PPT-Lecture-7 Pharmacokinetics and Pharmacodynamics of Peptide

and Protein Drugs The central paradigm نموذج of clinical pharmacology The doseconcentrationeffect relationship Dose mgday pharmacokinetics Concentration mgl Efficacy Toxicity. & THERAPEUTICS . ESSENTIAL DRUG LIST . Alexandra Burke-Smith. 1. Drugs and the Autonomic Nervous System . Overview of the ANS . Sympathetic NS = “fight or flight”, Parasympathetic NS = “rest + digest”. Peptide Bond. Amino acid residues in peptides and proteins are linked together through a covalent bond called the peptide bond.. Two amino acid molecules can be covalently joined through a substituted amide linkage, termed a . -Hairpin Loops via Cold Ion Spectroscopy of Model Compounds. John T. Lawler, . Andrew . DeBlase. , Chris . Harrilal. , Scott A. . McLuckey. , Timothy S. . Zwier. 1. Why study . β. -turns?. 2. Diener. Jessica Tagerman, . PharmD. , . RPh. Pharmacokinetics & pharmacodynamics. Pharmacodynamics: What the drug does to the body. Pharmacokinetics: What the body does to the drug. pharmacodynamics. “What the drug does to the body”. CELL SURFACE RECEPTORS. Endocrine mediators. OUTLINE:. Sizes, origins and fate.. Occurance in blood: bound/unbound.. Listing of major examples.. Receptors and receptor binding.. Tour of a selected peptide hormone:. p.p.b.. -range mass accuracies and proteome-wide protein quantification. Yoona. Kim. University of California, San Diego. UCSD Mass Spectrometry Journal Club . 12/03/10. MaxQuant. of obstetric anesthesia . Dr SPS. 10/4/2015. 1. Dr. S. Parthasarathy MD., DA., DNB, . MD (. Acu. ), Dip. . Diab. . DCA, . Dip. Software statistics, . PhD (physiology) FICA . Mahatma Gandhi Medical College and Research Institute, . Pharmacokinetics and . Pharmacodynamics. of Peptide and Protein Drugs . The central paradigm of clinical pharmacology: The dose-concentration-effect relationship. Dose . pharmacokinetics. concentration. . peptide in . dog urine digest. Peptide Immunoaffinity enrichment. 7 min LC gradient. PRM analysis. Dilution. . series. fmol. /µl (. synthetic. EN). fmol. . (. synthetic. EN) . on . column. A. . Kasturee Chakraborty. 1. , . Chiranjit. Dutta. 2. , Abhijit Biswas. 2. , . Sanchita. Mukherjee. 1. , Paramita Gayen. 1. , Dhananjay Bhattacharyya. 3. *, . Rituparna. Sinha Roy. 1. *. 1. Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, . 1. Protein Chains are Polymers of Amino Acids. 2. Isoelectric Point. 3. (NH. 3. CH. 2. CO. 2. H). +. . + . H. 2. O. ⇌ . (NH. 3. CH. 2. CO. 2. ). . + . H. 3. O. +. . pKa. = 2.34. (. NH. 3. CH. 2. Sergey L. Sheetlin. ,. Yuri A. Mirokhin, Dmitrii V. Tchekhovskoi, Xiaoyu Yang, Stephen E. Stein. NIST Mass Spectrometry Data Center, Biomolecular Measurement Division,. National Institute of Standards and Technology. James W. Checco, Ph.D.. Assistant Professor of Chemistry. University of Nebraska-Lincoln. Peptidomics. analysis reveals changes in small urinary peptides in patients with interstitial cystitis/bladder pain syndrome (IC/BPS). Two or more amino acids covalently joined by . . . peptide bonds. .. Two . amino acid molecules can be covalently joined by . . peptide . bond to yield dipeptide.. This . linkage is formed by removal of the element of H.