PPT-Figure 3 Figure 3. Distribution of PrPSc (disease-associated form of prion protein)

Author : vivian | Published Date : 2024-02-09

Angers RC Seward TS Napier D Green M Hoover E Spraker T et al Chronic Wasting Disease Prions in Elk Antler Velvet Emerg Infect Dis 2009155696703 httpsdoiorg103201eid1505081458

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Figure 3 Figure 3. Distribution of PrPSc (disease-associated form of prion protein): Transcript

Angers RC Seward TS Napier D Green M Hoover E Spraker T et al Chronic Wasting Disease Prions in Elk Antler Velvet Emerg Infect Dis 2009155696703 httpsdoiorg103201eid1505081458. Creutzfeldt. -Jakob Disease. Human equivalent of mad cow . disease. Rare. , degenerative, fatal disease. Approximately 1 case per million per year. Typically people are diagnosed around age 60 . CJD belongs to a family of human and animal diseases known as the transmissible spongiform . Carlos Francisco Mendoza. Human Prion Diseases. Comparison of Prp. C. and . Prp. Sc. Evidence Supports the Prion Hypothesis. Genetic . Polymorphism. RPSA Polymorphisms have no direct influence on susceptibility to sporadic CJD. Prions. are infectious agents composed of protein in . misfolded. form.. initially thought to be viruses which replicated slowly within their hosts, but no nucleic acid found associated with infectious material.. Wadsworth J, Joiner S, Linehan JM, Balkema-Buschmann A, Spiropoulos J, Simmons MM, et al. Atypical Scrapie Prions from Sheep and Lack of Disease in Transgenic Mice Overexpressing Human Prion Protein. Emerg Infect Dis. 2013;19(11):1731-1739. https://doi.org/10.3201/eid1911.121341. Torres J, Andréoletti O, Lacroux C, Prieto I, Lorenzo P, Larska M, et al. Classical Bovine Spongiform Encephalopathy by Transmission of H-Type Prion in Homologous Prion Protein Context. Emerg Infect Dis. 2011;17(9):1636-1644. https://doi.org/10.3201/eid1709.101403. Babelhadj B, Di Bari M, Pirisinu L, Chiappini B, Gaouar S, Riccardi G, et al. Prion Disease in Dromedary Camels, Algeria. Emerg Infect Dis. 2018;24(6):1029-1036. https://doi.org/10.3201/eid2406.172007. Diack AB, Ritchie D, Peden AH, Brown D, Boyle A, Morabito L, et al. Variably Protease-Sensitive Prionopathy, a Unique Prion Variant with Inefficient Transmission Properties. Emerg Infect Dis. 2014;20(12):1969-1979. https://doi.org/10.3201/eid2012.140214. Seuberlich T, Gsponer M, Drögemüller C, Polak MP, McCutcheon S, Heim D, et al. Novel Prion Protein in BSE-affected Cattle, Switzerland. Emerg Infect Dis. 2012;18(1):158-159. https://doi.org/10.3201/eid1801.111225. Angers RC, Seward TS, Napier D, Green M, Hoover E, Spraker T, et al. Chronic Wasting Disease Prions in Elk Antler Velvet. Emerg Infect Dis. 2009;15(5):696-703. https://doi.org/10.3201/eid1505.081458. Baron T, Bencsik A, Biacabe A, Morignat E, Bessen RA. Phenotypic Similarity of Transmissible Mink Encephalopathy in Cattle and L-type Bovine Spongiform Encephalopathy in a Mouse Model. Emerg Infect Dis. 2007;13(12):1887-1894. https://doi.org/10.3201/eid1312.070635. Honkavuori KS, Shivaprasad H, Williams BL, Quan P, Hornig M, Street C, et al. Novel Borna Virus in Psittacine Birds with Proventricular Dilatation Disease. Emerg Infect Dis. 2008;14(12):1883-1886. https://doi.org/10.3201/eid1412.080984. Weissenböck H, Bakonyi T, Sekulin K, Ehrensperger F, Doneley RJ, Dürrwald R, et al. Avian Bornaviruses in Psittacine Birds from Europe and Australia with Proventricular Dilatation Disease. Emerg Infect Dis. 2009;15(9):1453-1459. https://doi.org/10.3201/eid1509.090353. 2. CNS Infection - Meninges. CNS infections: most are due to sepsis. Pathogenesis:. Hematogenous spread (most common) . Traumatic implantation . Local extension from nearby infection . Ascent of peripheral nerve. Torres J, Andréoletti O, Lacroux C, Prieto I, Lorenzo P, Larska M, et al. Classical Bovine Spongiform Encephalopathy by Transmission of H-Type Prion in Homologous Prion Protein Context. Emerg Infect Dis. 2011;17(9):1636-1644. https://doi.org/10.3201/eid1709.101403.

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Prions Genetic Polymorphism & Susceptibility

PRIONS What are PRIONS?

PPT-Figure 3 Figure 3. Distribution of PrPSc (disease-associated form of prion protein)

Presentation Embed Code

Download Presentation

Figure 3 Figure 3. Distribution of PrPSc (disease-associated form of prion protein): Transcript

Prions Genetic Polymorphism & Susceptibility

PRIONS What are PRIONS?

Figure 1 Figure 1. . Detection of disease-related prion protein (PrPSc) in brains of

Figure 2 Figure 2. Western blot analyses of brain protease-resistant prion protein

Figure 1 Figure 1. Hematoxylin and eosin staining (A, B), immunohistochemistry (C–O),

Figure 4 Figure 4. Neuropathology in transgenic mice following inoculation with brain

Figure Figure. Molecular typing of the pathologic prion protein from 2 cows with

Figure 4 Figure 4. PrPSc (disease-associated form of prion protein)–specific

Figure 4 Figure 4. Brain lesion profiles (left panels) and disease-associated

Figure 2 Figure 2. A) Similarity plot between Borna disease virus (BDV) prototype

Figure 1 Figure 1. Avian bornavirus protein demonstrated by immunohistochemical

1 CNS Infection Meninges and Prions

Figure 7 Figure 7. Abnormal isoform of host-encoded prion protein (PrPSc) deposition

PPT-Figure 3 Figure 3.&nbsp;Distribution of PrPSc (disease-associated form of prion protein)

Presentation Embed Code

Download Presentation

Figure 3 Figure 3.&nbsp;Distribution of PrPSc (disease-associated form of prion protein): Transcript

Prions Genetic Polymorphism & Susceptibility

PRIONS What are PRIONS?

Figure 1 Figure 1. . Detection of disease-related prion protein (PrPSc) in brains of

Figure 2 Figure 2.&nbsp;Western blot analyses of brain protease-resistant prion protein

Figure 1 Figure 1. Hematoxylin and eosin staining (A, B), immunohistochemistry (C–O),

Figure 4 Figure 4. Neuropathology in transgenic mice following inoculation with brain

Figure Figure.&nbsp;Molecular typing of the pathologic prion protein from 2 cows with

Figure 4 Figure 4.&nbsp;PrPSc (disease-associated form of prion protein)–specific

Figure 4 Figure 4.&nbsp;Brain lesion profiles (left panels) and disease-associated

Figure 2 Figure 2.&nbsp;A) Similarity plot between Borna disease virus (BDV) prototype

Figure 1 Figure 1.&nbsp;Avian bornavirus protein demonstrated by immunohistochemical

1 CNS Infection Meninges and Prions

Figure 7 Figure 7.&nbsp;Abnormal isoform of host-encoded prion protein (PrPSc) deposition

PPT-Figure 3 Figure 3. Distribution of PrPSc (disease-associated form of prion protein)

Figure 3 Figure 3. Distribution of PrPSc (disease-associated form of prion protein): Transcript

Figure 2 Figure 2. Western blot analyses of brain protease-resistant prion protein

Figure Figure. Molecular typing of the pathologic prion protein from 2 cows with

Figure 4 Figure 4. PrPSc (disease-associated form of prion protein)–specific

Figure 4 Figure 4. Brain lesion profiles (left panels) and disease-associated

Figure 2 Figure 2. A) Similarity plot between Borna disease virus (BDV) prototype

Figure 1 Figure 1. Avian bornavirus protein demonstrated by immunohistochemical

Figure 7 Figure 7. Abnormal isoform of host-encoded prion protein (PrPSc) deposition