PPT-Multi-Compartment Pharmacokinetics

Chapters 19 and 20 http wwwboomerorg cp4 One versus Two Compartment Rapid Equilibrium versus Slower Equilibrium http wwwboomerorg cp4c19c1901html MultiCompartment Pharmacokinetic Model. . . Compartment Syndrome. Definition. Elevated tissue pressure within a closed fascial space. Reduces tissue perfusion - ischemia. Results in cell death - necrosis. True Orthopaedic Emergency. Acute Compartment Syndrome Of The Upper Arm. Most illustrations from:. Thieme Atlas of Anatomy: Musculoskeletal System. M Schuenke, et al, 2006.. Anatomy: A Regional Atlas of the Human Body. Carmine Clemente, 4th edition.. Limb Development. Lower limb develops in an anterolateral position at the level of the L2 to S3 trunk segments. A . retrospective case series review. Dr. . Ehab.F. . . Girgis. &. Dr. Daniel S.Z.M. Boctor. TAKE HOME MESSAGES. 1. THINK ABOUT SOFT TISSUE INJURY. 2. COMPARTMENT SYNDROME CAN BE. SPONTANEOUS. 3. COMPARTMENT SYNDROME CAN BE SPONTANEOUS & UPPER ARM . protein trafficking . Lecture . 3: . Cell . Biology. . interactive. .  media  ”video” or ”. interactive. ”. 1. Cell biology 2014 . (Revised 23/1 -14) Note handout concerning endosomes/lysosomes. Most illustrations from:. Thieme Atlas of Anatomy: Musculoskeletal System. M Schuenke, et al, 2006.. Anatomy: A Regional Atlas of the Human Body. Carmine Clemente, 4th edition.. Limb Development. Lower limb develops in an anterolateral position at the level of the L2 to S3 trunk segments. Sathish Rajasekaran, MD, Clinical Assistant Professor, Division of PM&R, University of Alberta. None . Disclosures. Introduction. Anatomy. Pathophysiology. History and Physical Exam. Diagnostic Evaluation. &. COMPARTMENT SYNDROME. CRUSH INJURIES – Are a particular type of blunt trauma that applies force which stretches tissues beyond their normal tolerances. . (. emsworld. definition). COMPARTMENT SYNDROME – Is a complication of crush injuries where internal swelling creates pressure within the compartment which may cause tissue damage and inhibit proper perfusion. . Professor, Dept. of Orthopedic Surgery, . Univ. of . Minnesota. Chief, Department of Orthopaedic Surgery . Hennepin County Medical . Center. April 2016. Disclosure Information. Andrew H. Schmidt, M.D.. Jessica Tagerman, . PharmD. , . RPh. Pharmacokinetics & pharmacodynamics. Pharmacodynamics: What the drug does to the body. Pharmacokinetics: What the body does to the drug. pharmacodynamics. “What the drug does to the body”. BW733. October 1, 2013. Pharmacokinetics . WebQuest. 1. http://. www.speedlighter.ca/2011/12/25/why-i-shoot-stills/courtney-craig-photo-by-michael-willems. /. Overview. Introduction. Absorption. IV, . A . retrospective case series review. Dr. . Ehab.F. . . Girgis. &. Dr. Daniel S.Z.M. Boctor. TAKE HOME MESSAGES. 1. THINK ABOUT SOFT TISSUE INJURY. 2. COMPARTMENT SYNDROME CAN BE. SPONTANEOUS. 3. COMPARTMENT SYNDROME CAN BE SPONTANEOUS & UPPER ARM . and Protein Drugs . The central paradigm(. نموذج. ). of clinical pharmacology: The dose-concentration-effect relationship. Dose (mg/day) . pharmacokinetics. Concentration. (mg/l). Efficacy . Toxicity. . Alfonso Iorio, on behalf of the working group. DISCLOSURES. Financial conflicts of interests. McMaster University has received . funds for research. and . service agreements . from Bayer, . Baxalta. . Chelsea Marion, MD. 1,4. , Oluwaseun Odewole, MD, MPH. 2,4. , Sheila Goel, MD. 3,4. . 1. Dept. of Pediatrics, Morehouse School of Medicine, Atlanta, GA. . 2. Dept. of Family Medicine, Morehouse School of Medicine, Atlanta, GA. .