PPT-Mechanisms and Extent of Thrombin Generation in Trauma-Induced

Coagulopathy Thomas Orfeo PhD University of Vermont Fig 1 This figure represents our current understanding of traumainduced coagulopathy Gonzalez E et al Scandinavian Journal of Surgery 201410389103. & HUMILIATION. . . Hélène Lewis MSc (. Clin. . Psych). The most recent neuroscience findings on trauma in this presentation is based on Professor Bessel van der . Kolk’s. from Harvard Medical School, Trauma center in Boston. . Thrombin Substrate. PEPTIDE. SEQUENCE. CHARGE. Substrate. Acetyl-N-D. -. D. -. -{. Nle. }-TPR. +. /GSAGAGAG- . diamino. -ethyl-. BFL. -1. Cleaved Fragments. N-terminal. Acetyl-N-D. -. D. -. -{. Nle. }-TPR. Soheil Altafi MD. 1/27/15. DILI- Table of Contents. Introduction. Epidemiology. Liver - Drug Metabolism. Factors influencing Drug Metabolism. Mechanisms of Drug-induced Hepatotoxicity. Clinical Presentation. Project 2: The Role of Factor XI. . in TIC. Lead investigator: . Saulius. . Butenas. (University of Vermont). Co-Investigator: James H Morrissey (University of Illinois at Urbana-Champaign). Philadelphia, September 10, 2014. Sexual . Dysfunction. Flavio . Guzman. , MD. Overview. Normal sexual response: 4 phases. Baldwin, D., & . Mayers. , A. (2003). Sexual side-effects of antidepressant and antipsychotic drugs. . . Soheil Altafi MD. 1/27/15. DILI- Table of Contents. Introduction. Epidemiology. Liver - Drug Metabolism. Factors influencing Drug Metabolism. Mechanisms of Drug-induced Hepatotoxicity. Clinical Presentation. Roger Baker. Professor of Clinical Psychology. Bournemouth University. November . 2013. What is a trauma?. What is a trauma?. Personal accidents e.g. car crash. Large scale accidents e.g. King’s Cross station fire. Trans-Agency Consortium for the Analysis and Characterization of Trauma Induced Coagulopathy . Philadelphia Sept 10 . 2014. COAGULOPATHY. Consumptive. Dilutional. Acidosis. Hypothermia. Inflammation/Vascular Cell Mediated. Institute for Nuclear Problems, Belarus State University, Belarus. The XII-. th. International School-Seminar.  . The Actual Problems of . Microworld. Physics . Gomel, Belarus, July 22 - August 2, 2013. www.ecat.nl Activation of TAFI by Thrombin Symbol Name HK High molecular weight Kininogen FXII Factor XII FXIIa Activated Factor XII FXI Factor XI FXIa Activated Factor XI FIX Factor IX FIXa Activat June 5, 2015. What is TEG?. TEG is a functional assay which measures the blood’s ability to form a clot. Measures clot formation via the tensile strength of fibrin-polymer-platelet complex. First developed in Germany in 1948. gestation. Ddimer and VIII significantly increased from prepregnancy levels by 59 days gestation. Estradiol significantly increased byDay gestation with a nonsignificant increase of 67% by Day 24 ges in vitro . sequesters . Y. pestis . Thrombin added at t=0. 30 second exposure/frame. Plays . at 7 frames/s. Movies S4.2-S4.3:. The T3SS facilitates escape of . Y. pestis. from platelet . thrombi . in vitro. DR. HAMAD ALQAHTANI. ASSISTANT PROFESSOR & CONSULTANT HEPATOBILIARY SURGEON. . Mechanisms and Patterns of Injury. PENETRATING. . BLUNT. Classified . into. :. 1. Stab wound. 2. Gunshot wound.