PPT-DNA Structure

By the early 1900s it was known that the chromosomes carry the genetic hereditary information Chromosomes are made up of DNA deoxyribose nucleic acid They now needed to know the structure of DNA. 3.3.1: Outline DNA nucleotide structure in terms of sugar (deoxyribose), base. and phosphate.. 3.3.2: State the names of the four bases in DNA.. 3.3.3: Outline how DNA nucleotides are linked together by covalent bonds. Stryer. Short course. Chapter 33. Nucleic Acid Structure. Nucleobase. Nucleoside. Nucleotide. Nucleic acid. Chromatin. Chromosome. Polymeric Structure. Polymer ideal for informational molecule. Ribose and deoxyribose. Lecture 1. An introduction to DNA Topology. DNA. DNA inside the . Nuclues. . The human cell contains 23 pairs of chromosomes. If we scale the cell nucleus to the size of Basketball then the DNA scales to 200km in length.. 2.6 Structure of DNA & RNA. Understandings:. The nucleic acids DNA & RNA are polymers of nucleotides.. DNA differs from RNA in the # of strands normally present, the base composition & type of pentose.. THINK ABOUT IT. The DNA molecule must somehow specify how to assemble proteins, which are needed to regulate the various functions of each cell.. What kind of structure could serve this purpose without varying from cell to cell?. shapes and patterns. 조연우. Contents. DNA. DNA origami. The application of DNA origami. DNA origami structure. “Normal DNA”. 이중나선 형태로 존재. Double Stranded, Double Helix. Adenine, Thymine, Guanine, Cytosine . Objectives. To explain how instructions in DNA lead to different cells and result in cells being able to perform certain tasks in an organism. Identify the building blocks and nitrogenous bases (A, T, G, C and U) of nucleic acids . DNA damage DNA gets damaged a lot ! DNA damage DNA gets damaged a lot! >200,000 events/human cell/day DNA damage Occurs 2 ways 1) spontaneously 2) mutagens : damage DNA Transposons Discovered by Barbara McClintock The formation of a highly organized DNA-protein complex, termed as chromatin, which is a nucleoprotein complex completes the packing.. Chromatin can be defined as highly condensed chromosomes at metaphase stage, and very diffuse structures in course of .  . Author: Michael Fenech. Affiliation: Genome Health Foundation, North Brighton, SA, 5048, Australia. Email: . mf.ghf@outlook.com. . Introduction. Life as we know it depends entirely on the capacity of cells to utilize energy and molecules in the environment for cellular function and reproduction. . histones. (50%). Five major . histones. ; H2A, H2B, H3, H4 and H1 highly basic (. Arg. and Lys >25%). Roger Kornberg in 1974; . Chromatin. is made up of repeating units called . nucleosomes. , each containing 200 . Mini whiteboards. Sweets for DNA model (see link to sheet on slide). Speakers. Practical ‘DNA your onions’: blender, knife, white tile, water bath (60. o. C), ice, thermometer, beakers, funnel, filter paper, syringe, boiling tube, glass rod, pipette, protease, washing up liquid, salt, 95% ice cold ethanol. Mitosis, Protein . Synthesis. Week 8. 9/29 . DNA Replication . 11.1. Obj. TSW demonstrate base pairing rules of DNA Replication by constructing a 2-D model of DNA with paper. . P. 68 NB. Replication Video. DNA Structure Simulation. Before we begin, let’s investigate the way DNA molecules are set up!. http://learn.genetics.utah.edu/content/molecules/builddna/. The Structure of DNA. What is DNA?. A bit about DNA….