Lung Cancer Background and Developments regarding the Role of Asbestos as a Cause of Lung Cancer Lung Cancer: Medical Aspects of Causation Aneuploidy Unlimited cell reproduction and failure of cell death Animal Studies Basic Toxicology New
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Presentation Transcript
01
Lung Cancer Background and Developments regarding the Role of Asbestos as a Cause of Lung Cancer<br>
02
Lung Cancer: Medical Aspects of Causation Aneuploidy
Unlimited cell reproduction and failure of cell death
Animal Studies
Basic Toxicology<br>
03
New Data on Causation New Studies
New Statistics
Number of cases
Years since cessation
New Research on DNA and toxicology<br>
04
Lung Cancer Causation Smoking as a Cause
Other agents
Radon
Silica
Industrial Plant Exposure
Refinery
Other types of plants<br>
05
Lung Cancer Causation: Asbestos as a Cause Lung cancer has historically (early 20th Century) been associated with certain exposures to asbestos;
Selikoff studies of Insulators;
Usefulness of Historical data for lung cancer in 2014<br>
06
Plaintiff Arguments on Lung Cancer Causation<br>
07
Do not need Asbestosis to Attribute Lung Cancer to Asbestos<br>
08
The Role of Animal Studies Dr. Brody and Photomicrographs<br>
09
The Role of Epidemiology Case Reports and Animal Studies can be included
Are some studies better than others?
If so, which ones and Why?<br>
10
At What Level of Asbestos Exposure can one attribute Lung Cancer to Asbestos? Reasoning and Authority
Increased Risk – Does Doubling of Risk Bear on Causation?<br>
11
The Role of Synergy Old v. New Studies
Levels of Exposure<br>
12
The Role of Governmental Regulatory Agency Papers What is the science?
When can they Inform on Causation?<br>
13
Defendants’ Arguments on Lung Cancer Causation<br>
14
Asbestosis is needed to attribute Lung Cancer to Asbestos Weight of Science<br>
15
What is Asbestosis? Pathology – Roggli Standard
Radiology – CT and HRCT scans
PFT/Other clinical data
Confounding data
UIP
Smoking related Interstitial fibrosis
CHF<br>
16
If Asbestosis is not Found, one needs to find Significant Exposure to Asbestos 25 f/cc-years of exposure or more
Hammar
Helsinki
Others<br>
17
Is Synergy Important? Selikoff
Markowitz
Others: Additive v. multiplicative<br>
18
Use of Industrial Hygiene Data to Prove Exposure Usefulness of Retrospective Studies
What is a fiber/cc-year and how does this fit with causation?<br>
19
Treatment of Low Dose Asbestos Exposure Medical v. Legal Cause
Differences between states
Increased risk v. doubling of risk
Effect of smoking on asbestos causation
Does fiber type matter?
Ambient Air levels<br>
20
Lung Cancer is not Mesothelioma Chrysotile issue
Amphibole: as little as .1 f/cc-year may cause mesothelioma
For Lung Cancer, mixed exposure, 25 f/cc-year exposure or more?
Helsinki<br>
21
The Role of Cigarette Warnings Post 1962
Post 1985
Complete Defense in warnings cases?<br>
22
Venue for Lung Cancer Madison County
Others – California, New York, Pennsylvania, Delaware
Forum Non conveniens<br>
23
Other Cancers 2006 National Academy of Science Data
Laryngeal and Ovarian Cancer - epidemiology
Other cancers<br>
