PPT-Introduction to Epigenetics

BMICS 776 wwwbiostatwiscedubmi776 Spring 2019 Colin Dewey colindeweywiscedu These slides excluding thirdparty material are licensed under CC BYNC 40 by Anthony Gitter Mark Craven and Colin Dewey. Kevin Ferriter. Mariah Minder. From Yesterday…. Do you think your brain cell and your blood cell have the same DNA sequence?. Genetics. Every cell contains all of your DNA. Not every cell expresses all of your DNA. :. DNA . methylation. II. DNA . methylation. in plants (Ch9). Differences between plants and animals. Auxotroph . vs. . heterotroph. Sessile . vs. . mobile. Motionless and rigid . vs. . migrating and flexible cells. the process by which a trait/gene changes function; the gene has been . co-opted to do a new job. Gene Co-option. Inheritance of Acquired Characteristics. Epigenetics turns on/off genes. http://cnx.org/content/m26565/latest/graphics35.jpg. -What is epigenetics? -Epigenetics and us -Past, present, and future You Are What Your Mother Ate:What is Epigenetics?Daniel Lieber DNA is the Source of Heritable Information in the Cell organism Crea CpG. Island landscape. Héctor. Corrada Bravo. CMSC702 . Spring . 2013. (many slides courtesy of Rafael Irizarry). Genetics: the alphabet of life. Letters of DNA sequence carry the . information. How is this information read and parsed.. Daniel Messinger. , Ph.D.. Messinger. Hmmm…. ‘Mothers . who were . pregnant during a 1944 famine in the . Netherlands. were . more likely to have children—and grandchildren—prone to heart disease, diabetes, and obesity. . . Samudra. K. . Wijeratne. , Ph.D.. Dept. of Nutrition and Health Sciences, UNL. Processes in . Epigenetics. The . study of heritable changes in gene expression or cellular phenotype caused by mechanisms other than changes in the underlying DNA . How do we make this work?. Dr. Paul S. Anderson. NYANP. 2017. (c) PS Anderson - www.ConsultDrA.com - 2017. 1. Dr. Anderson - Disclosures. Ownership interest in:. • Advanced Medical Therapies Clinic Seattle, WA. Joo. ’ Kim. Louisiana State University. What is . Epigenetics. ?. “the study of mitotically and/or . meiotically. heritable changes in gene function that can not be explained . by changes . in DNA sequences” – (Riggs et al. 1996). http://www.knowabouthealth.com/wp-content/uploads/2010/06/mcdonalds_.jpg. http://emilyscarenhealth.wordpress.com/2011/10/04/attention-a-must-read-for-smokers/. Can “. nuture. ” change “nature” ?. nuture. ; how our environment talks to us, sometimes forever.. Nessa. Carey, The Epigenetics Revolution (2012). The epigenetics revolution is underway.. Nessa. Carey, The Epigenetics Revolution (2012). Epigenetics comprises (hereditary) changes in gene expression without altering the DNA sequence . Epigenetics is a biological subdiscipline that deals with questions of development, heredity, gene regulation and evolution . JABLONKA & LAMB: CHANGING CONCEPT OF EPIGENETICSment. We will then consider the practical importance of epigenetics in med-icine, agriculture, and ecology and, finally, look at the implications thatre ‘Epi’: On top of. . Definition:. The . study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself.. DNA. How many cell types are in the human body?.