1591gastric mucosaassociatedlymphoid after cure pylori Lymphoma gastr - PDF document

1591gastric mucosa-associatedlymphoid after cure pylori Lymphoma gastric-mucosa-associated tissue(MALT) type has to investigated eradicating pylori low-grade associated with H to histology, B before treatment and during follow-up.at least two and became H a treatment On histology, complete (12%) oflymphoma. patients no after pylori Oftreated 4 were high-grade B-cellhistology resected stomach 1 high-grade PCR after cure pylori13 of medianof of MALT gastric completely of H pylori However, longer follow-up needed is 1995; Medical II, University Rudolph); of Rudolf Free C (N Lehn Institute Pathology,of Cologne Pathology,GermanyCorrespondence DepartmentD81377 gastric mucosa contains no tissue.who mucosa-associated tissue Helicobacter pylori reactionH heilmanii islinking H gastritis with of mucosa-associated lymphoid typeinfiltrationthe gastric mucosa but no evidence of destruction, between reactivedue gastritis early lymphoma difficult. 5,6 lymphoid infiltratesdue decrease quickly after the such thedifferential two small studies7,s suggestedearly havecarried establish whether pylori about low-grade investigated biopsy from obtained by gastroenterologists andprivate generalpractitioners, analysed one WheneverMALT diagnosed, asked enrol that patients criteria and their consent,in all endoscopic and so that be andclassified H sampleswere suspicious for molecular were from H pylorz culture. Endoscopictumorous lesions), Arbor asby Musshoff.IO included in the in or EIII stageswere physical examination, ultrasound was endoscopy, computed done.Where a lower endoscopy tumorous were found 1592number patients *1 had a and 1 was by be tPretreatment whenresected was examined of Table: Relation between outcometreatment, diagnostic procedures were exclude continuoustumour growth of wall

(submucosa,muscularis propria, in Biopsy were neutral mailed to for Thinthe some cases analysis recognise the and (CD20 CD45RO ; Hamburg,Germany). Binding visualised by an biotin "atypical used whenthe lymphoid led and proliferation to thediagnosis (grade eosin staining to grade the pylori. The of cure of pylori that completeregression tumour post-treatment biopsy the prediagnosed infiltrations, and completely lymphoid regression on documented.tumour defined of tunica lymphoid cells, focally lymphoepithelial suspicious transport medium Diego, California, USA) and central molecularlaboratory within 48 was extracted. the samples, framework region (primers Fr2a, Fr3a,VLJH) had be used monoclonal mostthe PCR subjected electrophoresis on gel of with (3-interferon was Only sampleswith included PCR for (RajiB-cell peripheral DNA also precautions taken PCR course ofin three doses 2’25 daily three doses.The first endoscopic examination was doneafter weeks end for H pylori examined 4 tumour completewas achieved, tumorous lesions were endoscopy,histology, genetic 6months.partial abnormal every weeks 26. change at the second post-treatment endoscopywere for surgical treatment or chemotherapy.The study enrolled and 15 women, with primary H pylori patients patient unknown allergy to amoxycillin omeprazoleamoxycillin were given 40 mg (in(both in three days. pylori the first withand amoxycillin.18outcome 33 low-grade in the table. histological criteria,regression 4 after of 6 showed response at endoscopies: surgical1 for chemotherapy courses No of MALT aftercure H pylori infection.andoutcome to In were lymph thus haveEll. The remaining was to have cm lymphoma,which as as high-grade After patients were median of 12.5 6-5-18-0). relapse low-grade gastric MALT lymphoma thedetected months

gastric MALT H pylori has monoclonal bands in patientsand in 5 on 1593first biopsy analysis from of achieved histological pylori In bandsno longer detectable complete histologicalregression In 3 patients B-be detected.MALT lymphoma about by of infection an in establishing the events We in our treated with regimenagainst H first evidence link H pyloriand et 7observed regression 5 H infection, group.8 Thefollow-up period in shorter in series (median clinical cell-biological causal relation. cells gastrectomysamples was H by of interleukin-2-receptor theownof H and MALT lymphoma from et that of lymphoma.histological, studieshave association between infection gastric MALT However, clinical and morphological that the from lymphomas.22 third of all have been lymphomas, they characteristics."," study, grade is by histology stomachs; inparagastric lymph these found no precursor stage in of high-gradewe postulate that high-grade so-called from MALT that remainsundetected a in who referred for treatment high-grade resection samples specimens.clonal evolution strongly the study of et al ’21 stronger and lymphoma in the of lymphomas whole Histology were complete started follow-up. the being cured follow-up to whether of MALTpylori been described 1 patient after pylori.25 An unexplained the detection biopsy samples of patients on endoscopy. might reflect but to taken et a 126 withearly of MALT lymphoma acourse antibiotic the that suggests H was notthe development primarybe the tissue in mucosaacquired pylori infection associated with early-stage tumour(Ell) complete in stages to high-grade malignancy of H pylori Further up is needed show regression MALT Lymphoma substantiallyto conception of the revising Seifert Kemperhof,HeidtA (Klinikum of Munich).Other patients Allmendinger Ba

stlein BaghdadiBerges J KrankenhausKemperhof, Diepholz),(Clemens-August-Krankenhaus, Speyer), J Habbig (Cologne), HeideggerKrankenhausH (Norden), Judmaier (Kreiskrankenhaus C Schlomann (Evangelisches (Klinikum Stein Marienhof, StoianJ Stumpf (Kreiskrankenhaus Thilo TrumpWambach Herten),J Weismuller (Koblenz), Acknowledgmentsthank Prof j Isaacson Dr and prepare thewas Society ReferencesWyatt JI, BJ. Immune the Campylobacter Gastroenterol 1988; (suppl 15942 Lymphoid follicles immuneCampylobacter 1269-71.Heilmann KL, Borchard F. to and ultrastructuralIsaacson PG.primary B-cell lymphoma. 1991; 338: 1175-76.of 6 and 1992; 7 Doglioni C, Regression of lymphoma tissue type eradication of pylori. 342:575-77.8 M, Healing lymphomas 1993; 568.Carbone K, Smithers DW, on Disease Cancer 1971; 31: 1860-61.Musshoff K. Stadieneinteilung der nicht-HodgkinLymphome. 11 Difference 102: 1575-82.12 Goodwin Warren Campylobacter ii: Sambrook Maniatis Spring 1989.Story CJ, Monoclonality 1990;Diss TC, H, Wotherspoon AC, PG, Pan grade lymphomas chain reaction independent of primer selection and lymphoma Brisco Morley B-cellwax chain reaction. J Pathol 880-90.chain basedin DNA: of &bgr;-interferon Res 1990; 993-97.Miehlke ofcure Helicobacter patients 1995; 19 lymphoma and N Med20 Hussell T, PG, Crabtree JE, The cellslow-grade B-cell lymphomas of lymphoid tissue to 1993; Parsonnet J, and gastric 22 R. influencing nodein of thePath Cogliatti U, gastricclinico-pathological study 145 patients. 1991; 101: 1159-70.Radaszkiewicz Dragosics B, P. Gastrointestinal the relevant102: 1628-38.Cammarota M, Vecchio FM, G,gastric lymphoma. M, Ertmann K. of MALT associated treatment. 1994; 343: 1098-99.27 M, Spencer 1994; 343: 1503.28 Harris Misiewicz 1994; 343: 1503.Weber Dimopoulos WC, gastric mucosa-associated w