THE HIERARCHY OF EVIDENCE Evidence based Medicine Sharon Strauss 4 th edition SYTEMATIC REVIEW AND META ANALYSIS Meta analysis A statistical technique used to combine the results of several studies addressing the same question into a single summary measure ID: 645571
Download Presentation The PPT/PDF document "Levels of evidence and Interpretation of..." is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
Slide1
Levels of evidence and Interpretation of a systematic reviewSlide2
THE HIERARCHY OF EVIDENCE
Evidence based Medicine: Sharon Strauss 4
th
editionSlide3
SYTEMATIC REVIEW AND META ANALYSIS
Meta analysis- A
statistical technique used to combine the results of several studies addressing the same question into a single summary measure
Systematic reviews do
not
have to
have a meta-analysisSlide4
THE COCHRANE COLLABORATION
International non-profit organisation that prepares, maintains, and disseminates systematic up-to-date reviews of health care interventionsSlide5
FOREST PLOT
Graphical representation of a meta analysis
“Forest of lines”
Originated in 80’s Modern forest plot - 1998Slide6
HOW TO READ A FOREST PLOT
Individual studiesSlide7
HOW TO READ A FOREST PLOT
Effect estimate for each study
Pooled estimateSlide8
HOW TO READ A FOREST PLOT
Confidence intervals of individual studies’ effect estimate
CI of pooled estimateSlide9
HOW TO READ A FOREST PLOT
Favours intervention
Favours control
Line of no effectSlide10
WHAT ELSE DOES THE FOREST PLOT SHOW?
Effect estimate for each study
Weight
Method/ Model used
HeterogeneitySlide11
FOREST PLOT FOR CONTINUOUS VARIABLES
Mean difference instead of relative riskSlide12
LEARNING POINTS IN THIS PODCAST
Levels
of evidence
Systematic review and meta analysis
Forest plot – Components
Interpretation