PPT-Biomarkers redux? Laura J. Niedernhofer, M.D., Ph.D.

Optimist Department of Biochemistry Molecular Biology and Biophysics Institute on Biology of Aging and Metabolism lniedern umnedu Utility of mice in biomarker discovery Strength of mice. Leslie M Shaw & John Q . Trojanowski. Magdalena Korecka. Michal Figurski. Teresa . Waligorska. Magdalena Brylska. Leona Fields. Nirali. Shah. Biomarker Core Aims for ADNI 3. Continue to collect, store, curate and track all . Little House on the Prairie. Laura Ingalls Wilder was born in 1867 in a log cabin. There were no roads and no people but plenty of wild animals such as wolves, bears, wild cats, muskrats, mink, otters, foxes and deer.. A Rigorous Discovery-Validation Path Was Taken. 2. Discovery Study. 340 proteins analyzed . (. including KIM-1, urine NGAL, plasma NGAL, . Cystatin. -C, IL-18, pi-GST, and L-FABP). Validation Study. Primary Endpoint: moderate to severe AKI (KDIGO stage 2-3) within 12 hours of . FAINELLI . Manon. BOGÓ . Ákos. . Szakács . Júlia . M.D. . . Department of Pathophysiology. Numbers…. Cardiovascular diseases . The most frequent cause of death. 7.5 millions of death/ year. Important concerns in developed countries. A Story About Sleep and Dreams. Laura and Amy are having a sleepover. They are very excited because the next day they are going to be in a dance recital.. Laura’s mom tells the girls that it is very important for them to get a good night sleep because they will be getting up early. . W. ilder. Naomy. Birth. Laura was born February. . 10,1867.. She was born in the woods of Wisconsin .. Her parents are Charles and Caroline.. education. Laura went to school as a little kid at Walnut Grove. . Mike Chapman. University of Cambridge Department of Haematology. Novel agents have improved survival. What is a biomarker?. “A characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention”. and Their Relationship to Health. Mark Pettus MD. Medical Director Functional Formularies. Director Medical Education, Wellness and Population Health. Berkshire . H. ealth Systems. Learning Objectives. SSG Anthony Barton. HRO-AGR. Agenda. Types of Retired Pay Systems. Impact of REDUX on Retired Pay. Career Status Bonus. CSB Election Process. Types of Retired Pay Systems. Final Base Pay . = joined prior to 8 Sep 80. Paul Dagum, MD PhD. Mindstrong Health. National Alliance in Mental Health. Washington, CD. June 30, 2017 . CHALLENGES IN MENTAL HEALTH. LACK OF MEASUREMENT. Episodic, subjective measures in laboratory environments lack sensitivity — may fail to detect clinical change . a measurable indicator . that . can . tell . us something about a person’s health or disease . state, for example, . disease (pathological) processes in the body, for example, disease stage. , . biological processes in the body (heart rate, blood pressure, temperature), . Presented by: . Dr. Puneet Opal . Dr. Hayley McLoughlin. A Virtual Event. March 17-19, 2022. DISCLAIMER. 2022 AAC. A Virtual Event. March 17-19. PRESENTER DISCLOSURES. Dr. Puneet Opal (Northwestern University). Routing (react-router, connected-react-router, react-helmet). Forms (redux-forms, classes). Fetch API (isomorphic-fetch, promise, . async. /await, file upload). Web project assignment (assignment, prototype, features, REST API). Nfl. =neurofilament light; PDGFR. . =. platelet-derived growth factor receptor beta. ; . PET=positron emission tomography; p-tau=phosphorylated tau; RT-. QuIC. =real-time quaking-induced conversion; SNAP-25=.