . Awad. and Sebastian Lukjan. Motivation of research, why they did what they did…. At diagnosis 80% of patients will present with metastasis.. Only 20% of these cases are clinically detectable.. Current imaging modalities are expensive and only detect established secondary tumors.. Do Now. Why did Steve Jobs’ tumor metastasize to his liver and lung but not other organs?. Is it primary or secondary?. Primary tumor of lymph node (lymphoma). Secondary tumor (melanoma) in lymph node. LEC.4. Examples of tumor suppressor genes:. 1. RB gene:. This is the . first discovered suppressor gene. , . loss of normal RB gene was discovered initially in Retinoblastoma, but recently proved it lost in many tumors (breast cancer, bladder & lung cancer, osteosarcoma)..  . Project . Promoter: University of Tartu. Project . Leader: . Tambet Teesalu . PhD, Visiting Professor.  . Project Partner: University of Bergen. Research Group Leader: . Rolf Bjerkvig. , PhD, Professor. What do we know about childhood brain tumors? What do we know about childhood brain tumors? Brain tumors represent about 25% of all childhood cancer diagnoses. patients under 20 years of age ea under Neoplasia. is a process of “new growth” in which normal cells undergo irreversible genetic changes, which render them unresponsive to ordinary controls on growth exerted from within the “transformed” cell or by surrounding “normal” cells.. Intervista a Federico . Cappuzzo. Background:. Programmed death-ligand 1 (PD-L1) expression on tumor cells (TC) or tumor-infiltrating immune cells (IC) is associated with OS, PFS and ORR in pts with advanced NSCLC treated with atezolizumab (anti-PDL1, MPDL3280A; Spigel et al, Spira et al, ASCO 2015), indicating that PD-L1 expression on both TC and IC is important for anti-tumor immunity. However, these 2 distinct expression patterns suggest the existence of previously unidentified NSCLC subtypes with distinct immunologic profiles. .