PPT-Prediction of anti-diabetic activity of flavonoids targeting α-glucosidase

Marisa Freitas Adelaide Sousa Daniela Ribeiro Eduarda Fernandes Introduction Diabetes mellitus is a pandemic disease and is one of the main threats to human health Figure 1 Global projection for diabetes epidemic 20112030 . Alpha-. G. lucosidase. by . Bioflavanoids. : . In Vitro. and . In Vivo. Studies . Anneke Tucker. Dr. Meltem Musa. Dr. Balz Frei. HHMI Symposium Presentation . September 23, 2010. The Problem. TYPE II DIABETES MELLITUS . Ficus lutea . (. Moraceae. ) in the management of Type II diabetes in a mouse obesity model . Oyinlola. O. . Olaokun. Introduction. Metabolic . disorder characterized by chronic . hyperglycemia. Defect in insulin secretion, impaired . effect of Hesperidin on Alpha glucosidase activity and small intestinal morphology. . in diabetic rats. 1. Phichittra. Od-. ek. Department of Physiology. Faculty of Medical Science. Naresuan. University. Suzanne Hendrich, PhD. University Professor, Iowa State University. Learning outcomes. Identify key flavonoid structures & classes. Identify key food sources of major dietary flavonoids. Describe structure/activity relationships influencing bioavailability of flavonoids. Secondary Metabolites. 1) Primary metabolites are essential. for life process. . (Growth of. the cells. ). These. are non-essential.. 2)These are. identified universally, throughout the source.. These are seldom, like in some portions of the source, like steam, bark, etc.. glycosides improved its antioxidant ecacy Zhang etal al 15 found that hydrolysis of Apocynum venetum avonoid glycosides improved the extraction of avonoids from its leaves and thus its antidepressant 2006FederationofEuropeanBiochemicalSocietiesPublishedbyElsevierBVAllrightsreservedGlycosidehydrolasefamily31Substratespecicity-GlucosidaseGlycosidehydrolasefamily27Site-directedmutagenesis1Introductio quinazolinone. derived Schiff base and its Cu(II) complex. Šárka. . Pospíšilová. . 1*. , Jana Hricovíniová. 2. ,. . Alois. . Čížek. 3. ,. Zuzana . Hricovíniová. 4. , . Josef Jampílek. Department : Dairy Technology. Course Title : Food Technology I. Course No. : DTT -322. Course Teacher: . Bipin. Kumar Singh. Phytochemical. Consumption of fruits and vegetables has since long been associated with lesser incidences of certain . evaluation guided by GC-MS analysis of ethyl acetate leaves extract of . Acacia . auriculiformis.  . Benth. .. Naresh. Kumar . Rangra. 1,. *, . Subir. . Samanta. , . and . Kishanta. Kumar . Pradhan. 44 Dipeptide synthesis and evaluation of anti-diabetic activity of 4-hydroxyisoleucine from fenugreek seedsSridevi P*, Lakshmi GA, Vunutha K, Akshitha K, Mahesh K & BhagavanRaju MDepartment of Pharmac TheglycogenstoragediseasesTransferasepo~oppo(a)phosphorylaselimitdextrinamylo-1,6-glucosidase�0(b)Fig2aOuterchainstructureoftheglycogenmoleculeafterphosphorylaseaction.Fig2bActionofdebranchings Dr. Sara . Assadiasl. MD.PhD. . of immunology. Assistant professor. Molecular immunology research center. Tehran university of medical sciences. Immunosuppression. T cell inhibition. B cell inhibition. Mucuna pruriens . in Experimental Model of Swiss. Albino Mice. Anjula Sachan, Sarvesh Kumar, Hemant Singh, Pratap Shankar, Dheeraj Kumar, Amod Kumar Sachan, Rakesh Kumar Dixit. The usage of benzodiazepines, the major class of anxiolytic drugs is invariably accompanied by many side-effects like sedation and muscle relaxation leading to incoordination of movements. Search for novel anxiolytic agents have identified flavonoids as potential compounds devoid of these adverse effects. Mucuna pruriens commonly known as cowhage plant has been claimed to possess various beneficial effects like anti-parkinsonian, anti-tumor, neuroprotective, antioxidant, anti-diabetic and antimicrobial activities. Previous studies have reported that Mucuna pruriens contains LDOPA and 5-hydroxy tryptophan (5-HT) as a major constituent with higher concentration in seeds. .