Snapdragons
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Snapdragons http:faculty.pnc.edupwilkinincompdominance.jpg http:www.dobermann-review.cominfogeneticsmendelsgeneticlawsGregor20Mendel.jpg HUH? Incomplete Dominance Neither allele is completely dominant over the other allele. A
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01
Snapdragons http://faculty.pnc.edu/pwilkin/incompdominance.jpg http://www.dobermann-review.com/info/genetics/mendels_genetic_laws/Gregor%20Mendel.jpg HUH?<br>
02
Incomplete Dominance Neither allele is completely dominant over the other allele.
A heterozygous phenotype
A mixture or blending of the two<br>
A heterozygous phenotype
A mixture or blending of the two<br>
03
Incomplete Dominance a third (new) phenotype appears in the heterozygous condition as a BLEND of the dominant and recessive phenotypes. Ex - Dominant Red (R) + Recessive White (r) = Hybrid Pink (Rr)<br>
04
Problem: Incomplete Dominance Show the cross between a pink and a white flower. - RR (0%) Rr (50%) rr (50%)
- ratio 1:1 - pink (50%); white (50%)
- ratio 1:1 GENOTYPES: PHENOTYPES:<br>
- ratio 1:1 - pink (50%); white (50%)
- ratio 1:1 GENOTYPES: PHENOTYPES:<br>
05
Four-o’ clock flowers Incomplete dominance
Neither Red (R)
or White (W) is dominant
When a homozygous red flower (RR)
Mix with a homozygous white flower (WW), the alleles blend in the hybrid (RW) to produce pink flowers<br>
Neither Red (R)
or White (W) is dominant
When a homozygous red flower (RR)
Mix with a homozygous white flower (WW), the alleles blend in the hybrid (RW) to produce pink flowers<br>
06
Andalusian Chickens Incomplete dominance
Neither Black (B) or
White (W) are dominant
The offspring of a black feathered chicken (BB) and a white feathered chicken (WW) are blue (BW) – BLUE HEN!!<br>
Neither Black (B) or
White (W) are dominant
The offspring of a black feathered chicken (BB) and a white feathered chicken (WW) are blue (BW) – BLUE HEN!!<br>
07
Codominance Two equally dominant alleles are expressed at the same time.
Heterozygous phenotype will have both phenotypes visible<br>
Heterozygous phenotype will have both phenotypes visible<br>
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Codominance in the heterozygous condition, both alleles are expressed equally with NO blending! Represented by using two DIFFERENT capital letters.
Example: Dominant Black (B) + Dominant White (W) = Speckled Black and White Phenotype (BW)
Sickle Cell Anemia - sick<br>
Example: Dominant Black (B) + Dominant White (W) = Speckled Black and White Phenotype (BW)
Sickle Cell Anemia - sick<br>
09
Shorthorn Cattle Co- dominance
Homozygous red (RR)
Homozygous white (WW)
The offspring of will have both red and white hairs (RW)
The offspring are heterozygous and called “roan”<br>
Homozygous red (RR)
Homozygous white (WW)
The offspring of will have both red and white hairs (RW)
The offspring are heterozygous and called “roan”<br>
10
http://search.vadlo.com/b/q?rel=2&keys=Dominance+Incomplete+Dominance+Codominance+PPT Roan Horse<br>
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Codominance Example: Speckled Chickens BB = black feathers
WW = white feathers
BW = black & white speckled feathers
Notice –
NO GRAY!
NO BLEND!
Each feather is
either black or white<br>
WW = white feathers
BW = black & white speckled feathers
Notice –
NO GRAY!
NO BLEND!
Each feather is
either black or white<br>
12
Codominance Example: Rhodedendron R = allele for red flowers
W = allele for white flowers
Cross a homozygous red flower with a homozygous white flower.<br>
W = allele for white flowers
Cross a homozygous red flower with a homozygous white flower.<br>
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Codominance Example: Roan cattle cattle can be red (RR – all red hairs) white (WW – all white hairs) roan (RW – red and white hairs together)<br>
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Codominance Example: Appaloosa horses Gray horses (GG) are codominant to white horses (WW). The heterozygous horse (GW) is an Appaloosa (a white horse with gray spots).
Cross a white horse with an appaloosa horse. W W G
W GW GW WW WW<br>
Cross a white horse with an appaloosa horse. W W G
W GW GW WW WW<br>
15
Sickle- Cell Anemia Co- dominance
Caused by an abnormal
Hemoglobin, the protein that
red blood cells use to carry
oxygen
Normal hemoglobin is (RR)
Sickle Cell shaped blood cells (SS)
People who are carriers (heterozygous) for the disease there is a mixture of both normal and sickle cell (RS)<br>
Caused by an abnormal
Hemoglobin, the protein that
red blood cells use to carry
oxygen
Normal hemoglobin is (RR)
Sickle Cell shaped blood cells (SS)
People who are carriers (heterozygous) for the disease there is a mixture of both normal and sickle cell (RS)<br>
16
Problem: Codominance Show the cross between an individual with sickle-cell anemia and another who is a carrier but not sick. N S S
S - NS (2) SS (2)
- ratio 1:1 - carrier (2); sick (2)
- ratio 1:1 GENOTYPES: PHENOTYPES:<br>
S - NS (2) SS (2)
- ratio 1:1 - carrier (2); sick (2)
- ratio 1:1 GENOTYPES: PHENOTYPES:<br>
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Let’s Stop and Think… Let’s say there are two alleles for the hair color trait- red and blue
What would be the resulting phenotype of a heterozygous pair if the alleles showed incomplete dominance?
A. Red
B. Blue
C. Purple
D. Red and Blue patches<br>
What would be the resulting phenotype of a heterozygous pair if the alleles showed incomplete dominance?
A. Red
B. Blue
C. Purple
D. Red and Blue patches<br>
18
Let’s Stop and Think… Let’s say there are two alleles for the hair color trait- red and blue
What would be the resulting phenotype of a heterozygous pair if the alleles showed codominance?
A. Red
B. Blue
C. Purple
D. Red and Blue patches<br>
What would be the resulting phenotype of a heterozygous pair if the alleles showed codominance?
A. Red
B. Blue
C. Purple
D. Red and Blue patches<br>
19
MULTIPLE ALLELISM When there is more than 2 alleles possible for a given gene.
Allows for a larger number of genetic and phenotypic possibilities.<br>
Allows for a larger number of genetic and phenotypic possibilities.<br>
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Multiple Alleles there are more than two alleles for a gene. Ex – blood type consists of two dominant and one recessive allele
options. Allele A
and B are
dominant over
Allele O (i)<br>
options. Allele A
and B are
dominant over
Allele O (i)<br>
21
Multiple Alleles: Lab Mouse Fur Colors Fur colors (determined by 4 alleles): black agouti yellow<br>
22
Multiple Alleles: Rabbit Fur Colors Fur colors (determined by 4 alleles): full, chinchilla, himalayan, albino<br>
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Blood Typing Blood types are A, B, O, and AB.
AB blood is a co-dominant trait.
Both the A blood and the B blood need to be dominant in order to make a combination of co-dominant blood types, which is AB.
IA IA IA iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii
IB IB
IB i i<br>
AB blood is a co-dominant trait.
Both the A blood and the B blood need to be dominant in order to make a combination of co-dominant blood types, which is AB.
IA IA IA iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii
IB IB
IB i i<br>
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BLOOD TYPES Antibody Anti – B Anti – A None Anti – A, Anti – B 4 ABO blood types 3 alleles of the I gene http://sydfish.files.wordpress.com/2008/02/bloodcells.jpg<br>
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Multiple Alleles: Blood Types (A, B, AB, O) Rules for Blood Types:
A and B are co-dominant (Both show)
AA or IAIA = type A
BB or IBIB = type B
AB or IAIB = type AB
A and B are dominant over O (Regular dom/rec)
AO or IAi = type A
BO or IBi = type B
OO or ii = type O<br>
A and B are co-dominant (Both show)
AA or IAIA = type A
BB or IBIB = type B
AB or IAIB = type AB
A and B are dominant over O (Regular dom/rec)
AO or IAi = type A
BO or IBi = type B
OO or ii = type O<br>
26
http://www.pennmedicine.org/health_info/images/19450.jpg<br>
27
http://duongchan.files.wordpress.com/2007/05/abobloodsystem.jpg<br>
28
http://image.wistatutor.com/content/feed/tvcs/blood_type5B15D.jpg<br>
29
http://www.biologycorner.com/anatomy/blood/images/bloodtypes.jpg<br>
30
Codominance & Multiple Alleles Human blood type is an example of both codominance and a trait with multiple alleles.
AB = universal acceptor
O = universal donor<br>
AB = universal acceptor
O = universal donor<br>
31
Rhesus Factor The Rhesus factor, also known as the Rh factor, gets its name from experiments conducted in 1937 by scientists Karl Landsteiner and Alexander S. Weiner.
Involved Rabbits which when injected with the Rhesus monkey’s red blood cells, produced an antigen present in the red blood cells of many humans http://content9.clipmarks.com/blog_cache/latimesblogs.latimes.com/img/E0C83714-56E5-4757-B9F1-604FCE5643C3<br>
Involved Rabbits which when injected with the Rhesus monkey’s red blood cells, produced an antigen present in the red blood cells of many humans http://content9.clipmarks.com/blog_cache/latimesblogs.latimes.com/img/E0C83714-56E5-4757-B9F1-604FCE5643C3<br>
32
Rhesus Factor The Rhesus factor is an antigen, or more specifically a protein, that exists on the surface of red blood cells.
If a person has either two (+) genes for Rh or one (+) and one (-) Rh gene, they will test Rh(+). A person will be negative only if they have 2 (-).<br>
If a person has either two (+) genes for Rh or one (+) and one (-) Rh gene, they will test Rh(+). A person will be negative only if they have 2 (-).<br>
33
It is very important in terms of babies: E.g. an Rh(-) mother may make antibody against an Rh(+) fetus if the baby gets a (+) gene from its father (Obstetricians screen pregnant women for this problem with blood tests).
The ABO and RH genes are only two of many blood antigens that are present on human red cells and must be matched up for successful blood transfusions. Relevance of Rh Factor & ABO Typing?<br>
The ABO and RH genes are only two of many blood antigens that are present on human red cells and must be matched up for successful blood transfusions. Relevance of Rh Factor & ABO Typing?<br>
34
Polygenic Traits traits produced by multiple genes
example: skin color<br>
example: skin color<br>
35
Sex-Linked Traits Gene is attached to the X chromosome only, not found on the Y chromosome at all. (women have XX, men have XY chromosomes). These disorders are more common in boys.
examples: red-green colorblindness<br>
examples: red-green colorblindness<br>
36
Sex-Linked Traits in males, there is no second X chromosome to “mask” a recessive gene. If they get an X with the disorder, they have it. Girls must inherit defective X’s from both parents.<br>
37
Sex-Linked Traits A: 29, B: 45, C: --, D: 26
Normal vision
A: 70, B: --, C: 5, D: --
Red-green color blind
A: 70, B: --, C: 5, D: 6
Red color blind
A: 70, B: --, C: 5, D: 2
Green color blind<br>
Normal vision
A: 70, B: --, C: 5, D: --
Red-green color blind
A: 70, B: --, C: 5, D: 6
Red color blind
A: 70, B: --, C: 5, D: 2
Green color blind<br>
38
Multifactorial Referring to control of the expression of a trait by several genes and environmental factors.
Many multifactorial traits show continuous distribution.<br>
Many multifactorial traits show continuous distribution.<br>
39
Multifactorial E.g. Human height usually between 120cm and 200cm, however these genes cannot be fully expressed without all the necessary nutrients from a healthy diet http://www.babble.com/CS/blogs/droolicious/menace-height.jpg<br>
40
PRACTICE QUESTIONS 1. In a certain case a woman’s blood type was tested to be AB. She married and her husbands blood type was type A. Their children have blood types A, AB, and B. What are the genotypes of the parents? What are the genotypic ratios of the children?<br>
41
2. In a certain breed of cow the gene for red fur, R, is codominant with that of white fur, W. What would be the phenotypic & genotypic ratios of the offspring if you breed a red cow and a white bull? What would they be if you breed a red & white cow with a red & white bull?<br>
42
3. A rooster with grey feathers is mated with a hen of the same phenotype. Among their offspring 15 chicks are grey, 6 are black and 8 are white.
a. What is the simplest explanation for the inheritance of these colors in chickens?
b. What offspring would you expect from the mating of a grey rooster and a black hen?<br>
a. What is the simplest explanation for the inheritance of these colors in chickens?
b. What offspring would you expect from the mating of a grey rooster and a black hen?<br>