PPT-PRIONS What are PRIONS?

Prions are infectious agents composed of protein in misfolded form initially thought to be viruses which replicated slowly within their hosts but no nucleic acid found associated with infectious material. Web: . pollev.com/. ucibio. Text: . To: 37607. . Type in: 169964 <your question>. The importance of structure. “Chaperones” & protein folding. Misfolded. proteins are very, very bad!. Bacterial Infections. Colonization by harmful bacteria. Using the body as resources to grow and reproduce. Battled by the immune system. Different numbers of bacteria needed to overwhelm the immune system and cause infection. Inherited and transmissible by ingestion, transplant, and surgical instruments. Spongiform encephalopathies: Sheep scrapie, Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia, mad cow disease. Prusiner. MD. 1942-present . KUMC Neurology Morning Report. Richard J. Barohn, MD. May 8, 2017. Stanley B. . Prusiner. Biography. YEAR. ACHIEVEMENT. 1942. Born in . Des Monies IA. 1896 Grandfather emigrated from Moscow to Sioux City, IA. HIGHLIGHTSNATURE REVIEWS MOLECULAR CELLBIOLOGYVOLUME 2 JULY 2001 In the Golgi,mannose-6-phosphatereceptors (M6PRs) grab newly synthe-sized lysosomal hydrolases by theirsugars to whizz them to their fi Carlos Francisco Mendoza. Human Prion Diseases. Comparison of Prp. C. and . Prp. Sc. Evidence Supports the Prion Hypothesis. Genetic . Polymorphism. RPSA Polymorphisms have no direct influence on susceptibility to sporadic CJD. NREC March 1. st. , 2018. Transmissible Spongiform Encephalopathy. Cattle – BSE. Sheep – Scrapie. CWD – some . Cervids. Others in Mink, Cats, etc.. History of CWD. • First identified in elk of wild origin in the mid 1960’s at Colorado State University. Atif. . Chohan. & Alex . Brown. What is CJD?. Degenerative brain disorder. Uncommon, usually fatal. Appears in older people, short duration. First described in 1920. Hans Gerhard . Creutzfeld. /. Sakudo mice (Angers et al. , 2006). " is # nding indicates that muscle is a potential source of infec - tion, suggesting that the meat of deer must be treated with caution. At this time it remains For More Information Contact: • NORTH DAKOTA GAME AND FISH DEPARTMENT 100 N Bismarck Expressway Bismarck, ND 58501 701-328-6300 gf.nd.gov – ndgf@nd.gov • BOARD OF ANIMAL HEALTH  Dept. of Biology, 2. nd. year, 2020. Mustansiriyah. University. References:. Virology: principles and applications, John Carter and Venetia Saunders, 2013.. Principles of Molecular Virology, Alan, J. . Discovery of Viruses. Beijerinck. (1897) coined the Latin name “virus” meaning poison. He studied filtered plant juices & found they caused healthy plants to become sick. Introduction. Viruses, . 2. CNS Infection - Meninges. CNS infections: most are due to sepsis. Pathogenesis:. Hematogenous spread (most common) . Traumatic implantation . Local extension from nearby infection . Ascent of peripheral nerve. Assist. Prof. Dr. Hussein Al . Naji. Bovine spongiform encephalopathy (BSE) is a progressive, fatal, infectious neurologic disease of cattle that resembles scrapie of sheep and goats. It was first diagnosed in the UK in 1986. Approximately 200,000 cases of BSE have been diagnosed in cattle, almost all of which were in the UK. In 1992, at the peak of the UK outbreak, 37,280 cases were reported in a single year..