Do Now Why did Steve Jobs tumor metastasize to his liver and lung but not other organs Is it primary or secondary Primary tumor of lymph node lymphoma Secondary tumor melanoma in lymph node ID: 919826
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Slide1
Cancer
Lesson 4.3
How do tumor cells find a new home?
Slide2Do Now
Why did Steve Jobs’ tumor metastasize to his liver and lung but not other organs?
Slide3Is it primary or secondary?
Primary tumor of lymph node (lymphoma)
Secondary tumor (melanoma) in lymph node
Slide4Important terms
A
primary lung tumor is a tumor in lung cells.A metastatic lung tumor is a lung tumor that can metastasize to another organ.
A secondary lung tumor has originated in another organ and metastasized to lung.
Slide5What do cancer cells look for in a new home?
Primary tumor in the skin
Metastatic (secondary)
tumorsMelanoma
Slide6Some secondary organs are chosen because they are close to
primary organ
PP
Primary cancer in cecum
Metastatic colon
cancer in liver
Portal vein
Tumors in colon
Tumors in liver
Slide7Secondary organs secrete signals cancer cells recognize!
Serotonin
Slide8Seed and fertile soil hypothesis
Metastatic cells travel
in the bloodstream ‘highway’:Do they settle at an appropriate exit (secondary organs)? ORDo they get off at multiple exits but only grow in one destination?
Slide9Seed and fertile soil
Soil
Seeds
Lungs
Liver
Brain
Slide10Activity
Find the ‘Fertile Soil’: Secondary tumor sites
Slide11Activity
Cell line
Adhesion to liver
Growth on liverInvasion ofliver
COL-2-JCK
5/5
5/5
5/5
Co-3
5/5
5/5
5/5
Co-6
5/5
0/5
0/5
Slide12Which Organs are ‘most
fertile’?
PrimaryTumor
BrainLiverLungsBoneBreast10253035Melanoma203530
15
Prostate
20
20
25
35
Colon
5
10
75
10
Pancreas
5
20
70
5
Slide13What happens when cancer cells metastasize to the liver?
Primary cancer
in cecum
Metastatic colon cancer in liver
Yellowing complexion-Jaundice
Slide14What happens when the cancer cells metastasize to the lung?
Slide15What happens when the cancer cells metastasize to the bone?
Slide16What happens when cancer cells metastasize to the brain?
Slide17Wrap Up: The real picture of metastasis?
Soil
Lungs
LiverBrain
Bone
Spleen
Kidney
We most are more likely to find metastases in vital organs -they have the most obvious symptoms
Slide18Homework
Read an article
about a host factor that promotes chemotherapy resistance among secondary tumors.