PPT-DNA Replication, Repair & Recombination

Dr Kevin Ahern Structure Structure Structure One Strand of DNA Structure Introduction Structure Introduction DNA Structure DNA Forms SemiConservative Replication Discontinuous Replication. MUTAGENESIS. DNA DAMAGE. DNA REPAIR. RECOMBINATION. MUTAGENESIS. Mutations. Mutations are heritable permanent changes in the base sequence of DNA.. Point mutations may be . transitions. (e.g. GC→AT) or . DNA damage and repair and their role in carcinogenesis. A DNA sequence can be changed by copying errors introduced by DNA polymerase during replication and by environmental agents such as chemical mutagens or radiation. by Dr. . Sawsan. . Saijd. . 1-Post replication events. 2- DNA repair and proofreading activity . While DNA replication errors are rare, they must be corrected by various DNA repair pathways.. . Post. Semiconservative vs. Conservative. DNA Polymerase. RNA Primase. Okazaki Fragments. Replication Errors. TeachWithFergy . Preview File. . Please . enjoy this preview of your Power Point. . Some slides appear blank because they have been removed.. Yadi. Zhou. 2013.12.05. RecA. protein. 38 . kiloDalton. Essential for the repair and maintenance of DNA. A . RecA. structural and functional homolog has been found in every . species. Homologous protein in .  . Author: Michael Fenech. Affiliation: Genome Health Foundation, North Brighton, SA, 5048, Australia. Email: . mf.ghf@outlook.com. . Introduction. Life as we know it depends entirely on the capacity of cells to utilize energy and molecules in the environment for cellular function and reproduction. . If we have an error one in a million this mean we will have 3000 errors during each replication cycle of the genome.. The genome of a typical mammalian cell . accumulates many . thousands of lesions during a 24-hour period.. . REPLICATION – GENERAL PRINCIPLES. START. Must be ready . Must know where to start . FINISH. Must all finish . Must ensure that each piece of DNA is replicated only once . Therefore must know where to finish . . . Donata. . Orioli. . . Risposta. . cellulare. al . danno. . . Ivana. . Scovassi. . RNA . . Giuseppe . Biamonti . GENE . Alternative Splicing differences are prevalent in cancer pathways. of intense freckling and high melanoma incidence, related to UV sensitivity. The syndrome actually results from defects in any of nine genes involved in repair of UV damage. C. EPAIRING DAMAGED OR CORE View metadata, citation and similar papers at core.ac.uk provided by University of Birmingham Research Portal Targeting DNA repair for anti-cancer therapy Thomas Helleday1,2,*, Cecilia Lundin, Be ABSTRACT Chemotherapy often targets dividing cells by causing DNA damage that leads to replication-dependent toxic lesions. Cells possess several overlapping DNA damage repair pathways that allow them REPLICATION ERRRORS AND THEIR REPAIR. The nature of mutations. Transitions. Transversions. Some replication errors escape proofreading. Mismatch repair removes errors that escape proofreading. Structure of . SOS Response Still Surprises Us. Bénédicte. Michel. DR . Nisreen. . tashkandy. King . abdulaziz. University . 2019. History . Miroslav . Radman. . discovered the DNA repair network in . Escherichia coli .