Cromwell WDL Bioinformatics workflows at any scale Jeff Gentry Data Sciences Platform The backdrop: data generation set to explode Story begins here Quarterly output (in TBases) of the Genomics Platform Plenty of workflow solutions to go
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Presentation Transcript
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Cromwell & WDL Bioinformatics workflows at any scale Jeff Gentry
Data Sciences Platform<br>
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The backdrop: data generation set to explode Story begins here Quarterly output (in TBases) of the Genomics Platform<br>
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Plenty of workflow solutions to go around Randall Munroe, XKCD
https://www.xkcd.com/927/ So of course we decided to create a new one.<br>
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Workflow language that humans can read/write
Methods developers and biomedical scientists at large
https://software.broadinstitute.org/wdl/
Execution engine that can
Run on any platform (on-prem and on Cloud)
Scale elastically based on workflow needs
https://github.com/broadinstitute/cromwell Meet WDL + Cromwell<br>
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Workflow Description Language https://software.broadinstitute.org/wdl/<br>
Cromwell execution engine Cromwell … HPC GA4GH Local Google Funnel Multiple backends for maximum flexibility Coming Soon: AWS, Azure, Alicloud<br>
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One-off Simple self-contained command
Appropriate for independent analysts Server mode API endpoints
More scalable
Some devops needs
Appropriate for production environments
Call-caching! (aka “ka-ching”) Two main ways to run Cromwell java -jar cromwell.jar \
run hello.wdl \
hello_inputs.json<br>
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Our production system: Genomes On The Cloud NFS Broad on-premises systems Zamboni workflow engine GS data buckets ad-hoc GCE cluster (created on the fly) PAPI Google Cloud Persistent Cromwell server<br>
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Our development setup: on-prem + on-cloud GS data buckets ad-hoc GCE cluster (created on the fly) PAPI Google Cloud Persistent Cromwell server REST API Direct
CLI<br>
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Example external implementation: Google wdl_runner GS data bucket ad-hoc GCE cluster (created on the fly) Creates GCE VM
Executes wdl_runner.py
Sets up Cromwell
Parses WDL workflow
Submits jobs to PAPI
Polls for completion
Copies metadata & outputs to output path
Destroys GCE VM https://cloud.google.com/genomics/v1alpha2/gatk Barebones implementation:<br>
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Example external implementation: wdlRunR Submit workflows to Cromwell
Use R values as inputs
Monitor jobs for completion
Retrieve data back into R
Outputs
Logs
Job metadata https://github.com/seandavi/wdlRunR Direct integration with R:<br>
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Dan Billings
Miguel Covarrubias
Thibault Jeandet
Chris Llanwarne
Ruchi Munshi
Khalid Shakir
Kate Voss The rest of the team<br>
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Thanks! My Email:
jgentry@broadinstitute.org
User Forum:
https://gatkforums.broadinstitute.org/wdl/categories/ask-the-wdl-team
More Information:
https://software.broadinstitute.org/wdl
https://www.github.com/broadinstitute/wdl
https://www.github.com/broadinstitute/cromwell<br>
