Migraine Triptan therapy Triptans are recommended

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Migraine Triptan therapy Triptans are recommended
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Migraine Triptan therapy Triptans are recommended for the acute treatment of migraine for patients for whom over-the counter analgesics do not adequately relieve pain1-3. Triptans are agonists at 5-HT1B and 5-HT1D receptors, decreasing

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Migraine Triptan therapy Triptans are recommended for the acute treatment of migraine for patients for whom over-the counter analgesics do not adequately relieve pain1-3.
Triptans are agonists at 5-HT1B and 5-HT1D receptors, decreasing trigeminal neuron activity, and causing4:
Vasoconstriction of cerebral blood vessels
Inhibition of vasoactive peptide release by trigeminal neurons
Inhibition of nociception
The 5-HT1 receptor class contains five human subtypes 5-HT1A,B,D,E,F.
Some 5-HT1 receptor subtypes are localised to regions of the brain that are important in migraine physiology, including the meningeal blood vessels, as well as on trigeminal neurons4.
As a class, the triptans have largely replaced the ergot alkaloids, due to a better side effect profile5. 5-HT=5-hydroxytryptamine (serotonin)

1. Marmura et al. Headache 2015;55(1):3–20; 2. Worthington et al. Can J Neurol Sci 2013;40(5 Suppl 3):S1–S80; 3. Eigenbrodt et al. Nat Rev Neurol. 2021; 17(8): 501-514; 4. Tepper et al. Arch Neurol 2002;59(7):1084–1088; 5. Antonaci et al. Springerplus 2016;5:637;<br>