PPT-Endocrine therapy in breast cancer

DrMina Tajvidi Radiation oncologist Endocrine therapy in breast cancer Endocrine therapy for hormone receptor positive early stage breast cancer in premenopausal women. DR. A. AKHATOR FWACS, FICS. SENIOR LECTURER DELSU . CONSULTANT SURGEON DELSUTH. PRE-TEST. Breast cancer is the most common cancer in women in Nigeria . Breast cancer is the most common cause of cancer related deaths. HR Advanced Breast Cancer. Introduction. Restaging at Relapse vs De Novo Metastatic Disease. Visceral Crisis. Personalizing Endocrine Therapy. Endocrine Therapy Landscape. FIRST Trial. Fulvestrant vs Anastrozole. Christy A Russell, MD. Keck School of Medicine. University of Southern California. Hazard Rate of Relapse. According to Tumor Subtype and Year of Diagnosis. British Columbia Population-Based Data. 1986-1992. Targeting endocrine-resistance pathways in breast cancer Clara Natoli, Chieti Endocrine responsive breast cancer Luminal A High expression of ER & ER-related genes Lower BRCA2 is a tumor suppressor gene responsible for DNA repair . BRCA2 was discovered in breast cancer tumors of patients without BRCA1 mutations. Mice knockouts discovered that BRCA2 is directly involved in double strand break repair. RISK FACTORS FOR BREAST CANCER. Family . Hx. .: first- . and second-degree relatives with breast cancer and their age at diagnosis. .. RISK FACTORS FOR BREAST . CANCER . (. cont.). . Hormonal . Risk Factors. for . communicating, controlling and . coordinating . the body’s work. Endocrine System. Control . system . that . works along with the nervous . system to regulate body functions and maintain homeostasis.. hormones: chemicals released into the bloodstream by endocrine glands. Pituitary gland: gland located in the brain that secretes human growth hormone and influences all other hormone-secreting glands (also known as the master gland). Breast Cancer in the US . Breast Cancer is estimated to affect . over 230,000 . women . annually in the US. Based on SEER Database rates from 2009-2011, the . cumulative lifetime risk. of an average woman in the general US population is 12.3%. L. MEYSKENS, D. (32, 33), and hormonal (42, 46, (60, 78). 57, 66, cancer in is less Klinefelter'n syndrome with male authors measured et al. the formation ofestrone results rerrmin in males been repo therapy. . is. to be . used. in post-. menopausal. . breast. . cancer. woman. Antonino . Grassadonia. Università «G. D’Annunzio» – Chieti-Pescara. Neoadjuvant . Systemic Therapy of . Primary . Azeez Farooki, MD. Attending Physician, Clinical Member. Memorial Sloan Kettering Cancer Center. New York, NY. Objectives. Elucidate the problem of aromatase inhibitor induced bone loss and increased risk of fractures in breast cancer. . Breast Cancer | . Epidemiology- Australia. Australian Institute of Health and Welfare 2014. ACIM (Australian Cancer Incidence and Mortality) Books. Canberra. AIHW. Overall is the third leading cause of cancer. The nervous system and endocrine system controls different types of activities in the body. . They are jointly responsible for the functioning of all the different organs and systems, this is known as coordination.