Institute Dr. Schrader - PDF document

1 Institute Dr. Schrader Institute Dr. Schrader MathiasRohrNing,ChengYanzhang,AndreasSchraderProtectionEuropeMentionableRemarks 2 Institute Dr. Schrader TestMethodTesting:Quantifyingvalue,protectionlevelagainstReaction.(protectedskin)(unprotectedskin) ProtectionFactor)ratioEnergiesareprovokeReactionProductapplication. Institute Dr. Schrader (protectedskin)(unprotectedskin) thatproducesfirstperceptiblebordersovermostexposureafterexposurelinkedTestMethod 3 Institute Dr. Schrader TestingWhat StandardProducts Statistics Energy ProductApplication LightSteps Excitation Institute Dr. Schrader –ConditionsProductApplicationIrradiationEnergyHomogeneityReadingStandardsLabel–SPFSubjects–ConditionsTestMethod 4 Institute Dr. Schrader StableConstantTemperature:C–26 Institute Dr. Schrader Lab 5 Institute Dr. Schrader 5152035 SprayMilkMilk RoomTemperature Institute Dr. Schrader 4060 SPFFMilk RoomTemperature 6 Institute Dr. Schrader –ConditionsProductApplicationIrradiationEnergyHomogeneityReadingStandardsLabel–SPFSubjectsProductApplicationProductApplication Institute Dr. Schrader ProductApplicationProductAmount:2.00mg/cmmg/cmProductDistribution:20–50s:min.Waiting:15–30TestArea:Backdistance 7 Institute Dr. Schrader ProductApplication:approx.DropSyringePipetteFingerstallhomogenousdistributionslightpreasure ProductApplication Institute Dr. Schrader ProductApplicationAmountProduct 0.00.51.01.52.02.5 0.4610.511.54.1313.3 Product Product ProductProduct[mg/cmSPFPublicationDGKWorkingGroup 8 Institute Dr. Schrader 0.00.51.01.52.02.5 Product Product Product Monoexponential         DecayAmountProduct[mg/cm95%[%]ProductApplicationAmountProduct Institute Dr. Schrader –ConditionsProductApplicationIrradiationEnergyHomogeneityReadingStandardsLabel–SPFSubjectsIrradiationIrradiationEnergyHomogeneity 9 Institute Dr. Schrader IrradiationSimulator:XenonSimulatorHomogenousenergydistributionStabileenergyoverBalance:RatioUVAUVA–320 UVA–400 UVA–340 UVA–400 Institute Dr. Schrader SpectralNopainduringirradiationAdjustmentRCEEStandardRCEERelative–Cumulative–Erythemal–EffectivenessMaximalSpectralEnergyof120mW/cm 10 Institute Dr. Schrader 30040050060070080090010000.01100 UG11Wavelength[nm]Intensity[counts/s] LimitsExcitation Institute Dr. Schrader 30040050060070080090010000.01100 Wavelength[nm]Intensity[counts/s]Excitation 11 Institute Dr. Schrader Excitation 2803003203403603804004200.01100 WG320Wavelength[nm]Intensity[counts/s] 100 ErythemalEffectiveness[%] Institute Dr. Schrader COLIPARCEELowerLimitRCEEUpperLimit46.067.080.091.086.595.090.597.093.599.0–400RCEEValues 12 Institute Dr. Schrader 280300320340360380400420100 Simulator[%]Wavelength[nm] RCEEValues 1994 Institute Dr. Schrader RCEELowerLimitRCEEUpperLimit2.08.049.065.085.090.0 COLIPARCEELowerLimitRCEEUpperLimit46.067.080.091.086.595.090.597.093.599.0 SpectralDefinitionRCEEValues 13 Institute Dr. Schrader 280300320340360380400420100 Simulator[%]Wavelength[nm] RCEEValues 1994 2006 Institute Dr. Schrader ExternalCertification 14 Institute Dr. Schrader –ConditionsProductApplicationIrradiationEnergyHomogeneityReadingStandardsLabel–SPFSubjectsReadingReading Institute Dr. Schrader ReadingReadinghastobecarriedoutafterirradiationandMEDpReadinghastobecarriedoutdaythatproducesfirstperceptiblebordersovermostexposureafterexposureProductapplicationandMEDreadinghastobecarriedfrom2differenttechnicians 15 Institute Dr. Schrader UVBErythema 125%=80% Institute Dr. Schrader IncreasingIncrements12%or25%geometricprogressionForSPFhavetobeused!areacceptedaswell 16 Institute Dr. Schrader Increasing406080100120140160 SPFIncrement SPF SPF SPF Institute Dr. Schrader 10SPF20SPF30SPF163147781225386310203050816244061319325101526 10SPF20SPF30SPF132538631122345610203050918274581624407142136Increasingoder12% 17 Institute Dr. Schrader Increasingoder25%406080100120140160 SPFIncrement SPF SPF SPF Institute Dr. Schrader Inkrementsor25%geometricprogressionForSPFhavetobeused!TestingonlycanproducedefeniteSPFValuesIncreasingAbsorptionarenotlinkedlinear! 18 Institute Dr. Schrader Transmission 0102030405060708090100100 SPFTransmission Transmission 100 Absorption Institute Dr. Schrader 05101520253035404550556065 80859095100 Absorption[%]Transmission 13.017.6 25.997.1 19 Institute Dr. Schrader –ConditionsProductApplicationIrradiationEnergyHomogeneityReadingStandardsLabel–SPFSubjectsStandardsLabel–SPFStandards Institute Dr. Schrader StandardProducts StandardProducts2006ISOP216.6P316.2P75.1–5.9)–4.8) 20 Institute Dr. Schrader isnotdefinedbytheIMortheISOCommissionRecommendationSeptember Institute Dr. Schrader –9.9)–14.9)–19.9)–24.9)–29.9)–49.9)–59.9)VeryHigh 21 Institute Dr. Schrader –ConditionsProductApplicationIrradiationEnergyHomogeneityReadingStandardsLabel–SPFSubjectsSubjects Institute Dr. Schrader PhototypeI,(Fitzpatrick)TypI:alwayseasily,nevertansTypII:alwayseasily,tansTypIII:moderately,tansgraduallyITAITAverylightITAvonbis55lightITAvonbis41intermediateITA[arctg((L*(ITATypologyPhototype 22 Institute Dr. Schrader reactionbathlastweeksHomogenouscolourtestareabetweenSkapulaundwaist)monthsbreaklasttesttanningExclusionCriteriaageconsentPregnantlactatingwomenPhotosensitisingmedicationAntiinflammatorymedicationDermatologicalproblemsAccustomedtanning Institute Dr. Schrader Type Type TypeCorrelationITAEuropeITA[arctg((L* 2530354045505560657075 ITA°MEDu[mJ/cm 23 Institute Dr. Schrader CorrelationITAEurope 2530354045505560657075 ITA°MEDu[mJ/cm 2530354045505560657075 MEDu[mJ/cm perITA Linear(y=0.400x=0.971) Institute Dr. Schrader CorrelationITA 2530354045505560657075 ITA°MEDu[mJ/cm 2530354045505560657075 ITA°MEDu[mJ/cm Linear(y=0.643x=0.641) 24 Institute Dr. Schrader 2530354045505560657075 MEDu[mJ/cm perITA Fit=0.971)CorrelationITAEurope Linear(y=0.643x=0.641) Institute Dr. Schrader DifferentdistributionPhototypesDifferentcorrelationPhototypeandresultingDifferentcorrelationPhototypeandresultingstudieshaveorderdifferencesmightdifferencesdeterminationresultsEuropecompared!–Europe 25 Institute Dr. Schrader SPF SpectralLimits TotalEnergies Application StandardProducts Reading Increment Institute Dr. Schrader ObrigadoparasuaatençãoyouforyourattentionMercidevotreattentionGraciasporsuatenciónVielenDankIhreAufmerksamkeit Headquarters 26 Institute Dr. Schrader Max-Planck-Str. 6D-37603 HolzmindenPhone: +49 55 31 93 13 0Fax: +49 55 31 93 13 500E-Mail: info@schrader-institute.deInternet: www.schrader-institute.de Institute Dr. Schrader