PPT-A Randomized Trial of Protocol-Based Care for Early Septic Shock

Andrea Caballero MD January 15 2015 LSU Journal Club The ProCESS Investigators N Engl J Med 2014 37016831693 May 1 2014 Background T here are over 750000 cases of severe sepsis and septic shock per year in the US . AMWA Northern California Chapter . 04 Oct 2014. 10/4/2014. 1. Topics. Relevant definitions, background. Protocol audiences. Purposes of protocols. Protocol components. Per ICH . E6 . Additional (synopsis, glossary, appendices). Dr. Vida Hamilton. National Clinical Lead Sepsis. www.hse.ie/sepsis. Sepsis - 2. A dysregulated immune response to infection. Regulated. Innate & Adaptive. Cellular: Dendritic cells, T-cells, B-cells. Holger Thiele, . MD. o. n behalf of the CULPRIT-SHOCK Investigators. Disclosure Statement of Financial Interest. Grant/Research . Support. Consulting Fees/Honoraria. Major Stock Shareholder/Equity. Royalty Income. What is sepsis?. Sepsis is a complication of severe infection characterized by a systemic inflammatory response. . (. Gauer. , 2013). Sepsis can be present on admission, or it can occur during hospitalization. . Early recognition of Sepsis. Early Goal Directed Therapy . CASE. 6. 4yr . Samoan male. 24 . hr. . Fever, productive cough, SOB . and . delirium. Initial . Obs. HR 162, RR . 40, . sats. . 90% . on 15l, BP . Sri Venkateswara Institute of Medical College. Tirupathi. SHOCK. Shock is characterized by . systemic hypotension . due to either reduced cardiac output or reduced effective circulating blood volume. ILO’s. At the end of this presentation students will be able to. :. Describe the different . types of shock. .. Understand the . pathophysiology. of different types of shock.. Explain the . effect. Corticosteroids. There is significant uncertainty regarding the use of corticosteroids in patients with severe CAP requiring ICU admission. Several RCTs and meta-analyses have suggested benefit of treatment with corticosteroids, however existing evidence is not definitive and corticosteroids have a range of potentially adverse effects. Consensus Definitions for Sepsis . and Septic . Shock . Dr. . Kobra. . Tahermanesh. Fellowship in Minimally Invasive Gynecology. Associate . Professor of Iran University of Medical Sciences. Sepsis And Septic Shock. 415V Chest radiograph revealed large, round density in theright lung and consolidation areas in peripheral C A S E R E P O R T S 416V5th hour, the patient passed away. MethicillinStaphylococcus aure Hypovolemic and septic Shock Galal Ahmed Abushahba Cardiologist 09/02/2019 No disclosure Objectives:  Introduction.  Fluid responsiveness in shocked patient.  Heart lung interaction in mecha William W. O’Neill, MD. Henry Ford Health System. Medical Director. Center for Structural Heart Disease. Detroit, MI. Diffuse Multivessel. Disease. . Border Zone. Dysfunction. Central Zone. Dyskinesis. Recent Update. Dr. Apurba Kumar Borah. Head of the Department. Critical Care and Emergency Medicine. Narayana . Superspeciality. Hospital, . Amingaon,Guwahati. .. . Introduction. Experience the best eye care center in Pune. The best clinics for your eye health, include the prestigious Dr. Sonalika Eye Clinic. At Hadapsar, Amanora, Magarpatta, Mundhwa, Kharadi Rd, Viman Nagar, Wagholi, and Wadgaon Sheri