PPT-Bovine Spongiform Encephalopathy

Assist Prof Dr Hussein Al Naji Bovine spongiform encephalopathy BSE is a progressive fatal infectious neurologic disease of cattle that resembles scrapie of sheep and goats It was first diagnosed in the UK in 1986 Approximately 200000 cases of BSE have been diagnosed in cattle almost all of which were in the UK In 1992 at the peak of the UK outbreak 37280 cases were reported in a single year. Christina Hill . Department of Biological Sciences, York College of Pennsylvania. Project Summary. Bovine Spongiform Encephalopathy (BSE) and Natural Scrapie are prion diseases that result from the mis-folding of proteins in the brain. One mis-folded protein can cause other proteins to mis-fold creating florid plaques that can affect motor function and decrease lifespan. Prion diseases can be transferred to animal species that are not naturally susceptible to these diseases through gene transfer. Research shows that brain plaque isolates from animals infected with prion diseases can be collected and inserted into the brains of transgenic mice. In the proposed experiment, 10 (OvTgPrP4) transgenic mice will be injected with normal saline, 10 with BSE isolates and 10 with Natural Scrapie isolates. Inoculated transgenic mice are observed for changes in motor function each week for course of their lifespan. After expiration, the mice can be dissected and their brain removed. The removed brains would be paraffin-embedded for microtome sectioning. These sections will be stained using Immunohistochemistry to look for the presence of florid plaques associated with the respective disease. Isolates from each mouse brain will also be tested for infection using a Sandwich ELISA test. Infection in all mice inoculated with the respective diseases should be found, as well as a decrease in motor dysfunction and lifespan. Effective transmission of prion diseases to species without natural susceptibility can allow for more effective medical models to be developed and increased knowledge of these diseases.. By: Michelle Russell. Case Study Presentation. NUR 4216L. 12-4-12. 1. Objectives. Understand the . pathophysiology. of hepatic encephalopathy. Recogonize. the signs/ symptoms. Understand relevance to clinical setting and patient scenarios. Other Brain Diseases. James S. Kennedy, MD, CCS, CDIP. President and Chief Medical Officer. CDIMD – Physician Champions. Smyrna, Tennessee. jkennedy@cdimd.com. – (615) 479-7021. Disclosures. This presentation is designed to provide accurate and authoritative information in regard to the subject matter covered. The information includes both reporting and interpretation of materials in various publications, as well as interpretation of policies of various organizations. This information is subject to individual interpretation and to changes over time. . Neonatal . Conference:. Decision Making for Optimal Care and Outcome. April 9, 2015. Cooling… and Beyond!. Objectives. Define :. hypoxia, anoxia, . perinatal. asphyxia, ischemia, and HIE. Discuss . 2017; 16 (1): 140-148 female sex, comorbid diabetes mellitus (DM), non-alcoholic causes of por- ascites as the indication for TIPS,hypoalbuminaemia, high serum creatinine, hepatofugal high Child-Pug Professor of Medicine. Division of Gastroenterology and Hepatology. University . of Washington. Hepatic Encephalopathy. Last . Updated: . August 21, 2013. Disclosure Slide. Dr. Landis receives research support from the following:. Rand . Al-shayeb. Selena . Abboud. Definitions. Hypoxia or Anoxia: . A partial (Hypoxia) or complete (Anoxia) lack of oxygen in the brain or blood.. Hypoxemia: . D. ecreased arterial concentration of Oxygen. . . Distribution of animal rabies in the United States, 1999. The percentages relate to the total number of cases of animal rabies. . Cats are not vaccinated in the US. . 1.1 4.3 0.9 0.6-----2008 . Curtis Barry, MD. March 31, 2017. HEPATIC ENCEPHALOPATHY. Hepatic Encephalopathy. Definitions. Hepatic Encephalopathy. Potentially reversible . neuropsychiatic. abnormalities seen in patients with liver dysfunction or . Journal of Current Med ical And Applied Sciences, 2015, July, 7(2), 133 - 138 . IJCMAAS,E - ISSN:2321 - 9335,P - ISSN:2321 - 9327. Page | 1 33 Prec ipitating Factors of Metabolic Ence 99-100. Brief Communication A Case of Bovine Spongiform Encephalopathy in Denmark Bovine spongiform encephalopathy (BSE), a transmissible spongiform encephalopathy in cattle, was first described in 99 Neurology AsiaMarch 2015 myelin. Coexistence of polyneuropathy may cause some patients with Wernicke’s encephalopathy to experience limb ataxia and dysarthria. It is estimated that 19% of pati Brown P, Brandel J, Sato T, Nakamura Y, MacKenzie J, Will RG, et al. Iatrogenic Creutzfeldt-Jakob Disease, Final Assessment. Emerg Infect Dis. 2012;18(6):901-907. https://doi.org/10.3201/eid1806.120116. Piccardo P, Cervenakova L, Vasilyeva I, Yakovleva O, Bacik I, Cervenak J, et al. Candidate Cell Substrates, Vaccine Production, and Transmissible Spongiform Encephalopathies. Emerg Infect Dis. 2011;17(12):2262-2269. https://doi.org/10.3201/eid1712.110607.