Lung Cancer Medical Aspects of Causation Aneuploidy Unlimited cell reproduction and failure of cell death Animal Studies Basic Toxicology New Data on Causation New Studies New Statistics Number of cases ID: 1006680
Download Presentation The PPT/PDF document "Lung Cancer Background and Developments ..." is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
1. Lung CancerBackground and Developments regarding the Role of Asbestos as a Cause of Lung Cancer
2. Lung Cancer: Medical Aspects of CausationAneuploidyUnlimited cell reproduction and failure of cell deathAnimal StudiesBasic Toxicology
3. New Data on CausationNew StudiesNew StatisticsNumber of casesYears since cessationNew Research on DNA and toxicology
4. Lung Cancer CausationSmoking as a CauseOther agentsRadon SilicaIndustrial Plant ExposureRefineryOther types of plants
5. Lung Cancer Causation: Asbestos as a CauseLung cancer has historically (early 20th Century) been associated with certain exposures to asbestos; Selikoff studies of Insulators;Usefulness of Historical data for lung cancer in 2014
6. Plaintiff Arguments on Lung Cancer Causation
7. Do not need Asbestosis to Attribute Lung Cancer to Asbestos
8. The Role of Animal StudiesDr. Brody and Photomicrographs
9. The Role of EpidemiologyCase Reports and Animal Studies can be includedAre some studies better than others? If so, which ones and Why?
10. At What Level of Asbestos Exposure can one attribute Lung Cancer to Asbestos?Reasoning and AuthorityIncreased Risk – Does Doubling of Risk Bear on Causation?
11. The Role of SynergyOld v. New StudiesLevels of Exposure
12. The Role of Governmental Regulatory Agency PapersWhat is the science? When can they Inform on Causation?
13. Defendants’ Arguments on Lung Cancer Causation
14. Asbestosis is needed to attribute Lung Cancer to AsbestosWeight of Science
15. What is Asbestosis?Pathology – Roggli StandardRadiology – CT and HRCT scansPFT/Other clinical dataConfounding dataUIPSmoking related Interstitial fibrosisCHF
16. If Asbestosis is not Found, one needs to find Significant Exposure to Asbestos25 f/cc-years of exposure or moreHammarHelsinkiOthers
17. Is Synergy Important?SelikoffMarkowitzOthers: Additive v. multiplicative
18. Use of Industrial Hygiene Data to Prove ExposureUsefulness of Retrospective StudiesWhat is a fiber/cc-year and how does this fit with causation?
19. Treatment of Low Dose Asbestos ExposureMedical v. Legal CauseDifferences between statesIncreased risk v. doubling of riskEffect of smoking on asbestos causationDoes fiber type matter?Ambient Air levels
20. Lung Cancer is not MesotheliomaChrysotile issueAmphibole: as little as .1 f/cc-year may cause mesotheliomaFor Lung Cancer, mixed exposure, 25 f/cc-year exposure or more? Helsinki
21. The Role of Cigarette WarningsPost 1962Post 1985Complete Defense in warnings cases?
22. Venue for Lung CancerMadison CountyOthers – California, New York, Pennsylvania, DelawareForum Non conveniens
23. Other Cancers2006 National Academy of Science DataLaryngeal and Ovarian Cancer - epidemiologyOther cancers