PPT-VASCULITIS…. Is associated with endothelial damage occurring as a direct result of

Causes Systemic viral diseases such as equine viral arteritis 2 equine infectious anemia 3African horse sickness 4malignant catarrhal fever 5 bovine ephemeral fever 6bovine virus diarrhea . Švehlíková. G.. Department . of. . Ophthalmology. LF UPJS v Košiciach. Prednosta: prof. MUDr. Juhás T., DrSc.. Anatomy. . of. . the. . cornea. Epitelium. Stroma. . Endotelium. Clinical. failure. First and Presenting author: Jeewan S. Titiyal. Co-authors: Tarun Arora, Manpreet Kaur, Tushar Agarwal. Affiliation: RP Centre, AIIMS, New Delhi, India. None of the authors of this poster have any financial interests. By: Dr. Donna Braham. Objectives. Classify Vasculitis. Know when to consider Vasculitis. Rule out mimickers of Vasculitis. Diagnose cutaneous small vessel vasculitis – In . particular Henoch–. Schönlein. Takayasu’s arteritis, giant cell arteritis and primary CNS angiitis all have granulomatous angiitis. Takayasu’s arteritis:. This affects the aortic arch, main arterial trunks and descending aorta including the carotid and subclavian arteries. The clinical features of the various . vasculitides. are protean and largely depend on the vascular bed affected (e.g., CNS vs. heart vs. small bowel). . Besides the findings referable to the specific tissues involved, the clinical manifestations typically include constitutional signs and symptoms such as fever, . aortitis. ?. Emily Grodinsky. 11.5.2020. Categorizing vessels by size. More on primary vasculitidities. Even diseases like GCA/. Takayasu. arteritis have significant effects from the smaller vessels (e.g., ophthalmic or retinal arteries in GCA leading to significant morbidity, despite not being “large vessels”). Signs and symptoms:. 1- . local. :. according. to the involved tissue. 2- . systemic. :(fever, . myalgia. , . arthralgias. , and malaise). Pathogenesis . 1- immune-mediated inflammation. . 2- . infectious pathogens. Phagocytes. Phagocytosis. Phagocytes. engulf the pathogens and digest them.. Lymphocytes. Antibody. production. Specific. antibodies destroy the pathogen. This takes time so an infection can occur. If a person is infected again by the same pathogen, the lymphocytes make antibodies much faster.. Cells and . Blood Cells/Factors. Intercellular/Cell-Surface Elements. Selective alteration/dysregulation . of junctional proteins (. Claudins. , . . Occludin. , JAM, ...). Cell Adhesion proteins (E-Selectin, . CABM FIBMS. Internist & Rheumatologist. Large Vessel Vasculitis . Takayasu arteritis. Mikito Takayasu (. 1860.  . - 1938)  . Japanese ophthalmologist. CLINICAL FEATURES . . Diagnosis. . By angiography, which reveals Coarctation, occlusion &aneurysmal dilatation. . Vasculopathy. Fibrinoid deposition, thrombosis with limited to no inflammation.. Infiltration of vessel wall by inflammatory cells with otherwise minimal alteration.. Leukocytoclasis. of tissue infiltrate with minimal alteration of vessel, that is, swelling only, absence of fibrinoid. PRESENTER- Dr. B. PRADEEP.. CHAIR PERSON- Dr. T. SMRUTHI.. Vasculitis are group of disorders characterized by . immunoinflammatory. injury to vessel wall . leading to aneurysm, bleeding, stenosis, occlusion, thrombosis, embolism and ischemia. . clastic. vasculitis. . The . majority of cases occur as sequelae to strangles. However, Cases also occur following. . immunization against . S. . equi. . and as sequelae to infection with other streptococci.. aortitis. ?. Emily Grodinsky. 11.5.2020. Categorizing vessels by size. More on primary vasculitidities. Even diseases like GCA/. Takayasu. arteritis have significant effects from the smaller vessels (e.g., ophthalmic or retinal arteries in GCA...