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Bone-Targeted Therapy  in the Adjuvant Breast Cancer Setting Bone-Targeted Therapy  in the Adjuvant Breast Cancer Setting

Bone-Targeted Therapy in the Adjuvant Breast Cancer Setting - PowerPoint Presentation

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Uploaded On 2018-11-05

Bone-Targeted Therapy in the Adjuvant Breast Cancer Setting - PPT Presentation

CancerTreatmentInduced Bone Loss CTIBL Clodronate and Bone Mineral Density Hip Bone Mineral Density Substudy ABCSG12 Effect of Zoledronic Acid Percent Change Lumbar Spine Denosumab for CTIBL ID: 716297

bone cancer breast adjuvant cancer bone adjuvant breast abcsg references denosumab setting treatment spine ctibl therapy clinical mineral density

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Presentation Transcript

Slide1

Bone-Targeted Therapy in the Adjuvant Breast Cancer SettingSlide2

Cancer-Treatment-Induced Bone Loss (CTIBL)Slide3

Clodronate and Bone Mineral Density (Hip)Slide4

Bone Mineral Density Substudy --ABCSG-12: Effect of Zoledronic AcidPercent Change, Lumbar SpineSlide5

Denosumab for CTIBL (Lumbar Spine)Slide6

Metastatic Niches in Bone MarrowSlide7

Differential Impact of Menopausal StatusSlide8

The "Low Estrogen" HypothesisSlide9

Adjuvant Bisphosphonate Treatment Breast Cancer Recurrence-Postmenopause* Slide10

Conclusions: EBCTCG Meta-AnalysisSlide11

ABCSG-12 Trial DesignSlide12

Adjuvant Denosumab in Breast Cancer (ABCSG-18, Phase 3) Primary Endpoint, First Clinical Fracture Slide13

Adjuvant Denosumab in Breast Cancer (ABCSG-18 Subgroup) Tumor Size > 2 cmSlide14

Bone-Targeting Therapy in Adjuvant Breast Cancer Setting Clinical ConclusionsSlide15

Slide16

ReferencesSlide17

References (cont)Slide18

References (cont)Slide19

Abbreviations