Developing Answerable Clinical Questions Searching the Medical Literature Qiana Amos MPH Overview Importance of the right Clinical Question Framing the Clinical Question PICO Format Use of an IT pl - PDF document

Developing Answerable Clinical Questions  Searching the Medical Literature Qiana Amos MPH  Overview Importance of the right Clinical Question Framing the Clinical Question PICO Format Use of an IT pl
Developing Answerable Clinical Questions  Searching the Medical Literature Qiana Amos MPH  Overview Importance of the right Clinical Question Framing the Clinical Question PICO Format Use of an IT pl

Developing Answerable Clinical Questions Searching the Medical Literature Qiana Amos MPH Overview Importance of the right Clinical Question Framing the Clinical Question PICO Format Use of an IT pl - Description


Albert Einstein To ensure your initiative is aligned with your strategy you need to be rigorous in defining the problem you are trying to solve and why those issues are important brPage 4br ASK Focus Question Critical Step Why Development of a clear ID: 35849 Download Pdf

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Developing Answerable Clinical Questions & Searching the Medical LiteratureQiana Amos, MPH OverviewImportance of the right Clinical QuestionFraming the Clinical QuestionPICO FormatUse of an IT platformInclusion/Exclusion criteriaLiterature searchArticle reviewUse of an IT platformBenefits The importance of asking the right question“If I were given one hour to save the planet, I would spend 59 minutes defining the problem and one minute resolving it.”Albert EinsteinTo ensure your initiative is aligned with your strategy you need to be rigorous in defining the problem you are trying to solve and why those issues are important. “ASK” Focus QuestionCritical Step, Why?Development of a clearly defined question is what creates the backdrop and ultimately sets the pace for the EBM processDeveloping an answerable clinical question is what forms the framework of which the evidence will be acquired What occurs without optimal energy and time?No longer effective or efficient (waste resources)Produce wrong or irrelevant outcomesDevelop recommendations that are not aligned with initiative’s strategies Framing The Clinical QuestionConverting the information needs into a clinical questionInvolves collaboration from all interested in the question and answer(s)Iterative processUltimately, a well defined and structured question facilitates efficient searching in the literature search and the likelihood of finding meaningful results PICO Format(Explicit, Focused Clinical Question) PICODefinition/DescriptionPatient, Population or ProblemIntervention, Prognostic Factor or ExposureComparison or Intervention (If appropriate)Outcome (Critical & Important)What type of question are you asking?Diagnosis, Etiology, Therapy, Prognosis, Prevention, HarmType of study you want to find?What would be the best study design/methodology Example: General Clinical Question��7 &#x/MCI; 8 ;&#x/MCI; 8 ;What medications should be given to patients with heart failure? Vague and general clinical question Difficult to construct PICO elements and conduct literature search from this questionNeed a more defined and focused questionFactors to consider to make this a specific clinical questionWhat is the population of interest? (e.g. adults, certain age groups, does the population of interest have additional comorbidities)What are the interventions of interest?Are we comparing these interventions with other treatment modalities?What outcomes are important to consider and/or look for in the literature? Example: Explicit, Specific Clinical Question Clinical Question: Should betablockers be used, in addition to standard treatment, for patients with LVSD?P Adults with LVSD on standard therapy for heart failure and without contraindications to betablockersBetablocker therapyPlaceboMortality due to cardiac causes; Allcause mortality; HospitalizationWhat type of question are you asking?Treatment Type of study you want to find?Metaanalyses, Randomized Controlled Trials Using an IT platform to define PICO 10 Using an IT platform to define PICO 11 Using an IT platform to define PICO Using an IT platform to define inclusion/exclusion criteriaFirst specify criteria in standardized PICO formStudy design, length of followup, languageRemaining inclusion/exclusion not in standardized PICO formAssessed during article review Conduct Literature SearchTranslate clinical question into defined search strategyUse terms related to the health condition of interest (populationterms related to the intervention(s), and terms specifying the type(s) of study designUse of both brand and “generic” namesUse of Boolean operatorsAll searches conducted using Medline (PubMed), CENTRAL (Cochrane Central Register of Controlled Trials)and the Cochrane Library of Systematic ReviewsOther databases/search engines used as needed Articles identified are loaded into IT platform 13 Example Search Study Inclusion/Exclusion Interface Export to Reference Manager® or Excel® Access to Full Text and Abstract Independently Rate as Relevant, Maybe Relevant, or Not RelevantAdministrator Capabilities to Collate and Adjudicate Responses Study Rating Interface ��Document Reasonsfor Rating 15 Study Selection/Rejection InterfaceAfter Adjudicating Ratings Document Reasons for Rejection 16 QUOROM Flow Diagram *Quality Of Reporting Of MetaanalysesLancet 1999 Automated Production of QUOROM* Flow DiagramMultiple Stages ofInclusion/Exclusion Overview of benefits of IT platform for literature reviewIncreased efficiencyAbility to track and document reasons for rejection, etcTrack those that still need to be reviewedAbility to have dual reviewDiscrepancies can be adjudicated using IT platform and marked as accepted or rejected More transparency in our decisionsCan include notes detailing why we rejected an article, important article information, etcNew articles are identified and added using a dynamic processArticles can be monitored over time and housed in one database for each clinical questionMore rigorous and allows us to better answer clinical questions

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