PPT-DNA Replication, Repair & Recombination

Dr Kevin Ahern Structure Structure Structure One Strand of DNA Structure Introduction Structure Introduction DNA Structure DNA Forms SemiConservative Replication Discontinuous Replication. MUTAGENESIS. DNA DAMAGE. DNA REPAIR. RECOMBINATION. MUTAGENESIS. Mutations. Mutations are heritable permanent changes in the base sequence of DNA.. Point mutations may be . transitions. (e.g. GC→AT) or . 20.1 part 2. DNA replication. Earlier on in this unit we learned about mitosis or cell division.. In order for mitosis to occur and chromosomes to duplicate themselves, the DNA must copy itself exactly.. DNA Structure. The discovery of the structure. Francis Crick and James Watson. The deoxyribonucleic acid (DNA) molecule is the genetic blueprint for each cell and ultimately the blueprint that determines every characteristic of a living organism. The DNA molecule was discovered in 1951 by Francis Crick, James Watson, and Maurice Wilkins using X-ray diffraction. . Lecture . 26. th. Alexei Fedorov, 2014. Origin of Chess. http://www.expert-chess-strategies.com/who-invented-chess.html. http://www.ponderabout.com/archives/972/mind-boggling-exponential-growth.aspx. Chapter . 7.2. Processing of Genetic Material. What is DNA Replication. The process by which the DNA within a cell makes exact copies of itself. Balance of speed and accuracy. Used for growth, repair and embryonic development. . §. 4.3a DNA Replisome. . §. 4.3b DNA Damage. §. 4.3c DNA . Repair. IV. NUCLEAR BIOCHEMISTRY. §. 4.3a . DNA Replisome. Synopsis . 4.3a. DNA replication involves making . copies or “. replicas” of DNA. . Understanding DNA structure and replication is a prerequisite for understanding/using the principal tools of molecular biology . R. R. 0. R0. R0. 0. R0. R0. R. 0. R. RR. R0. 0. R0. 00. DNA: Structure & Replication. Directions: Front of card write term. On back write definition and draw picture . Chromosomes. Thread-like structure made of coiled DNA. Gene. Segment of DNA that codes for a specific trait. Nucleotide. In . their 1953 announcement of a double helix structure for DNA, Watson and Crick stated, . "It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.". CORE View metadata, citation and similar papers at core.ac.uk provided by University of Birmingham Research Portal Targeting DNA repair for anti-cancer therapy Thomas Helleday1,2,*, Cecilia Lundin, Be ABSTRACT Chemotherapy often targets dividing cells by causing DNA damage that leads to replication-dependent toxic lesions. Cells possess several overlapping DNA damage repair pathways that allow them . What is DNA?. DNA is a . Nucleic Acid in the nucleus. Polymer of . Nucleotides. Each nucleotide consists of. Deoxy. ribose (5-carbon sugar) . Phosphate group. a nitrogen-containing base. Four bases. Mitosis, Protein . Synthesis. Week 8. 9/29 . DNA Replication . 11.1. Obj. TSW demonstrate base pairing rules of DNA Replication by constructing a 2-D model of DNA with paper. . P. 68 NB. Replication Video. R. ecombination. 2. . Site-Specific . R. ecombination. 3. DNA . Transposition. Homologous Recombination at the Molecular Level. DNA BREAKS ARE COMMON AND INITIATE RECOMBINATION. Recombination repair DNA breaks by retrieving sequence information from undamaged DNA.